PCNA Unloading Is Crucial for the Bypass of DNA Lesions Using Homologous Recombination

PCNA Unloading Is Crucial for the Bypass of DNA Lesions Using Homologous Recombination

DNA Damage Tolerance (DDT) mechanisms allow cells to bypass lesions in the DNA during replication. This allows the cells to progress normally through the cell cycle in the face of abnormalities in their DNA. PCNA, a homotrimeric sliding clamp complex, plays a central role in the coordination of vari...

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Bibliographic Details
Main Authors: Matan Arbel-Groissman, Batia Liefshitz, Nir Katz, Maxim Kuryachiy, Martin Kupiec
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:International Journal of Molecular Sciences
Subjects:
<i>Saccharomyces cerevisiae</i>
DNA repair
DNA damage bypass
post-replicational repair
PCNA
Elg1
Online Access:https://www.mdpi.com/1422-0067/25/6/3359

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