Manipulation of the follicular phase: Uterodomes and pregnancy - is there a correlation?
<p>Abstract</p> <p>Background</p> <p>Manipulation of the follicular phase uterine epithelium in women undergoing infertility treatment, has not generally shown differing morphological effects on uterine epithelial characteristics using Scanning Electron Microscopy (SEM)...
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| Format: | Article |
| Language: | English |
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BMC
2001-07-01
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| Series: | BMC Pregnancy and Childbirth |
| Online Access: | http://www.biomedcentral.com/1471-2393/1/2 |
| _version_ | 1818068301331300352 |
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| author | Terry Vera Gayer Nalini Adams Susan M Murphy Christopher R |
| author_facet | Terry Vera Gayer Nalini Adams Susan M Murphy Christopher R |
| author_sort | Terry Vera |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Manipulation of the follicular phase uterine epithelium in women undergoing infertility treatment, has not generally shown differing morphological effects on uterine epithelial characteristics using Scanning Electron Microscopy (SEM) and resultant pregnancy rates have remained suboptimal utilising these manipulations. The present study observed manipulation of the proliferative epithelium, with either 7 or 14 days of sequential oestrogen (E) therapy followed by progesterone (P) and assessed the appearance of pinopods (now called uterodomes) for their usefulness as potential implantation markers in seven women who subsequently became pregnant. Three endometrial biopsies per patient were taken during consecutive cycles: day 19 of a natural cycle - (group 1), days 11/12 of a second cycle after 7 days E then P - (group 2), and days 19/22 of a third cycle after 14 days E then P - (group 3). Embryo transfer (ET) was performed in a subsequent long treatment cycle (as per Group 3).</p> <p>Results</p> <p>Seven pregnancies resulted in seven viable births including one twins and one miscarriage. Analysis of the individual regimes showed 5 days of P treatment to have a higher correlation for uterodomes in all 3 cycles observed individually. It was also observed that all 7 women demonstrated the appearance of uterodomes in at least one of their cycles.</p> <p>Conclusions</p> <p>We conclude that manipulation of the follicular phase by shortening the period of E exposure to 7 days, does not compromise uterine epithelial morphology and we add weight to the conclusion that uterodomes indicate a receptive endometrium for implantation.</p> |
| first_indexed | 2024-12-10T15:37:24Z |
| format | Article |
| id | doaj.art-d71c546d887944f38a5ca6f927f75012 |
| institution | Directory Open Access Journal |
| issn | 1471-2393 |
| language | English |
| last_indexed | 2024-12-10T15:37:24Z |
| publishDate | 2001-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pregnancy and Childbirth |
| spelling | doaj.art-d71c546d887944f38a5ca6f927f750122022-12-22T01:43:13ZengBMCBMC Pregnancy and Childbirth1471-23932001-07-0111210.1186/1471-2393-1-2Manipulation of the follicular phase: Uterodomes and pregnancy - is there a correlation?Terry VeraGayer NaliniAdams Susan MMurphy Christopher R<p>Abstract</p> <p>Background</p> <p>Manipulation of the follicular phase uterine epithelium in women undergoing infertility treatment, has not generally shown differing morphological effects on uterine epithelial characteristics using Scanning Electron Microscopy (SEM) and resultant pregnancy rates have remained suboptimal utilising these manipulations. The present study observed manipulation of the proliferative epithelium, with either 7 or 14 days of sequential oestrogen (E) therapy followed by progesterone (P) and assessed the appearance of pinopods (now called uterodomes) for their usefulness as potential implantation markers in seven women who subsequently became pregnant. Three endometrial biopsies per patient were taken during consecutive cycles: day 19 of a natural cycle - (group 1), days 11/12 of a second cycle after 7 days E then P - (group 2), and days 19/22 of a third cycle after 14 days E then P - (group 3). Embryo transfer (ET) was performed in a subsequent long treatment cycle (as per Group 3).</p> <p>Results</p> <p>Seven pregnancies resulted in seven viable births including one twins and one miscarriage. Analysis of the individual regimes showed 5 days of P treatment to have a higher correlation for uterodomes in all 3 cycles observed individually. It was also observed that all 7 women demonstrated the appearance of uterodomes in at least one of their cycles.</p> <p>Conclusions</p> <p>We conclude that manipulation of the follicular phase by shortening the period of E exposure to 7 days, does not compromise uterine epithelial morphology and we add weight to the conclusion that uterodomes indicate a receptive endometrium for implantation.</p>http://www.biomedcentral.com/1471-2393/1/2 |
| spellingShingle | Terry Vera Gayer Nalini Adams Susan M Murphy Christopher R Manipulation of the follicular phase: Uterodomes and pregnancy - is there a correlation? BMC Pregnancy and Childbirth |
| title | Manipulation of the follicular phase: Uterodomes and pregnancy - is there a correlation? |
| title_full | Manipulation of the follicular phase: Uterodomes and pregnancy - is there a correlation? |
| title_fullStr | Manipulation of the follicular phase: Uterodomes and pregnancy - is there a correlation? |
| title_full_unstemmed | Manipulation of the follicular phase: Uterodomes and pregnancy - is there a correlation? |
| title_short | Manipulation of the follicular phase: Uterodomes and pregnancy - is there a correlation? |
| title_sort | manipulation of the follicular phase uterodomes and pregnancy is there a correlation |
| url | http://www.biomedcentral.com/1471-2393/1/2 |
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