Free 25-Vitamin D Is Correlated with Cardiovascular Events in Prevalent Hemodialysis Patients but Not with Markers of Renal Mineral Bone Disease
Free vitamin D is the biologically active form of vitamin D. Vitamin D deficiency is associated with cardiovascular disease, the most common cause of mortality in hemodialysis patients. The goal of our current study was to investigate the relation between blood concentrations of free 25-hydroxyvitam...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2019-06-01
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| Series: | Kidney & Blood Pressure Research |
| Subjects: | |
| Online Access: | https://www.karger.com/Article/FullText/499878 |
| _version_ | 1828759275618435072 |
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| author | Xin Chen Yong-Ping Lu Ting Luo Hong-Wei Wu Su-Fen Cai Mei Tian Liang-Hong Yin Bernhard K. Krämer Fan-Na Liu Berthold Hocher Saban Elitok |
| author_facet | Xin Chen Yong-Ping Lu Ting Luo Hong-Wei Wu Su-Fen Cai Mei Tian Liang-Hong Yin Bernhard K. Krämer Fan-Na Liu Berthold Hocher Saban Elitok |
| author_sort | Xin Chen |
| collection | DOAJ |
| description | Free vitamin D is the biologically active form of vitamin D. Vitamin D deficiency is associated with cardiovascular disease, the most common cause of mortality in hemodialysis patients. The goal of our current study was to investigate the relation between blood concentrations of free 25-hydroxyvitamin D with cardiovascular events in end-stage chronic kidney disease patients on hemodialysis, because this is unknown so far. We measured free vitamin D levels in 117 stable consecutive prevalent patients in September as a surrogate of vitamin D exposure during the past 6 months, and recorded the number of cardiovascular events during the previous 6 months defined as hospitalization due to heart failure, episodes of acute coronary syndrome, and stroke. Fourteen events occurred during the observation period. In patients without any cardiovascular events the free vitamin D levels were significantly higher as compared to those with cardiovascular events (patients without events: 5.68 [4.37–9.27] pg/mL; patients with events: 4.74 [3.46–5.37] pg/mL, p = 0.015). This finding remained stable after multiple regression analysis considering confounding factors such as age, time on dialysis, preexisting diabetes, hypertension, and coronary heart disease. In conclusion, our study shows that free vitamin D serum concentrations are independently associated with major cardiovascular events in chronic kidney disease patients on dialysis. |
| first_indexed | 2024-12-11T00:55:45Z |
| format | Article |
| id | doaj.art-d71a63ca8bcf4ad5badc007a039a83f4 |
| institution | Directory Open Access Journal |
| issn | 1420-4096 1423-0143 |
| language | English |
| last_indexed | 2024-12-11T00:55:45Z |
| publishDate | 2019-06-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Kidney & Blood Pressure Research |
| spelling | doaj.art-d71a63ca8bcf4ad5badc007a039a83f42022-12-22T01:26:30ZengKarger PublishersKidney & Blood Pressure Research1420-40961423-01432019-06-0144334435310.1159/000499878499878Free 25-Vitamin D Is Correlated with Cardiovascular Events in Prevalent Hemodialysis Patients but Not with Markers of Renal Mineral Bone DiseaseXin ChenYong-Ping LuTing LuoHong-Wei WuSu-Fen CaiMei TianLiang-Hong YinBernhard K. KrämerFan-Na LiuBerthold HocherSaban ElitokFree vitamin D is the biologically active form of vitamin D. Vitamin D deficiency is associated with cardiovascular disease, the most common cause of mortality in hemodialysis patients. The goal of our current study was to investigate the relation between blood concentrations of free 25-hydroxyvitamin D with cardiovascular events in end-stage chronic kidney disease patients on hemodialysis, because this is unknown so far. We measured free vitamin D levels in 117 stable consecutive prevalent patients in September as a surrogate of vitamin D exposure during the past 6 months, and recorded the number of cardiovascular events during the previous 6 months defined as hospitalization due to heart failure, episodes of acute coronary syndrome, and stroke. Fourteen events occurred during the observation period. In patients without any cardiovascular events the free vitamin D levels were significantly higher as compared to those with cardiovascular events (patients without events: 5.68 [4.37–9.27] pg/mL; patients with events: 4.74 [3.46–5.37] pg/mL, p = 0.015). This finding remained stable after multiple regression analysis considering confounding factors such as age, time on dialysis, preexisting diabetes, hypertension, and coronary heart disease. In conclusion, our study shows that free vitamin D serum concentrations are independently associated with major cardiovascular events in chronic kidney disease patients on dialysis.https://www.karger.com/Article/FullText/499878Free vitamin DCardiovascular diseaseHemodialysis patients25-Hydroxyvitamin D |
| spellingShingle | Xin Chen Yong-Ping Lu Ting Luo Hong-Wei Wu Su-Fen Cai Mei Tian Liang-Hong Yin Bernhard K. Krämer Fan-Na Liu Berthold Hocher Saban Elitok Free 25-Vitamin D Is Correlated with Cardiovascular Events in Prevalent Hemodialysis Patients but Not with Markers of Renal Mineral Bone Disease Kidney & Blood Pressure Research Free vitamin D Cardiovascular disease Hemodialysis patients 25-Hydroxyvitamin D |
| title | Free 25-Vitamin D Is Correlated with Cardiovascular Events in Prevalent Hemodialysis Patients but Not with Markers of Renal Mineral Bone Disease |
| title_full | Free 25-Vitamin D Is Correlated with Cardiovascular Events in Prevalent Hemodialysis Patients but Not with Markers of Renal Mineral Bone Disease |
| title_fullStr | Free 25-Vitamin D Is Correlated with Cardiovascular Events in Prevalent Hemodialysis Patients but Not with Markers of Renal Mineral Bone Disease |
| title_full_unstemmed | Free 25-Vitamin D Is Correlated with Cardiovascular Events in Prevalent Hemodialysis Patients but Not with Markers of Renal Mineral Bone Disease |
| title_short | Free 25-Vitamin D Is Correlated with Cardiovascular Events in Prevalent Hemodialysis Patients but Not with Markers of Renal Mineral Bone Disease |
| title_sort | free 25 vitamin d is correlated with cardiovascular events in prevalent hemodialysis patients but not with markers of renal mineral bone disease |
| topic | Free vitamin D Cardiovascular disease Hemodialysis patients 25-Hydroxyvitamin D |
| url | https://www.karger.com/Article/FullText/499878 |
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