Gut Microbiota Composition in Obese and Normal Weight Adults in Iran
Background and purpose: Increasing prevalence of obesity over the past few decades constitutes a global health challenge. Recent evidence suggests that gut microbiota may contribute to weight control. So, the present study aimed at comparing the frequency of different bacteria in gut microbiota betw...
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| Format: | Article |
| Language: | English |
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Mazandaran University of Medical Sciences
2021-01-01
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| Series: | Journal of Mazandaran University of Medical Sciences |
| Subjects: | |
| Online Access: | http://jmums.mazums.ac.ir/article-1-16051-en.html |
| _version_ | 1828069840717348864 |
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| author | Hanieh-Sadat Ejtahed Zahra Hoseini Tavassol Shirin Hasani-Ranjbar Ahmad-Reza Soroush Seyed Davar Siadat Bagher Larijani |
| author_facet | Hanieh-Sadat Ejtahed Zahra Hoseini Tavassol Shirin Hasani-Ranjbar Ahmad-Reza Soroush Seyed Davar Siadat Bagher Larijani |
| author_sort | Hanieh-Sadat Ejtahed |
| collection | DOAJ |
| description | Background and purpose: Increasing prevalence of obesity over the past few decades constitutes a global health challenge. Recent evidence suggests that gut microbiota may contribute to weight control. So, the present study aimed at comparing the frequency of different bacteria in gut microbiota between obese and normal weight people in Iran.
Materials and methods: Thirty normal weight (BMI of 18.5- 25 kg/m²) and 27 obese adults (BMI of 30 kg/m² or higher) were included in this case-control study. Dietary intake was assessed using food frequency questionnaire (FFQ). Anthropometric measurements and collection of blood and faecal samples were also done. Then, gut microbiota composition was assessed using quantitative real-time PCR.
Results: The mean age of participants and concentrations of fasting blood glucose and insulin, insulin resistance index, triglyceride concentration and hsCRP were higher in obese group than the normal group (P<0.05). The frequency of Akkermansia was significantly higher in individuals with normal weight than obese individuals (P=0.003). On the other hand, the frequencies of Prevotella and Lactobacillus genera were higher in obese individuals (P>0.05).
Conclusion: In this study, the frequencies of some bacterial genera of intestinal microbiota were significantly different between obese and normal weight individuals. Therefore, population-based studies are needed to confirm current findings. Moreover, in order to achieve personalized medicine goals, information on gut microbiota composition could be helpful. |
| first_indexed | 2024-04-11T00:25:34Z |
| format | Article |
| id | doaj.art-d718f6c99e354823b5bcd464cec61c90 |
| institution | Directory Open Access Journal |
| issn | 1735-9260 1735-9279 |
| language | English |
| last_indexed | 2024-04-11T00:25:34Z |
| publishDate | 2021-01-01 |
| publisher | Mazandaran University of Medical Sciences |
| record_format | Article |
| series | Journal of Mazandaran University of Medical Sciences |
| spelling | doaj.art-d718f6c99e354823b5bcd464cec61c902023-01-08T08:42:38ZengMazandaran University of Medical SciencesJournal of Mazandaran University of Medical Sciences1735-92601735-92792021-01-01301931220Gut Microbiota Composition in Obese and Normal Weight Adults in IranHanieh-Sadat Ejtahed0Zahra Hoseini Tavassol1Shirin Hasani-Ranjbar2Ahmad-Reza Soroush3Seyed Davar Siadat4Bagher Larijani5 Assistant Professor, Obesity and Eating Habits Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran 2 Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran 3 PhD candidate in Medical Biotechnology, Obesity and Eating Habits Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran 4 Department of Mycobacteriology and Pulmonary Research, Microbiology Research Center, Pasteur Institute of Iran, Tehran, Iran Professor, Obesity and Eating Habits Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran Professor, Obesity and Eating Habits Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran Professor, Department of Mycobacteriology and Pulmonary Research, Microbiology Research Center, Pasteur Institute of Iran, Tehran, Iran.Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran Professor, Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran Background and purpose: Increasing prevalence of obesity over the past few decades constitutes a global health challenge. Recent evidence suggests that gut microbiota may contribute to weight control. So, the present study aimed at comparing the frequency of different bacteria in gut microbiota between obese and normal weight people in Iran. Materials and methods: Thirty normal weight (BMI of 18.5- 25 kg/m²) and 27 obese adults (BMI of 30 kg/m² or higher) were included in this case-control study. Dietary intake was assessed using food frequency questionnaire (FFQ). Anthropometric measurements and collection of blood and faecal samples were also done. Then, gut microbiota composition was assessed using quantitative real-time PCR. Results: The mean age of participants and concentrations of fasting blood glucose and insulin, insulin resistance index, triglyceride concentration and hsCRP were higher in obese group than the normal group (P<0.05). The frequency of Akkermansia was significantly higher in individuals with normal weight than obese individuals (P=0.003). On the other hand, the frequencies of Prevotella and Lactobacillus genera were higher in obese individuals (P>0.05). Conclusion: In this study, the frequencies of some bacterial genera of intestinal microbiota were significantly different between obese and normal weight individuals. Therefore, population-based studies are needed to confirm current findings. Moreover, in order to achieve personalized medicine goals, information on gut microbiota composition could be helpful.http://jmums.mazums.ac.ir/article-1-16051-en.htmlgut microbiotamicrobiomeobesitynormal weight |
| spellingShingle | Hanieh-Sadat Ejtahed Zahra Hoseini Tavassol Shirin Hasani-Ranjbar Ahmad-Reza Soroush Seyed Davar Siadat Bagher Larijani Gut Microbiota Composition in Obese and Normal Weight Adults in Iran Journal of Mazandaran University of Medical Sciences gut microbiota microbiome obesity normal weight |
| title | Gut Microbiota Composition in Obese and Normal
Weight Adults in Iran |
| title_full | Gut Microbiota Composition in Obese and Normal
Weight Adults in Iran |
| title_fullStr | Gut Microbiota Composition in Obese and Normal
Weight Adults in Iran |
| title_full_unstemmed | Gut Microbiota Composition in Obese and Normal
Weight Adults in Iran |
| title_short | Gut Microbiota Composition in Obese and Normal
Weight Adults in Iran |
| title_sort | gut microbiota composition in obese and normal weight adults in iran |
| topic | gut microbiota microbiome obesity normal weight |
| url | http://jmums.mazums.ac.ir/article-1-16051-en.html |
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