Characterization of the antibiotic doripenem using physicochemical methods: chromatography, spectrophotometry, spectroscopy and thermal analysis

Characterization of the antibiotic doripenem using physicochemical methods: chromatography, spectrophotometry, spectroscopy and thermal analysis

Doripenem was characterized through physicochemical and spectroscopic techniques, as well as thermal analysis. TLC (Rf = 0.62) and HPLC (rt = 7.4 min) were found to be adequate to identify the drug. UV and infrared spectra showed similar profile between doripenem bulk and standard. The ¹H and 13C NM...

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Bibliographic Details
Main Authors: Andreas S. L Mendez, Luciano Mantovani, Fábio Barbosa, Carla T. M Sayago, Cássia V Garcia, Fávero R Paula, Fabiana E. B. da Silva, Elton L. G Denardin, Elfrides E. S Schapoval
Format: Article
Language:English
Published: Sociedade Brasileira de Química 2011-09-01
Series:Química Nova
Subjects:
doripenem
qualitative analysis
physicochemical methods
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000900024&lng=en&tlng=en

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