Cholinergic modulation of narcoleptic attacks in double orexin receptor knockout mice.

Cholinergic modulation of narcoleptic attacks in double orexin receptor knockout mice.

To investigate how cholinergic systems regulate aspects of the sleep disorder narcolepsy, we video-monitored mice lacking both orexin (hypocretin) receptors (double knockout; DKO mice) while pharmacologically altering cholinergic transmission. Spontaneous behavioral arrests in DKO mice were highly s...

Full description

Bibliographic Details
Main Authors: Mike Kalogiannis, Emily Hsu, Jon T Willie, Richard M Chemelli, Yaz Y Kisanuki, Masashi Yanagisawa, Christopher S Leonard
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-04-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3076437?pdf=render

Internet

http://europepmc.org/articles/PMC3076437?pdf=render

Similar Items