Estimation of absorbed doses in patients’ organs from the released radionuclide-label during radionuclide therapy with <sup>225</sup>Ac

Today, the treatment of cancer with the use of radiopharmaceuticals is a developing method all over the world. The preparation of the radiopharmaceuticals and its quality control prior to its administration to the patient is one of the important elements of nuclear medicine procedures. The instabili...

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Main Authors: A. E. Petrova, L. A. Chipiga, A. V. Vodovatov, A. A. Stanzhevsky, D. N. Maystrenko, A. A. Lumpov, A. B. Sinyukhin, I. V. Boykov, T. E. Rameshvili
Format: Article
Language:English
Published: Saint-Petersburg Research Institute of Radiation Hygiene after Professor P.V. Ramzaev 2022-04-01
Series:Радиационная гигиена
Subjects:
Online Access:https://www.radhyg.ru/jour/article/view/859
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author A. E. Petrova
L. A. Chipiga
A. V. Vodovatov
A. A. Stanzhevsky
D. N. Maystrenko
A. A. Lumpov
A. B. Sinyukhin
I. V. Boykov
T. E. Rameshvili
author_facet A. E. Petrova
L. A. Chipiga
A. V. Vodovatov
A. A. Stanzhevsky
D. N. Maystrenko
A. A. Lumpov
A. B. Sinyukhin
I. V. Boykov
T. E. Rameshvili
author_sort A. E. Petrova
collection DOAJ
description Today, the treatment of cancer with the use of radiopharmaceuticals is a developing method all over the world. The preparation of the radiopharmaceuticals and its quality control prior to its administration to the patient is one of the important elements of nuclear medicine procedures. The instability of the compound can lead to a change in the distribution of the radionuclide in the patient’s body, a decrease in the effectiveness of treatment, as well as to unjustified irradiation of healthy organs and tissues. The aim of this work was to estimate the absorbed doses in human organs and tissues during radionuclide therapy using 225Ac for the case of the 225Ac release. The absorbed doses were calculated for the model presented in ICRP Publication 141 for healthy people. This model consists of 18 cameras (blood, cortical volume, cortical surface, cortical red bone marrow, trabecular volume, trabecular surface, trabecular red bone marrow, kidneys (two chambers), bladder, liver (two chambers), gonads, contents of the small intestine, contents of the upper large intestine, soft tissues. Time-integrated activities were calculated using the specialized software SAAM II v2.3. The calculation of absorbed doses was performed using the IDAC-Dose 2.1 software. The highest absorbed doses were obtained for liver, testes, ovaries and red bone marrow, which leads to an increase in doses in these organs in comparison with doses from 225Ac-PSMA up to a factor of two. A change in the biodistribution of 225Ac in a patient’s body, associated with the release of a radionuclide from the radiopharmaceuticals, can lead to an increase in doses in healthy radiosensitive organs and tissues, as well as to a decrease in the effectiveness of treatment.
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spelling doaj.art-d71c2d092bad4569b84dec387ebd27592025-03-05T14:03:19ZengSaint-Petersburg Research Institute of Radiation Hygiene after Professor P.V. RamzaevРадиационная гигиена1998-426X2022-04-0115112013110.21514/1998-426X-2022-15-1-120-131743Estimation of absorbed doses in patients’ organs from the released radionuclide-label during radionuclide therapy with <sup>225</sup>AcA. E. Petrova0L. A. Chipiga1A. V. Vodovatov2A. A. Stanzhevsky3D. N. Maystrenko4A. A. Lumpov5A. B. Sinyukhin6I. V. Boykov7T. E. Rameshvili8Saint-Petersburg Research Institute of Radiation Hygiene after Professor P. V. Ramzaev, Federal Service for Surveillance on Consumer Rights Protection and Human Well-BeingSaint-Petersburg Research Institute of Radiation Hygiene after Professor P. V. Ramzaev, Federal Service for Surveillance on Consumer Rights Protection and Human Well-Being; A. M. Granov Russian Scientific Center of Radiology and Surgical Technologies of the Ministry of Health of the Russian Federation; Almazov National Medical Research Centre of the Ministry of Health of the Russian FederationSaint-Petersburg Research Institute of Radiation Hygiene after Professor P.V. Ramzaev, Federal Service for Surveillance on Consumer Rights Protection and Human Well-Being; Saint-Petersburg State Pediatric Medical UniversityA. M. Granov Russian Scientific Center of Radiology and Surgical Technologies of the Ministry of Health of the Russian FederationA. M. Granov Russian Scientific Center of Radiology and Surgical Technologies of the Ministry of Health of the Russian FederationKhlopin Radium InstituteIsotopeMilitary Medical Academy named S. M. Kirov of the Ministry of Defense of the Russian FederationMilitary Medical Academy named S. M. Kirov of the Ministry of Defense of the Russian FederationToday, the treatment of cancer with the use of radiopharmaceuticals is a developing method all over the world. The preparation of the radiopharmaceuticals and its quality control prior to its administration to the patient is one of the important elements of nuclear medicine procedures. The instability of the compound can lead to a change in the distribution of the radionuclide in the patient’s body, a decrease in the effectiveness of treatment, as well as to unjustified irradiation of healthy organs and tissues. The aim of this work was to estimate the absorbed doses in human organs and tissues during radionuclide therapy using 225Ac for the case of the 225Ac release. The absorbed doses were calculated for the model presented in ICRP Publication 141 for healthy people. This model consists of 18 cameras (blood, cortical volume, cortical surface, cortical red bone marrow, trabecular volume, trabecular surface, trabecular red bone marrow, kidneys (two chambers), bladder, liver (two chambers), gonads, contents of the small intestine, contents of the upper large intestine, soft tissues. Time-integrated activities were calculated using the specialized software SAAM II v2.3. The calculation of absorbed doses was performed using the IDAC-Dose 2.1 software. The highest absorbed doses were obtained for liver, testes, ovaries and red bone marrow, which leads to an increase in doses in these organs in comparison with doses from 225Ac-PSMA up to a factor of two. A change in the biodistribution of 225Ac in a patient’s body, associated with the release of a radionuclide from the radiopharmaceuticals, can lead to an increase in doses in healthy radiosensitive organs and tissues, as well as to a decrease in the effectiveness of treatment.https://www.radhyg.ru/jour/article/view/859<sup>225</sup>аcradionuclide therapyradiopharmaceuticalsabsorbed doses in organs
spellingShingle A. E. Petrova
L. A. Chipiga
A. V. Vodovatov
A. A. Stanzhevsky
D. N. Maystrenko
A. A. Lumpov
A. B. Sinyukhin
I. V. Boykov
T. E. Rameshvili
Estimation of absorbed doses in patients’ organs from the released radionuclide-label during radionuclide therapy with <sup>225</sup>Ac
Радиационная гигиена
<sup>225</sup>аc
radionuclide therapy
radiopharmaceuticals
absorbed doses in organs
title Estimation of absorbed doses in patients’ organs from the released radionuclide-label during radionuclide therapy with <sup>225</sup>Ac
title_full Estimation of absorbed doses in patients’ organs from the released radionuclide-label during radionuclide therapy with <sup>225</sup>Ac
title_fullStr Estimation of absorbed doses in patients’ organs from the released radionuclide-label during radionuclide therapy with <sup>225</sup>Ac
title_full_unstemmed Estimation of absorbed doses in patients’ organs from the released radionuclide-label during radionuclide therapy with <sup>225</sup>Ac
title_short Estimation of absorbed doses in patients’ organs from the released radionuclide-label during radionuclide therapy with <sup>225</sup>Ac
title_sort estimation of absorbed doses in patients organs from the released radionuclide label during radionuclide therapy with sup 225 sup ac
topic <sup>225</sup>аc
radionuclide therapy
radiopharmaceuticals
absorbed doses in organs
url https://www.radhyg.ru/jour/article/view/859
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