The Extracellular Vesicle–Macrophage Regulatory Axis: A Novel Pathogenesis for Endometriosis
Endometriosis (EMs) is a common disease among women whose pathogenesis is still unclear, although there are various hypotheses. Recent studies have considered macrophages the key part of the immune system in developing EMs, inducing inflammation, the growth and invasion of the ectopic endometrium, a...
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MDPI AG
2023-09-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/13/9/1376 |
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| author | Xiaoxiao Gao Han Gao Wei Shao Jiaqi Wang Mingqing Li Songping Liu |
| author_facet | Xiaoxiao Gao Han Gao Wei Shao Jiaqi Wang Mingqing Li Songping Liu |
| author_sort | Xiaoxiao Gao |
| collection | DOAJ |
| description | Endometriosis (EMs) is a common disease among women whose pathogenesis is still unclear, although there are various hypotheses. Recent studies have considered macrophages the key part of the immune system in developing EMs, inducing inflammation, the growth and invasion of the ectopic endometrium, and angiogenesis. Extracellular vesicles (EVs) as novel intercellular vesicle traffic, can be secreted by many kinds of cells, including macrophages. By carrying long non-coding RNA (lncRNA), microRNA (miRNA), or other molecules, EVs can regulate the biological functions of macrophages in an autocrine and paracrine manner, including ectopic lesion growth, immune dysfunction, angiogenesis, and can further accelerate the progression of EMs. In this review, the interactions between macrophages and EVs for the pathogenesis of EMs are summarized. Notably, the regulatory pathways and molecular mechanisms of EVs secreted by macrophages during EMs are reviewed. |
| first_indexed | 2024-03-10T22:59:44Z |
| format | Article |
| id | doaj.art-d71af15cf57545949d33be7ad3326e6a |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T22:59:44Z |
| publishDate | 2023-09-01 |
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| series | Biomolecules |
| spelling | doaj.art-d71af15cf57545949d33be7ad3326e6a2023-11-19T09:46:08ZengMDPI AGBiomolecules2218-273X2023-09-01139137610.3390/biom13091376The Extracellular Vesicle–Macrophage Regulatory Axis: A Novel Pathogenesis for EndometriosisXiaoxiao Gao0Han Gao1Wei Shao2Jiaqi Wang3Mingqing Li4Songping Liu5Department of Obstetrics and Gynecology, Jinshan Hospital, Fudan University, Shanghai 201508, ChinaDepartment of Obstetrics and Gynecology, Jinshan Hospital, Fudan University, Shanghai 201508, ChinaDepartment of Obstetrics and Gynecology, Jinshan Hospital, Fudan University, Shanghai 201508, ChinaDepartment of Obstetrics and Gynecology, Jinshan Hospital, Fudan University, Shanghai 201508, ChinaLaboratory for Reproductive Immunology, Institute Obstetrics and Gynecology, Hospital of Obstetrics and Gynecology, Fudan University, Shanghai 200080, ChinaDepartment of Obstetrics and Gynecology, Jinshan Hospital, Fudan University, Shanghai 201508, ChinaEndometriosis (EMs) is a common disease among women whose pathogenesis is still unclear, although there are various hypotheses. Recent studies have considered macrophages the key part of the immune system in developing EMs, inducing inflammation, the growth and invasion of the ectopic endometrium, and angiogenesis. Extracellular vesicles (EVs) as novel intercellular vesicle traffic, can be secreted by many kinds of cells, including macrophages. By carrying long non-coding RNA (lncRNA), microRNA (miRNA), or other molecules, EVs can regulate the biological functions of macrophages in an autocrine and paracrine manner, including ectopic lesion growth, immune dysfunction, angiogenesis, and can further accelerate the progression of EMs. In this review, the interactions between macrophages and EVs for the pathogenesis of EMs are summarized. Notably, the regulatory pathways and molecular mechanisms of EVs secreted by macrophages during EMs are reviewed.https://www.mdpi.com/2218-273X/13/9/1376endometriosismacrophagesextracellular vesiclespathogenesislncRNAmiRNA |
| spellingShingle | Xiaoxiao Gao Han Gao Wei Shao Jiaqi Wang Mingqing Li Songping Liu The Extracellular Vesicle–Macrophage Regulatory Axis: A Novel Pathogenesis for Endometriosis Biomolecules endometriosis macrophages extracellular vesicles pathogenesis lncRNA miRNA |
| title | The Extracellular Vesicle–Macrophage Regulatory Axis: A Novel Pathogenesis for Endometriosis |
| title_full | The Extracellular Vesicle–Macrophage Regulatory Axis: A Novel Pathogenesis for Endometriosis |
| title_fullStr | The Extracellular Vesicle–Macrophage Regulatory Axis: A Novel Pathogenesis for Endometriosis |
| title_full_unstemmed | The Extracellular Vesicle–Macrophage Regulatory Axis: A Novel Pathogenesis for Endometriosis |
| title_short | The Extracellular Vesicle–Macrophage Regulatory Axis: A Novel Pathogenesis for Endometriosis |
| title_sort | extracellular vesicle macrophage regulatory axis a novel pathogenesis for endometriosis |
| topic | endometriosis macrophages extracellular vesicles pathogenesis lncRNA miRNA |
| url | https://www.mdpi.com/2218-273X/13/9/1376 |
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