Questions and Answers Related to the Prebiotic Production of Oligonucleotide Sequences from 3′,5′ Cyclic Nucleotide Precursors

Template-free nonenzymatic polymerization of 3′,5′ cyclic nucleotides is an emerging topic of the origin of life research. In the last ten years, a number of papers have been published addressing various aspects of this process. These works evoked a vivid discussion among scientists working in the f...

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Bibliographic Details
Main Authors: Judit E. Šponer, Jiří Šponer, Aleš Kovařík, Ondrej Šedo, Zbyněk Zdráhal, Giovanna Costanzo, Ernesto Di Mauro
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Life
Subjects:
Online Access:https://www.mdpi.com/2075-1729/11/8/800
Description
Summary:Template-free nonenzymatic polymerization of 3′,5′ cyclic nucleotides is an emerging topic of the origin of life research. In the last ten years, a number of papers have been published addressing various aspects of this process. These works evoked a vivid discussion among scientists working in the field of prebiotic chemistry. The aim of the current review is to answer the most frequently raised questions related to the detection and characterization of oligomeric products as well as to the geological context of this chemistry.
ISSN:2075-1729