Effect of Spinally Administered Simvastatin on the Formalin-Induced Nociceptive Response in Mice

Effect of Spinally Administered Simvastatin on the Formalin-Induced Nociceptive Response in Mice

Clinical and experimental observations indicated that 3-hydroxy-3-methylglutaryl CoA reductase inhibitor statins have pleiotropic effects. The present study determined the antinociceptive property of centrally administered simvastatin on the formalin-induced nociception in the mouse. Intrathecal adm...

Full description

Bibliographic Details
Main Authors:	Masahiro Ohsawa, Junpei Mutoh, Shohei Yamamoto, Hideki Ono, Hiroaki Hisa
Format:	Article
Language:	English
Published:	Elsevier 2012-01-01
Series:	Journal of Pharmacological Sciences
Online Access:	http://www.sciencedirect.com/science/article/pii/S1347861319305298

Similar Items

Involvement of Renal Sympathetic Nerve Activation on the Progression of Ischemic Acute Kidney Injury in the Mouse
by: Junpei Mutoh, et al.
Published: (2014-01-01)

Effects of silymarin on neuropathic pain and formalin-induced nociception in mice
by: Faezeh Vahdati Hassani, et al.
Published: (2015-07-01)

Gabapentin Prevents Oxaliplatin-Induced Mechanical Hyperalgesia in Mice
by: Masahiro Ohsawa, et al.
Published: (2014-01-01)

Sertraline inhibits formalin-induced nociception and cardiovascular responses
by: C.H. Santuzzi, et al.
Published: (2012-01-01)

Sertraline inhibits formalin-induced nociception and cardiovascular responses
by: C.H. Santuzzi, et al.
Published: (2012-01-01)

Anti-nociceptive Activity of Quebracho tannin Extract on Pain Induced by Formalin and Writhing Tests in Mice
by: Fatemeh Zare, et al.
Published: (2021-12-01)

Preliminary study on antinociceptove effect of aqueous extract of Boesenbergia pandurata in formalin-induced nociception test in mice
by: Ee, Ai Chin, et al.
Published: (2014)

Characterization of Nociceptive Behaviors Induced by Formalin in the Glabrous and Hairy Skin of Rats
by: Elaheh Erami, et al.
Published: (2017-01-01)

The Effects of Testosterone and Gonadectomy Conditions on Nociception and Their Effect on Morphine-Induced Analgesia in Male Mice, Using the formalin test
by: N Yousofvand, et al.
Published: (2010-10-01)

Antinociceptive and antineuropathic effects of Trifolium resupinatum L. on formalin-induced nociception and cervical spinal cord hemi-contusion: Underlying Mechanisms
by: Sajjad Jabbari, et al.
Published: (2024)

Oxaliplatin treatment changes the function of sensory nerves in rats
by: Shohei Yamamoto, et al.
Published: (2016-04-01)

The Possible Anti-nociceptive Effect of Troxerutin and Neural Interactions Using Formalin and Writhing Tests in Mice
by: Farima Jafari-Tirabadi, et al.
Published: (2023-06-01)

Ethyl pyruvate attenuates formalin-induced inflammatory nociception by inhibiting neuronal ERK phosphorylation
by: Lee Min, et al.
Published: (2012-05-01)

Contribution of Histamine to Nociceptive Behaviors Induced by Intrathecally Administered Cholecystokinin-8
by: Takafumi Hayashi, et al.
Published: (2020-10-01)

Dexmedetomidine Co-Administered with Lidocaine Decreases Nociceptive Responses and Trigeminal Fos Expression without Motor Dysfunction and Hypotension in a Murine Orofacial Formalin Model
by: Ji-Hee Yeo, et al.
Published: (2022-01-01)

Anti-nociceptive Activity of L-citrulline in Mice Using Formalin and Hot Plate Tests: Possible Mechanism of Action
by: Pegah Haramipour, et al.
Published: (2022-12-01)

Presynaptic Inhibitory Effects of Fluvoxamine, a Selective Serotonin Reuptake Inhibitor, on Nociceptive Excitatory Synaptic Transmission in Spinal Superficial Dorsal Horn Neurons of Adult Mice
by: Orie Tomoyose, et al.
Published: (2014-01-01)

The Effect of Food Deprivation on Nociception in Formalin Test and Plasma Levels of Noradrenaline and Corticosterone in Rats
by: Nematollah Gheibi, et al.
Published: (2013-11-01)

Anti-nociceptive Activity of Regenerated Drosera spatulata Aqueous Extract by Rat Formalin Test
by: S Golabi, et al.
Published: (2010-03-01)

Simvastatin and Ezetimibe-Loaded Nanofibers Administered Locally to Augment Bone Healing
by: Shayan Amiri, et al.
Published: (2021-01-01)

Effect of Exposure to Chronic Heterogeneous Sequential Stress during Prenatal on Formalin-Induced Nociceptive Behaviour in Adult Offspring in Rats
by: Farzad Rajaei, et al.
Published: (2013-12-01)

Reduction of joint nociception induced by formalin in rats treated ith low level laser therapy 670 or 830 nm
by: Jhenifer Karvat, et al.
Published: (2015-12-01)

Neurokinin receptor mechanisms in forebrain medial septum modulate nociception in the formalin model of inflammatory pain
by: Si Yun Ng, et al.
Published: (2021-12-01)

Systemic Administration of Minocycline Reduces Fos Protein Expression in Rapid Eye Movement (REM) Sleep Deprived Rat’s Spinal Cord But Not Nociceptive Response After Formalin-Induced Inflammatory Pain
by: Long, Idris, et al.
Published: (2017)

Effects of Intra-BLA Administration of PPAR Antagonists on Formalin-Evoked Nociceptive Behaviour, Fear-Conditioned Analgesia, and Conditioned Fear in the Presence or Absence of Nociceptive Tone in Rats
by: Jessica C. Gaspar, et al.
Published: (2022-03-01)

Galectin-3 activates spinal microglia to induce inflammatory nociception in wild type but not in mice modelling Alzheimer’s disease
by: George Sideris-Lampretsas, et al.
Published: (2023-06-01)

N- and L-Type Voltage-Dependent Ca2+ Channels Contribute to the Generation of After-Discharges in the Spinal Ventral Root After Cessation of Noxious Mechanical Stimulation
by: Shohei Yamamoto, et al.
Published: (2012-01-01)

Enhanced Wind-Up of the C-Fiber-Mediated Nociceptive Flexor Reflex Movement Following Painful Diabetic Neuropathy in Mice
by: Satoko Kimura, et al.
Published: (2005-01-01)

Is blood glucose associated with descending modulation of spinal nociception as measured by the nociceptive flexion reflex?
by: Terry EL, et al.
Published: (2016-04-01)

Formalin Itch Test: Low-Dose Formalin Induces Histamine-Independent, TRPA1-Mediated Itch in Mice
by: Xu Liu, et al.
Published: (2021-02-01)

Glycine Receptors in Spinal Nociceptive Control—An Update
by: Hanns Ulrich Zeilhofer, et al.
Published: (2021-06-01)

Simvastatin attenuates radiation-induced salivary gland dysfunction in mice
by: Xu L, et al.
Published: (2016-07-01)

Quercetin Inhibits Peripheral and Spinal Cord Nociceptive Mechanisms to Reduce Intense Acute Swimming-Induced Muscle Pain in Mice.
by: Sergio M Borghi, et al.
Published: (2016-01-01)

Investigation of noradrenergic receptor system in anti-nociception using formalin test in the naked mole rat (Heterocephalus glaber)
by: R.M. Mwobobia, et al.
Published: (2020-10-01)

Modification of κ-Opioid Receptor Agonist-Induced Antinociception by Diabetes in the Mouse Brain and Spinal Cord
by: Masahiro Ohsawa, et al.
Published: (2005-01-01)

Effect of Mexiletine on Fenvalerate-Induced Nociceptive Response in Diabetic Mice
by: Junzo Kamei, et al.
Published: (2004-01-01)

Termination of Nociceptive Bahaviour at the End of Phase 2 of Formalin Test is Attributable to Endogenous Inhibitory Mechanisms, but not by Opioid Receptors Activation
by: Hassan Azhdari-Zarmehri, et al.
Published: (2014-02-01)

Application of calibrated forceps for assessing mechanical nociception with high time resolution in mice.
by: Hideki Kashiwadani, et al.
Published: (2017-01-01)

The effect of verapamil, nifedipine and diltiazem on formalin-induced pain response in mice
by: M.H Khayat Nouri, et al.
Published: (2009-11-01)

EFFECTS OF ADENOSINE RECEPTOR LIGANDS ON THE NOCICEPTION AND STRESS-INDUCED ANTINOCICEPTION IN MICE
by: Lubomira Ivanova, et al.
Published: (2019-02-01)