Neuromapping olfactory stimulation using magnetoencephalography - visualizing smell, a proof-of-concept study
ImportanceCurrently, clinical assessment of olfaction is largely reliant on subjective methods that require patient participation. The objective method for measuring olfaction, using electroencephalogram (EEG) readings, can be supplemented with the improved temporal resolution of magnetoencephalogra...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Allergy |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/falgy.2022.1019265/full |
| _version_ | 1828067957314420736 |
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| author | Rahilla Tarfa Rahilla Tarfa Sophie E. Yu Omar H. Ahmed John A. Moore Ricardo Bruña Nathalia Velasquez Alexander J. Poplawsky Brian A. Coffman Stella E. Lee |
| author_facet | Rahilla Tarfa Rahilla Tarfa Sophie E. Yu Omar H. Ahmed John A. Moore Ricardo Bruña Nathalia Velasquez Alexander J. Poplawsky Brian A. Coffman Stella E. Lee |
| author_sort | Rahilla Tarfa |
| collection | DOAJ |
| description | ImportanceCurrently, clinical assessment of olfaction is largely reliant on subjective methods that require patient participation. The objective method for measuring olfaction, using electroencephalogram (EEG) readings, can be supplemented with the improved temporal resolution of magnetoencephalography (MEG) for olfactory measurement that can delineate cortical and peripheral olfactory loss. MEG provides high temporal and spatial resolution which can enhance our understanding of central olfactory processing compared to using EEG alone.ObjectiveTo determine the feasibility of building an in-house portable olfactory stimulator paired with electrophysiological neuroimaging technique with MEG to assess olfaction in the clinical setting.Design, setting and participantsThis proof-of-concept study utilized a paired MEG-olfactometer paradigm to assess olfaction in three normosmic participants. We used a two-channel olfactory stimulator to deliver odorants according to a programmed stimulus-rest paradigm. Two synthetic odorants: 2% phenethyl alcohol (rose) and 0.5% amyl acetate (banana) were delivered in increasing increments of time followed by periods of rest. Cortical activity was measured via a 306-channel MEG system.Main outcomes and measuresPrimary outcome measure was the relative spectral power for each frequency band, which was contrasted between rest and olfactory stimulation.ResultsCompared to rest, olfactory stimulation produced a 40% increase in relative alpha power within the olfactory cortex bilaterally with both odorants. A 25%–30% increase in relative alpha power occurred in the left orbitofrontal cortex and precentral gyrus with phenethyl alcohol stimulation but not amyl acetate.Conclusion and relevanceIn this proof-of-concept study, we demonstrate the feasibility of olfactory measurement via an olfactometer-MEG paradigm. We found that odorant-specific cortical signatures can be identified using this paradigm, setting the basis for further investigation of this system as a prognostic tool for olfactory loss. |
| first_indexed | 2024-04-10T23:54:59Z |
| format | Article |
| id | doaj.art-d714df8e6f734dd7803de6d60fdfebe8 |
| institution | Directory Open Access Journal |
| issn | 2673-6101 |
| language | English |
| last_indexed | 2024-04-10T23:54:59Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Allergy |
| spelling | doaj.art-d714df8e6f734dd7803de6d60fdfebe82023-01-10T14:42:20ZengFrontiers Media S.A.Frontiers in Allergy2673-61012023-01-01310.3389/falgy.2022.10192651019265Neuromapping olfactory stimulation using magnetoencephalography - visualizing smell, a proof-of-concept studyRahilla Tarfa0Rahilla Tarfa1Sophie E. Yu2Omar H. Ahmed3John A. Moore4Ricardo Bruña5Nathalia Velasquez6Alexander J. Poplawsky7Brian A. Coffman8Stella E. Lee9University of Pittsburgh School of Medicine, Pittsburgh, PA, United StatesDepartment of Otolaryngology – Head and Neck Surgery, University of Pittsburgh Medical Center (UPMC), Pittsburgh, PA, United StatesDepartment of Otolaryngology – Head & Neck Surgery, Harvard Medical School, Boston, MA, United StatesPenn Medicine Becker ENT & Allergy, Robbinsville, NJ, United StatesDepartment of Otolaryngology – Head and Neck Surgery, University of Pittsburgh Medical Center (UPMC), Pittsburgh, PA, United StatesDepartment of Radiology, Universidad Complutense de Madrid (UCM), IdISSC, Madrid, SpainDepartment of Otolaryngology, Cleveland Clinic Florida, Weston, FL, United StatesCenter for Neuroscience, McGowan Institute of Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, United StatesDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, United StatesDivision of Otolaryngology – Head & Neck Surgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United StatesImportanceCurrently, clinical assessment of olfaction is largely reliant on subjective methods that require patient participation. The objective method for measuring olfaction, using electroencephalogram (EEG) readings, can be supplemented with the improved temporal resolution of magnetoencephalography (MEG) for olfactory measurement that can delineate cortical and peripheral olfactory loss. MEG provides high temporal and spatial resolution which can enhance our understanding of central olfactory processing compared to using EEG alone.ObjectiveTo determine the feasibility of building an in-house portable olfactory stimulator paired with electrophysiological neuroimaging technique with MEG to assess olfaction in the clinical setting.Design, setting and participantsThis proof-of-concept study utilized a paired MEG-olfactometer paradigm to assess olfaction in three normosmic participants. We used a two-channel olfactory stimulator to deliver odorants according to a programmed stimulus-rest paradigm. Two synthetic odorants: 2% phenethyl alcohol (rose) and 0.5% amyl acetate (banana) were delivered in increasing increments of time followed by periods of rest. Cortical activity was measured via a 306-channel MEG system.Main outcomes and measuresPrimary outcome measure was the relative spectral power for each frequency band, which was contrasted between rest and olfactory stimulation.ResultsCompared to rest, olfactory stimulation produced a 40% increase in relative alpha power within the olfactory cortex bilaterally with both odorants. A 25%–30% increase in relative alpha power occurred in the left orbitofrontal cortex and precentral gyrus with phenethyl alcohol stimulation but not amyl acetate.Conclusion and relevanceIn this proof-of-concept study, we demonstrate the feasibility of olfactory measurement via an olfactometer-MEG paradigm. We found that odorant-specific cortical signatures can be identified using this paradigm, setting the basis for further investigation of this system as a prognostic tool for olfactory loss.https://www.frontiersin.org/articles/10.3389/falgy.2022.1019265/fullolfactionneurologicalmagnetoencephalagraphy (MEG)electroencephalography (EEG)device |
| spellingShingle | Rahilla Tarfa Rahilla Tarfa Sophie E. Yu Omar H. Ahmed John A. Moore Ricardo Bruña Nathalia Velasquez Alexander J. Poplawsky Brian A. Coffman Stella E. Lee Neuromapping olfactory stimulation using magnetoencephalography - visualizing smell, a proof-of-concept study Frontiers in Allergy olfaction neurological magnetoencephalagraphy (MEG) electroencephalography (EEG) device |
| title | Neuromapping olfactory stimulation using magnetoencephalography - visualizing smell, a proof-of-concept study |
| title_full | Neuromapping olfactory stimulation using magnetoencephalography - visualizing smell, a proof-of-concept study |
| title_fullStr | Neuromapping olfactory stimulation using magnetoencephalography - visualizing smell, a proof-of-concept study |
| title_full_unstemmed | Neuromapping olfactory stimulation using magnetoencephalography - visualizing smell, a proof-of-concept study |
| title_short | Neuromapping olfactory stimulation using magnetoencephalography - visualizing smell, a proof-of-concept study |
| title_sort | neuromapping olfactory stimulation using magnetoencephalography visualizing smell a proof of concept study |
| topic | olfaction neurological magnetoencephalagraphy (MEG) electroencephalography (EEG) device |
| url | https://www.frontiersin.org/articles/10.3389/falgy.2022.1019265/full |
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