Neural mechanisms of economic choices in mice
Economic choices entail computing and comparing subjective values. Evidence from primates indicates that this behavior relies on the orbitofrontal cortex. Conversely, previous work in rodents provided conflicting results. Here we present a mouse model of economic choice behavior, and we show that th...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
eLife Sciences Publications Ltd
2020-02-01
|
| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/49669 |
| _version_ | 1818019903286804480 |
|---|---|
| author | Masaru Kuwabara Ningdong Kang Timothy E Holy Camillo Padoa-Schioppa |
| author_facet | Masaru Kuwabara Ningdong Kang Timothy E Holy Camillo Padoa-Schioppa |
| author_sort | Masaru Kuwabara |
| collection | DOAJ |
| description | Economic choices entail computing and comparing subjective values. Evidence from primates indicates that this behavior relies on the orbitofrontal cortex. Conversely, previous work in rodents provided conflicting results. Here we present a mouse model of economic choice behavior, and we show that the lateral orbital (LO) area is intimately related to the decision process. In the experiments, mice chose between different juices offered in variable amounts. Choice patterns closely resembled those measured in primates. Optogenetic inactivation of LO dramatically disrupted choices by inducing erratic changes of relative value and by increasing choice variability. Neuronal recordings revealed that different groups of cells encoded the values of individual options, the binary choice outcome and the chosen value. These groups match those previously identified in primates, except that the neuronal representation in mice is spatial (in monkeys it is good-based). Our results lay the foundations for a circuit-level analysis of economic decisions. |
| first_indexed | 2024-04-14T07:57:57Z |
| format | Article |
| id | doaj.art-d717aeec9d8d48948fb60fec91998fe5 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-14T07:57:57Z |
| publishDate | 2020-02-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-d717aeec9d8d48948fb60fec91998fe52022-12-22T02:04:59ZengeLife Sciences Publications LtdeLife2050-084X2020-02-01910.7554/eLife.49669Neural mechanisms of economic choices in miceMasaru Kuwabara0Ningdong Kang1Timothy E Holy2Camillo Padoa-Schioppa3https://orcid.org/0000-0002-7519-8790Department of Neuroscience, Washington University, Saint Louis, United StatesDepartment of Neuroscience, Washington University, Saint Louis, United StatesDepartment of Neuroscience, Washington University, Saint Louis, United StatesDepartment of Neuroscience, Washington University, Saint Louis, United StatesEconomic choices entail computing and comparing subjective values. Evidence from primates indicates that this behavior relies on the orbitofrontal cortex. Conversely, previous work in rodents provided conflicting results. Here we present a mouse model of economic choice behavior, and we show that the lateral orbital (LO) area is intimately related to the decision process. In the experiments, mice chose between different juices offered in variable amounts. Choice patterns closely resembled those measured in primates. Optogenetic inactivation of LO dramatically disrupted choices by inducing erratic changes of relative value and by increasing choice variability. Neuronal recordings revealed that different groups of cells encoded the values of individual options, the binary choice outcome and the chosen value. These groups match those previously identified in primates, except that the neuronal representation in mice is spatial (in monkeys it is good-based). Our results lay the foundations for a circuit-level analysis of economic decisions.https://elifesciences.org/articles/49669decision makingoptogeneticsneurophysiologyneuroeconomicssubjective valueorbitofrontal cortex |
| spellingShingle | Masaru Kuwabara Ningdong Kang Timothy E Holy Camillo Padoa-Schioppa Neural mechanisms of economic choices in mice eLife decision making optogenetics neurophysiology neuroeconomics subjective value orbitofrontal cortex |
| title | Neural mechanisms of economic choices in mice |
| title_full | Neural mechanisms of economic choices in mice |
| title_fullStr | Neural mechanisms of economic choices in mice |
| title_full_unstemmed | Neural mechanisms of economic choices in mice |
| title_short | Neural mechanisms of economic choices in mice |
| title_sort | neural mechanisms of economic choices in mice |
| topic | decision making optogenetics neurophysiology neuroeconomics subjective value orbitofrontal cortex |
| url | https://elifesciences.org/articles/49669 |
| work_keys_str_mv | AT masarukuwabara neuralmechanismsofeconomicchoicesinmice AT ningdongkang neuralmechanismsofeconomicchoicesinmice AT timothyeholy neuralmechanismsofeconomicchoicesinmice AT camillopadoaschioppa neuralmechanismsofeconomicchoicesinmice |