Effect of Spinally Administered Simvastatin on the Formalin-Induced Nociceptive Response in Mice
Clinical and experimental observations indicated that 3-hydroxy-3-methylglutaryl CoA reductase inhibitor statins have pleiotropic effects. The present study determined the antinociceptive property of centrally administered simvastatin on the formalin-induced nociception in the mouse. Intrathecal adm...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2012-01-01
|
| Series: | Journal of Pharmacological Sciences |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861319305298 |
| _version_ | 1811230926400651264 |
|---|---|
| author | Masahiro Ohsawa Junpei Mutoh Shohei Yamamoto Hideki Ono Hiroaki Hisa |
| author_facet | Masahiro Ohsawa Junpei Mutoh Shohei Yamamoto Hideki Ono Hiroaki Hisa |
| author_sort | Masahiro Ohsawa |
| collection | DOAJ |
| description | Clinical and experimental observations indicated that 3-hydroxy-3-methylglutaryl CoA reductase inhibitor statins have pleiotropic effects. The present study determined the antinociceptive property of centrally administered simvastatin on the formalin-induced nociception in the mouse. Intrathecal administration of simvastatin at doses of 0.5 – 50 nmol dose-dependently attenuated the second, but not the first, phase of the formalin-induced nociception, which was partially reversed by mevalonate (5 μmol). Intracerebroventricular injection of simvastatin (50 nmol) did not affect the formalin-induced nociception. These results suggest that simvastatin-induced antinociception is mediated by attenuation of the sensitization of spinal nociceptive transmission. Keywords:: simvastatin, spinal cord, inflammation |
| first_indexed | 2024-04-12T10:36:20Z |
| format | Article |
| id | doaj.art-d7167e25c6e244c4a4ae5a11c0099788 |
| institution | Directory Open Access Journal |
| issn | 1347-8613 |
| language | English |
| last_indexed | 2024-04-12T10:36:20Z |
| publishDate | 2012-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pharmacological Sciences |
| spelling | doaj.art-d7167e25c6e244c4a4ae5a11c00997882022-12-22T03:36:42ZengElsevierJournal of Pharmacological Sciences1347-86132012-01-011191102106Effect of Spinally Administered Simvastatin on the Formalin-Induced Nociceptive Response in MiceMasahiro Ohsawa0Junpei Mutoh1Shohei Yamamoto2Hideki Ono3Hiroaki Hisa4Second Department of Pharmacology, School of Pharmaceutical Sciences, Kyushu University of Health and Welfare, 1714-1 Yoshino-machi, Nobeoka-shi, Miyazaki 882-8508, Japan; Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan; Corresponding author. ohsawa@phar.nagoya-cu.ac.jp on April 18, 2012 (in advance)Second Department of Pharmacology, School of Pharmaceutical Sciences, Kyushu University of Health and Welfare, 1714-1 Yoshino-machi, Nobeoka-shi, Miyazaki 882-8508, JapanLaboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya 467-8603, JapanLaboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya 467-8603, JapanSecond Department of Pharmacology, School of Pharmaceutical Sciences, Kyushu University of Health and Welfare, 1714-1 Yoshino-machi, Nobeoka-shi, Miyazaki 882-8508, JapanClinical and experimental observations indicated that 3-hydroxy-3-methylglutaryl CoA reductase inhibitor statins have pleiotropic effects. The present study determined the antinociceptive property of centrally administered simvastatin on the formalin-induced nociception in the mouse. Intrathecal administration of simvastatin at doses of 0.5 – 50 nmol dose-dependently attenuated the second, but not the first, phase of the formalin-induced nociception, which was partially reversed by mevalonate (5 μmol). Intracerebroventricular injection of simvastatin (50 nmol) did not affect the formalin-induced nociception. These results suggest that simvastatin-induced antinociception is mediated by attenuation of the sensitization of spinal nociceptive transmission. Keywords:: simvastatin, spinal cord, inflammationhttp://www.sciencedirect.com/science/article/pii/S1347861319305298 |
| spellingShingle | Masahiro Ohsawa Junpei Mutoh Shohei Yamamoto Hideki Ono Hiroaki Hisa Effect of Spinally Administered Simvastatin on the Formalin-Induced Nociceptive Response in Mice Journal of Pharmacological Sciences |
| title | Effect of Spinally Administered Simvastatin on the Formalin-Induced Nociceptive Response in Mice |
| title_full | Effect of Spinally Administered Simvastatin on the Formalin-Induced Nociceptive Response in Mice |
| title_fullStr | Effect of Spinally Administered Simvastatin on the Formalin-Induced Nociceptive Response in Mice |
| title_full_unstemmed | Effect of Spinally Administered Simvastatin on the Formalin-Induced Nociceptive Response in Mice |
| title_short | Effect of Spinally Administered Simvastatin on the Formalin-Induced Nociceptive Response in Mice |
| title_sort | effect of spinally administered simvastatin on the formalin induced nociceptive response in mice |
| url | http://www.sciencedirect.com/science/article/pii/S1347861319305298 |
| work_keys_str_mv | AT masahiroohsawa effectofspinallyadministeredsimvastatinontheformalininducednociceptiveresponseinmice AT junpeimutoh effectofspinallyadministeredsimvastatinontheformalininducednociceptiveresponseinmice AT shoheiyamamoto effectofspinallyadministeredsimvastatinontheformalininducednociceptiveresponseinmice AT hidekiono effectofspinallyadministeredsimvastatinontheformalininducednociceptiveresponseinmice AT hiroakihisa effectofspinallyadministeredsimvastatinontheformalininducednociceptiveresponseinmice |