Haematogenous abdominal wall metastasis of differentiated, alpha-fetoprotein-negative hepatocellular carcinoma after previous antiandrogen therapy within a site of lipoma manifestation since childhood
<p>Abstract</p> <p>Background</p> <p>Cases with subcutaneous metastasis of differentiated hepatocellular carcinoma to the abdominal wall without prior seeding as a consequence of local interventions with a negative or normal alpha-fetoprotein level in the serum are extr...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2012-05-01
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| Series: | World Journal of Surgical Oncology |
| Subjects: | |
| Online Access: | http://www.wjso.com/content/10/1/98 |
| _version_ | 1818835848007778304 |
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| author | Zachau L Zeckey C Schlue J Sander J Meyer-Heithuis C Winkler M Klempnauer J Schrem H |
| author_facet | Zachau L Zeckey C Schlue J Sander J Meyer-Heithuis C Winkler M Klempnauer J Schrem H |
| author_sort | Zachau L |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Cases with subcutaneous metastasis of differentiated hepatocellular carcinoma to the abdominal wall without prior seeding as a consequence of local interventions with a negative or normal alpha-fetoprotein level in the serum are extremely rare.</p> <p>Case report</p> <p>This is the first report of a case with AFP-negative, differentiated hepatocellular carcinoma metastasis to the abdominal wall within a pre-existing subcutaneous lipoma since childhood after antiandrogen therapy with leuprorelin and buserelin acetate for prostate cancer without seeding.</p> <p>Methods</p> <p>Clinical features including histology, immunohistochemistry, clinical course and surgical approach are presented.</p> <p>Results</p> <p>Histological examination revealed a hepatocellular carcinoma with a trabecular and pseudoglandular growth pattern with moderately atypical hepatocytes with multifocal bile formation within a lipoma. The postoperative course of abdominal wall reconstruction with a monocryl-prolene mesh and a local flap after potentially curative resection was uncomplicated.</p> <p>Discussion and conclusion</p> <p>It may be that previous antiandrogen treatment for prostate carcinoma contributed to the fact that our patient developed alpha-fetoprotein-negative and androgen receptor-negative subcutaneous abdominal wall metastasis within a pre-existing lipoma since childhood.</p> |
| first_indexed | 2024-12-19T02:57:13Z |
| format | Article |
| id | doaj.art-d71c84cc0bda4740919b9f813e5c3148 |
| institution | Directory Open Access Journal |
| issn | 1477-7819 |
| language | English |
| last_indexed | 2024-12-19T02:57:13Z |
| publishDate | 2012-05-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj.art-d71c84cc0bda4740919b9f813e5c31482022-12-21T20:38:19ZengBMCWorld Journal of Surgical Oncology1477-78192012-05-011019810.1186/1477-7819-10-98Haematogenous abdominal wall metastasis of differentiated, alpha-fetoprotein-negative hepatocellular carcinoma after previous antiandrogen therapy within a site of lipoma manifestation since childhoodZachau LZeckey CSchlue JSander JMeyer-Heithuis CWinkler MKlempnauer JSchrem H<p>Abstract</p> <p>Background</p> <p>Cases with subcutaneous metastasis of differentiated hepatocellular carcinoma to the abdominal wall without prior seeding as a consequence of local interventions with a negative or normal alpha-fetoprotein level in the serum are extremely rare.</p> <p>Case report</p> <p>This is the first report of a case with AFP-negative, differentiated hepatocellular carcinoma metastasis to the abdominal wall within a pre-existing subcutaneous lipoma since childhood after antiandrogen therapy with leuprorelin and buserelin acetate for prostate cancer without seeding.</p> <p>Methods</p> <p>Clinical features including histology, immunohistochemistry, clinical course and surgical approach are presented.</p> <p>Results</p> <p>Histological examination revealed a hepatocellular carcinoma with a trabecular and pseudoglandular growth pattern with moderately atypical hepatocytes with multifocal bile formation within a lipoma. The postoperative course of abdominal wall reconstruction with a monocryl-prolene mesh and a local flap after potentially curative resection was uncomplicated.</p> <p>Discussion and conclusion</p> <p>It may be that previous antiandrogen treatment for prostate carcinoma contributed to the fact that our patient developed alpha-fetoprotein-negative and androgen receptor-negative subcutaneous abdominal wall metastasis within a pre-existing lipoma since childhood.</p>http://www.wjso.com/content/10/1/98Hepatocellular carcinomaCutaneous metastasisAntiandrogen therapy |
| spellingShingle | Zachau L Zeckey C Schlue J Sander J Meyer-Heithuis C Winkler M Klempnauer J Schrem H Haematogenous abdominal wall metastasis of differentiated, alpha-fetoprotein-negative hepatocellular carcinoma after previous antiandrogen therapy within a site of lipoma manifestation since childhood World Journal of Surgical Oncology Hepatocellular carcinoma Cutaneous metastasis Antiandrogen therapy |
| title | Haematogenous abdominal wall metastasis of differentiated, alpha-fetoprotein-negative hepatocellular carcinoma after previous antiandrogen therapy within a site of lipoma manifestation since childhood |
| title_full | Haematogenous abdominal wall metastasis of differentiated, alpha-fetoprotein-negative hepatocellular carcinoma after previous antiandrogen therapy within a site of lipoma manifestation since childhood |
| title_fullStr | Haematogenous abdominal wall metastasis of differentiated, alpha-fetoprotein-negative hepatocellular carcinoma after previous antiandrogen therapy within a site of lipoma manifestation since childhood |
| title_full_unstemmed | Haematogenous abdominal wall metastasis of differentiated, alpha-fetoprotein-negative hepatocellular carcinoma after previous antiandrogen therapy within a site of lipoma manifestation since childhood |
| title_short | Haematogenous abdominal wall metastasis of differentiated, alpha-fetoprotein-negative hepatocellular carcinoma after previous antiandrogen therapy within a site of lipoma manifestation since childhood |
| title_sort | haematogenous abdominal wall metastasis of differentiated alpha fetoprotein negative hepatocellular carcinoma after previous antiandrogen therapy within a site of lipoma manifestation since childhood |
| topic | Hepatocellular carcinoma Cutaneous metastasis Antiandrogen therapy |
| url | http://www.wjso.com/content/10/1/98 |
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