TPM1 mediates inflammation downstream of TREM2 via the PKA/CREB signaling pathway

TPM1 mediates inflammation downstream of TREM2 via the PKA/CREB signaling pathway

Abstract Background Microglia, the innate immune cells in the central nervous system, play an essential role in brain homeostasis, neuroinflammation and brain infections. Dysregulated microglia, on the other hand, are associated with neurodegenerative diseases, yet the mechanisms underlying pro-infl...

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Bibliographic Details
Main Authors: Rong Li, Jing Zhang, Qiong Wang, Meng Cheng, Bin Lin
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Journal of Neuroinflammation
Subjects:
Retina
Tropomyosin 1
Inflammation
TREM2
CREB
Online Access:https://doi.org/10.1186/s12974-022-02619-3

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