Streptoglycerides E–H, Unsaturated Polyketides from the Marine-Derived Bacterium <i>Streptomyces</i> <i>specialis</i> and Their Anti-Inflammatory Activity
Four new streptoglycerides E–H (<b>1</b>–<b>4</b>), with a rare 6/5/5/-membered ring system, were isolated from a marine-derived actinomycete <i>Streptomyces specialis</i>. The structures of <b>1</b>–<b>4</b> were elucidated by detailed ana...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/20/1/44 |
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| author | Hee Jae Shin Chang-Su Heo Cao Van Anh Yeo Dae Yoon Jong Soon Kang |
| author_facet | Hee Jae Shin Chang-Su Heo Cao Van Anh Yeo Dae Yoon Jong Soon Kang |
| author_sort | Hee Jae Shin |
| collection | DOAJ |
| description | Four new streptoglycerides E–H (<b>1</b>–<b>4</b>), with a rare 6/5/5/-membered ring system, were isolated from a marine-derived actinomycete <i>Streptomyces specialis</i>. The structures of <b>1</b>–<b>4</b> were elucidated by detailed analysis of HRESIMS, 1D and 2D NMR data and ECD spectra as well as comparison of their spectroscopic data with those reported in literature. Compounds <b>1</b>–<b>4</b> showed significant anti-inflammatory activity by inhibiting lipopolysaccharide (LPS)-induced nitric oxide (NO) production in Raw 264.7 cells with IC<sub>50</sub> values ranging from 3.5 to 10.9 µM. Especially, <b>2</b> suppressed mRNA expression levels of iNOS and IL-6 without cytotoxicity. |
| first_indexed | 2024-03-10T01:05:53Z |
| format | Article |
| id | doaj.art-d71d2e01c9e8405fae892705e1959796 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-03-10T01:05:53Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-d71d2e01c9e8405fae892705e19597962023-11-23T14:27:54ZengMDPI AGMarine Drugs1660-33972022-01-012014410.3390/md20010044Streptoglycerides E–H, Unsaturated Polyketides from the Marine-Derived Bacterium <i>Streptomyces</i> <i>specialis</i> and Their Anti-Inflammatory ActivityHee Jae Shin0Chang-Su Heo1Cao Van Anh2Yeo Dae Yoon3Jong Soon Kang4Marine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology, 385 Haeyang-ro, Yeongdo-gu, Busan 49111, KoreaMarine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology, 385 Haeyang-ro, Yeongdo-gu, Busan 49111, KoreaMarine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology, 385 Haeyang-ro, Yeongdo-gu, Busan 49111, KoreaLaboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanjiro, Cheongju 28116, KoreaLaboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanjiro, Cheongju 28116, KoreaFour new streptoglycerides E–H (<b>1</b>–<b>4</b>), with a rare 6/5/5/-membered ring system, were isolated from a marine-derived actinomycete <i>Streptomyces specialis</i>. The structures of <b>1</b>–<b>4</b> were elucidated by detailed analysis of HRESIMS, 1D and 2D NMR data and ECD spectra as well as comparison of their spectroscopic data with those reported in literature. Compounds <b>1</b>–<b>4</b> showed significant anti-inflammatory activity by inhibiting lipopolysaccharide (LPS)-induced nitric oxide (NO) production in Raw 264.7 cells with IC<sub>50</sub> values ranging from 3.5 to 10.9 µM. Especially, <b>2</b> suppressed mRNA expression levels of iNOS and IL-6 without cytotoxicity.https://www.mdpi.com/1660-3397/20/1/44marine-derived bacterium<i>Streptomyces specialis</i>streptoglyceridesanti-inflammatory |
| spellingShingle | Hee Jae Shin Chang-Su Heo Cao Van Anh Yeo Dae Yoon Jong Soon Kang Streptoglycerides E–H, Unsaturated Polyketides from the Marine-Derived Bacterium <i>Streptomyces</i> <i>specialis</i> and Their Anti-Inflammatory Activity Marine Drugs marine-derived bacterium <i>Streptomyces specialis</i> streptoglycerides anti-inflammatory |
| title | Streptoglycerides E–H, Unsaturated Polyketides from the Marine-Derived Bacterium <i>Streptomyces</i> <i>specialis</i> and Their Anti-Inflammatory Activity |
| title_full | Streptoglycerides E–H, Unsaturated Polyketides from the Marine-Derived Bacterium <i>Streptomyces</i> <i>specialis</i> and Their Anti-Inflammatory Activity |
| title_fullStr | Streptoglycerides E–H, Unsaturated Polyketides from the Marine-Derived Bacterium <i>Streptomyces</i> <i>specialis</i> and Their Anti-Inflammatory Activity |
| title_full_unstemmed | Streptoglycerides E–H, Unsaturated Polyketides from the Marine-Derived Bacterium <i>Streptomyces</i> <i>specialis</i> and Their Anti-Inflammatory Activity |
| title_short | Streptoglycerides E–H, Unsaturated Polyketides from the Marine-Derived Bacterium <i>Streptomyces</i> <i>specialis</i> and Their Anti-Inflammatory Activity |
| title_sort | streptoglycerides e h unsaturated polyketides from the marine derived bacterium i streptomyces i i specialis i and their anti inflammatory activity |
| topic | marine-derived bacterium <i>Streptomyces specialis</i> streptoglycerides anti-inflammatory |
| url | https://www.mdpi.com/1660-3397/20/1/44 |
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