Retracted: Microvascular resistance reserve in the presence of functionally significant epicardial stenosis and changes after revascularization
Abstract In the presence of functionally significant epicardial lesions, microvascular resistance reserve (MRR) calculation needs incorporation of collateral flow. Coronary fractional flow reserve (FFRcor) requiring coronary wedge pressure (Pw), which is an essential part of the true MRR calculation...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-03-01
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| Series: | Physiological Reports |
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| Online Access: | https://doi.org/10.14814/phy2.15627 |
| _version_ | 1827589960421605376 |
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| author | Yoshihiro Hanyu Masahiro Hoshino Eisuke Usui Tomoyo Sugiyama Yoshihisa Kanaji Masahiro Hada Tatsuhiro Nagamine Kai Nogami Hiroki Ueno Kodai Sayama Kazuki Matsuda Tatsuya Sakamoto Taishi Yonetsu Tetsuo Sasano Tsunekazu Kakuta |
| author_facet | Yoshihiro Hanyu Masahiro Hoshino Eisuke Usui Tomoyo Sugiyama Yoshihisa Kanaji Masahiro Hada Tatsuhiro Nagamine Kai Nogami Hiroki Ueno Kodai Sayama Kazuki Matsuda Tatsuya Sakamoto Taishi Yonetsu Tetsuo Sasano Tsunekazu Kakuta |
| author_sort | Yoshihiro Hanyu |
| collection | DOAJ |
| description | Abstract In the presence of functionally significant epicardial lesions, microvascular resistance reserve (MRR) calculation needs incorporation of collateral flow. Coronary fractional flow reserve (FFRcor) requiring coronary wedge pressure (Pw), which is an essential part of the true MRR calculation, is reportedly estimated by myocardial FFR (FFRmyo) not requiring Pw measurement. We sought to find an equation to calculate MRR without the need for Pw. Furthermore, we assessed changes in MRR after percutaneous coronary intervention (PCI). An equation to estimate FFRcor was developed from a cohort of 230 patients who underwent physiological measurements and PCI. Corrected MRR was calculated using this equation and compared with true MRR in 115 patients of the different set of the validation cohort. True MRR was calculated using FFRcor. FFRcor and FFRmyo showed a strong linear relationship (r2 = 0.86) and an equation was FFRcor = 1.36 × FFRmyo – 0.34. This equation provided no significant difference between corrected MRR and true MRR in the validation cohort. Pre‐PCI lower coronary flow reserve and higher index of microcirculatory resistance were independent predictors of pre‐PCI decreased true MRR. True MRR significantly decreased after PCI. In conclusion, MRR can be accurately corrected using an equation for FFRcor estimation without Pw. |
| first_indexed | 2024-03-09T01:09:00Z |
| format | Article |
| id | doaj.art-d712802608844be99ddd44ecde67cde6 |
| institution | Directory Open Access Journal |
| issn | 2051-817X |
| language | English |
| last_indexed | 2024-03-09T01:09:00Z |
| publishDate | 2023-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Physiological Reports |
| spelling | doaj.art-d712802608844be99ddd44ecde67cde62023-12-11T08:18:31ZengWileyPhysiological Reports2051-817X2023-03-01115n/an/a10.14814/phy2.15627Retracted: Microvascular resistance reserve in the presence of functionally significant epicardial stenosis and changes after revascularizationYoshihiro Hanyu0Masahiro Hoshino1Eisuke Usui2Tomoyo Sugiyama3Yoshihisa Kanaji4Masahiro Hada5Tatsuhiro Nagamine6Kai Nogami7Hiroki Ueno8Kodai Sayama9Kazuki Matsuda10Tatsuya Sakamoto11Taishi Yonetsu12Tetsuo Sasano13Tsunekazu Kakuta14Division of Cardiovascular Medicine Tsuchiura Kyodo General Hospital Ibaraki JapanDivision of Cardiovascular Medicine Tsuchiura Kyodo General Hospital Ibaraki JapanDivision of Cardiovascular Medicine Tsuchiura Kyodo General Hospital Ibaraki JapanDepartment of Interventional Cardiology Tokyo Medical and Dental University Tokyo JapanDivision of Cardiovascular Medicine Tsuchiura Kyodo General Hospital Ibaraki JapanDivision of Cardiovascular Medicine Tsuchiura Kyodo General Hospital Ibaraki JapanDivision of Cardiovascular Medicine Tsuchiura Kyodo General Hospital Ibaraki JapanDivision of Cardiovascular Medicine Tsuchiura Kyodo General Hospital Ibaraki JapanDivision of Cardiovascular Medicine Tsuchiura Kyodo General Hospital Ibaraki JapanDivision of Cardiovascular Medicine Tsuchiura Kyodo General Hospital Ibaraki JapanDivision of Cardiovascular Medicine Tsuchiura Kyodo General Hospital Ibaraki JapanDivision of Cardiovascular Medicine Tsuchiura Kyodo General Hospital Ibaraki JapanDepartment of Interventional Cardiology Tokyo Medical and Dental University Tokyo JapanDepartment of Cardiovascular Medicine Tokyo Medical and Dental University Tokyo JapanDivision of Cardiovascular Medicine Tsuchiura Kyodo General Hospital Ibaraki JapanAbstract In the presence of functionally significant epicardial lesions, microvascular resistance reserve (MRR) calculation needs incorporation of collateral flow. Coronary fractional flow reserve (FFRcor) requiring coronary wedge pressure (Pw), which is an essential part of the true MRR calculation, is reportedly estimated by myocardial FFR (FFRmyo) not requiring Pw measurement. We sought to find an equation to calculate MRR without the need for Pw. Furthermore, we assessed changes in MRR after percutaneous coronary intervention (PCI). An equation to estimate FFRcor was developed from a cohort of 230 patients who underwent physiological measurements and PCI. Corrected MRR was calculated using this equation and compared with true MRR in 115 patients of the different set of the validation cohort. True MRR was calculated using FFRcor. FFRcor and FFRmyo showed a strong linear relationship (r2 = 0.86) and an equation was FFRcor = 1.36 × FFRmyo – 0.34. This equation provided no significant difference between corrected MRR and true MRR in the validation cohort. Pre‐PCI lower coronary flow reserve and higher index of microcirculatory resistance were independent predictors of pre‐PCI decreased true MRR. True MRR significantly decreased after PCI. In conclusion, MRR can be accurately corrected using an equation for FFRcor estimation without Pw.https://doi.org/10.14814/phy2.15627chronic coronary syndromecoronary flow reservefractional flow reservemicrovascular resistance reservepercutaneous coronary intervention |
| spellingShingle | Yoshihiro Hanyu Masahiro Hoshino Eisuke Usui Tomoyo Sugiyama Yoshihisa Kanaji Masahiro Hada Tatsuhiro Nagamine Kai Nogami Hiroki Ueno Kodai Sayama Kazuki Matsuda Tatsuya Sakamoto Taishi Yonetsu Tetsuo Sasano Tsunekazu Kakuta Retracted: Microvascular resistance reserve in the presence of functionally significant epicardial stenosis and changes after revascularization Physiological Reports chronic coronary syndrome coronary flow reserve fractional flow reserve microvascular resistance reserve percutaneous coronary intervention |
| title | Retracted: Microvascular resistance reserve in the presence of functionally significant epicardial stenosis and changes after revascularization |
| title_full | Retracted: Microvascular resistance reserve in the presence of functionally significant epicardial stenosis and changes after revascularization |
| title_fullStr | Retracted: Microvascular resistance reserve in the presence of functionally significant epicardial stenosis and changes after revascularization |
| title_full_unstemmed | Retracted: Microvascular resistance reserve in the presence of functionally significant epicardial stenosis and changes after revascularization |
| title_short | Retracted: Microvascular resistance reserve in the presence of functionally significant epicardial stenosis and changes after revascularization |
| title_sort | retracted microvascular resistance reserve in the presence of functionally significant epicardial stenosis and changes after revascularization |
| topic | chronic coronary syndrome coronary flow reserve fractional flow reserve microvascular resistance reserve percutaneous coronary intervention |
| url | https://doi.org/10.14814/phy2.15627 |
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