EOAI, a ubiquitin-specific peptidase 5 inhibitor, prevents non-small cell lung cancer progression by inducing DNA damage

EOAI, a ubiquitin-specific peptidase 5 inhibitor, prevents non-small cell lung cancer progression by inducing DNA damage

Abstract Objective Targeting deubiquitinases (DUBs) has emerged as a promising avenue for anticancer drug development. However, the effect and mechanism of pan-DUB inhibitor EOAI on non-small cell lung cancer (NSCLC) remains to be studied. Materials and methods The expression of ubiquitin-specific p...

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Bibliographic Details
Main Authors: Yuanyuan Zheng, Longhao Wang, Xiaoyu Niu, Yongjun Guo, Jiuzhou Zhao, Lifeng Li, Jie Zhao
Format: Article
Language:English
Published: BMC 2023-01-01
Series:BMC Cancer
Subjects:
Non-small cell lung cancer
DNA damage
USP5 inhibitor
Apoptosis
Autophagy
Online Access:https://doi.org/10.1186/s12885-023-10506-0

Internet

https://doi.org/10.1186/s12885-023-10506-0

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