NDSP 12: Atherogenic index of plasma as a useful marker of cardiovascular disease risk among Pakistani individuals; a study from the second National Diabetes Survey of Pakistan (NDSP) 2016–2017
Aim: To investigate the reliability of atherogenic index of plasma (AIP) as a marker of cardiovascular disease risk and its correlation with CVD risk factors. Methodology: It is a sub-study of the second National Diabetes Survey of Pakistan (NDSP) 2016–2017, an epidemiological survey including both...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Clinical Epidemiology and Global Health |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213398422002457 |
| _version_ | 1811172058727448576 |
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| author | Asher Fawwad Yasir Mahmood Saima Askari Anum Butt Abdul Basit Mujeeb Ur Rehman Abro Khawaja Ishfaq Ahmed Khurshid Ahmed Sobia Sabir Ali Ahmed Bilal Anam Butt Bikha Ram Devrajani Ijaz Hayder Yasir Humayun Rabia Irshad Riasat Ali Khan Asima Khan Aamir Akram Khowaja Raheela Khowaja Qazi Masroor Maqsood Mehmood Hassan Moin Nida Mustafa Wasif Noor Huma Qureshi Ibrar Rafique Tahir Rasool Rubina Sabir M. Arif N. Saqib Pir Alam Said Abrar Shaikh Bilal Bin Younus Bilal Tahir Salma Tanveer Jamal Zafar |
| author_facet | Asher Fawwad Yasir Mahmood Saima Askari Anum Butt Abdul Basit Mujeeb Ur Rehman Abro Khawaja Ishfaq Ahmed Khurshid Ahmed Sobia Sabir Ali Ahmed Bilal Anam Butt Bikha Ram Devrajani Ijaz Hayder Yasir Humayun Rabia Irshad Riasat Ali Khan Asima Khan Aamir Akram Khowaja Raheela Khowaja Qazi Masroor Maqsood Mehmood Hassan Moin Nida Mustafa Wasif Noor Huma Qureshi Ibrar Rafique Tahir Rasool Rubina Sabir M. Arif N. Saqib Pir Alam Said Abrar Shaikh Bilal Bin Younus Bilal Tahir Salma Tanveer Jamal Zafar |
| author_sort | Asher Fawwad |
| collection | DOAJ |
| description | Aim: To investigate the reliability of atherogenic index of plasma (AIP) as a marker of cardiovascular disease risk and its correlation with CVD risk factors. Methodology: It is a sub-study of the second National Diabetes Survey of Pakistan (NDSP) 2016–2017, an epidemiological survey including both genders with >20 years of age in all four provinces of Pakistan. Out of 213 clusters, twenty-seven clusters were selected and households were identified from each cluster. Selected members of every 10th household were counseled for a visit to the campsite after observing an overnight fast. Standardized techniques were used for measuring height, weight, BMI, waist circumference, and blood pressure. Biochemical parameters including oral glucose tolerance test, lipid profile, and various lipid-derived parameter/ratios were also analyzed via standardized methods. Results: A total of 7351 individuals were selected for this sub-analysis after fulfilling the inclusion criteria. Mean AIP score was calculated as 0.38 ± 0.31 with statistically significant difference among all groups (p < 0.0001), and according to the AIP risk categorization, a majority of 6996 individuals (95.2%) fell in the high-risk category of developing CVD, whereas 258 (3.5%) were in moderate and only 97 (1.3%) individuals were found in the low-risk category. Multiple logistic regression analyses showed male gender and diabetes as risk factors for developing CVD based on the AIP score. Furthermore, various lipid-derived parameters LDL-C and HDL-C, TG and HDL-C, lipoprotein combined index (LCI) were shown a strong correlation with AIP. Conclusion: The significant association between AIP and CVD risk factors exists and high levels of AIP in Pakistani population may be an alarming sign in developing cardiovascular disease. |
| first_indexed | 2024-04-10T17:24:13Z |
| format | Article |
| id | doaj.art-d72034e4a7ea4d04ae3d5b1fe6daca36 |
| institution | Directory Open Access Journal |
| issn | 2213-3984 |
| language | English |
| last_indexed | 2024-04-10T17:24:13Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Clinical Epidemiology and Global Health |
| spelling | doaj.art-d72034e4a7ea4d04ae3d5b1fe6daca362023-02-05T04:16:13ZengElsevierClinical Epidemiology and Global Health2213-39842023-01-0119101202NDSP 12: Atherogenic index of plasma as a useful marker of cardiovascular disease risk among Pakistani individuals; a study from the second National Diabetes Survey of Pakistan (NDSP) 2016–2017Asher Fawwad0Yasir Mahmood1Saima Askari2Anum Butt3Abdul Basit4Mujeeb Ur Rehman Abro5Khawaja Ishfaq Ahmed6Khurshid Ahmed7Sobia Sabir Ali8Ahmed Bilal9Anam Butt10Bikha Ram Devrajani11Ijaz Hayder12Yasir Humayun13Rabia Irshad14Riasat Ali Khan15Asima Khan16Aamir Akram Khowaja17Raheela Khowaja18Qazi Masroor19Maqsood Mehmood20Hassan Moin21Nida Mustafa22Wasif Noor23Huma Qureshi24Ibrar Rafique25Tahir Rasool26Rubina Sabir27M. Arif N. Saqib28Pir Alam Said29Abrar Shaikh30Bilal Bin Younus31Bilal Tahir32Salma Tanveer33Jamal Zafar34Baqai Institute of Diabetology and Endocrinology, Baqai Medical University, Karachi, Pakistan; Corresponding author. Biochemistry Department, Baqai Medical University, Baqai Institute of Diabetology and Endocrinology, Baqai Medical University, Plot No. 1-2, II-B, Nazimabad No2, Karachi, 74600, Pakistan.Baqai Institute of Diabetology and Endocrinology, Baqai Medical University, Karachi, PakistanBaqai Institute of Diabetology and Endocrinology, Baqai Medical University, Karachi, PakistanBaqai Institute of Diabetology and Endocrinology, Baqai Medical University, Karachi, PakistanBaqai Institute of Diabetology and Endocrinology, Baqai Medical University, Karachi, PakistanChandka Medical College, Shaheed Mohtarma Benazir Bhutto Medical University, Larkana, Sindh, PakistanPakistan Institute of Medical Sciences, Islamabad, Punjab, PakistanZahid Medical Centre, Hub, Baluchistan, PakistanDepartment of Diabetes and Endocrinology, Lady Reading Hospital, Peshawar, Khyber Pakhtunkhwa, PakistanMedical Department Faisalabad Medical College, Faisalabad, Punjab, PakistanBaqai Institute of Diabetology and Endocrinology, Baqai Medical University, Karachi, Sindh, PakistanDepartment of Medicine and Director Sindh Institute of Endocrinology and Diabetes, Liaquat University of Medical and Health Sciences, Jamshoro, Sindh, PakistanPakistan Health Research Council, Karachi, Sindh, PakistanDHO Office, Mansehra, Khyber Pakhtunkhwa, PakistanPakistan Health Research Council, Karachi, Sindh, PakistanCanada Medical Group Hospital, Defence, Karachi, Sindh, PakistanDiabetes Department, Sindh Government Hospital, New Karachi, Karachi, Sindh, PakistanSindh Government Qatar Hospital, Karachi, Sindh, PakistanBaqai Institute of Diabetology and Endocrinology, Baqai Medical University, Karachi, Sindh, PakistanMedicine and Head of Department, Quaid-e-Azam Medical College, Bahawalpur, Punjab, PakistanDepartment, Fatma tu Zahra Hospital, Gujranwala, Punjab, PakistanBaqai Institute of Diabetology and Endocrinology, Baqai Medical University, Karachi, Sindh, PakistanBaqai Institute of Diabetology and Endocrinology, Baqai Medical University, Karachi, Sindh, PakistanDHQ, Sawabi, Khyber Pakhtunkhwa, PakistanPakistan Health Research Council, Karachi, Sindh, PakistanPakistan Health Research Council, Karachi, Sindh, PakistanAkhuwat Health Services Diabetes Centre, Lahore, Punjab, PakistanBaqai Institute of Diabetology and Endocrinology, Baqai Medical University, Karachi, Sindh, PakistanPakistan Health Research Council, Karachi, Sindh, PakistanDHQ, Sawabi, Khyber Pakhtunkhwa, PakistanDepartment of Medicine, Ghulam Muhammad Mahar Medical College, Sukkur, Sindh, PakistanSakeena Institute of Diabetes & Endocrine Research, Lahore, Punjab, PakistanBaqai Institute of Diabetology and Endocrinology, Baqai Medical University, Karachi, Sindh, PakistanDiabetes and Endocrinology, Nishter Medical University, Multan, Punjab, PakistanPakistan Institute of Medical Sciences, Islamabad, Punjab, PakistanAim: To investigate the reliability of atherogenic index of plasma (AIP) as a marker of cardiovascular disease risk and its correlation with CVD risk factors. Methodology: It is a sub-study of the second National Diabetes Survey of Pakistan (NDSP) 2016–2017, an epidemiological survey including both genders with >20 years of age in all four provinces of Pakistan. Out of 213 clusters, twenty-seven clusters were selected and households were identified from each cluster. Selected members of every 10th household were counseled for a visit to the campsite after observing an overnight fast. Standardized techniques were used for measuring height, weight, BMI, waist circumference, and blood pressure. Biochemical parameters including oral glucose tolerance test, lipid profile, and various lipid-derived parameter/ratios were also analyzed via standardized methods. Results: A total of 7351 individuals were selected for this sub-analysis after fulfilling the inclusion criteria. Mean AIP score was calculated as 0.38 ± 0.31 with statistically significant difference among all groups (p < 0.0001), and according to the AIP risk categorization, a majority of 6996 individuals (95.2%) fell in the high-risk category of developing CVD, whereas 258 (3.5%) were in moderate and only 97 (1.3%) individuals were found in the low-risk category. Multiple logistic regression analyses showed male gender and diabetes as risk factors for developing CVD based on the AIP score. Furthermore, various lipid-derived parameters LDL-C and HDL-C, TG and HDL-C, lipoprotein combined index (LCI) were shown a strong correlation with AIP. Conclusion: The significant association between AIP and CVD risk factors exists and high levels of AIP in Pakistani population may be an alarming sign in developing cardiovascular disease.http://www.sciencedirect.com/science/article/pii/S2213398422002457Atherogenic index of plasmaCardiovascular riskDyslipidemiaNational diabetes survey of Pakistan |
| spellingShingle | Asher Fawwad Yasir Mahmood Saima Askari Anum Butt Abdul Basit Mujeeb Ur Rehman Abro Khawaja Ishfaq Ahmed Khurshid Ahmed Sobia Sabir Ali Ahmed Bilal Anam Butt Bikha Ram Devrajani Ijaz Hayder Yasir Humayun Rabia Irshad Riasat Ali Khan Asima Khan Aamir Akram Khowaja Raheela Khowaja Qazi Masroor Maqsood Mehmood Hassan Moin Nida Mustafa Wasif Noor Huma Qureshi Ibrar Rafique Tahir Rasool Rubina Sabir M. Arif N. Saqib Pir Alam Said Abrar Shaikh Bilal Bin Younus Bilal Tahir Salma Tanveer Jamal Zafar NDSP 12: Atherogenic index of plasma as a useful marker of cardiovascular disease risk among Pakistani individuals; a study from the second National Diabetes Survey of Pakistan (NDSP) 2016–2017 Clinical Epidemiology and Global Health Atherogenic index of plasma Cardiovascular risk Dyslipidemia National diabetes survey of Pakistan |
| title | NDSP 12: Atherogenic index of plasma as a useful marker of cardiovascular disease risk among Pakistani individuals; a study from the second National Diabetes Survey of Pakistan (NDSP) 2016–2017 |
| title_full | NDSP 12: Atherogenic index of plasma as a useful marker of cardiovascular disease risk among Pakistani individuals; a study from the second National Diabetes Survey of Pakistan (NDSP) 2016–2017 |
| title_fullStr | NDSP 12: Atherogenic index of plasma as a useful marker of cardiovascular disease risk among Pakistani individuals; a study from the second National Diabetes Survey of Pakistan (NDSP) 2016–2017 |
| title_full_unstemmed | NDSP 12: Atherogenic index of plasma as a useful marker of cardiovascular disease risk among Pakistani individuals; a study from the second National Diabetes Survey of Pakistan (NDSP) 2016–2017 |
| title_short | NDSP 12: Atherogenic index of plasma as a useful marker of cardiovascular disease risk among Pakistani individuals; a study from the second National Diabetes Survey of Pakistan (NDSP) 2016–2017 |
| title_sort | ndsp 12 atherogenic index of plasma as a useful marker of cardiovascular disease risk among pakistani individuals a study from the second national diabetes survey of pakistan ndsp 2016 2017 |
| topic | Atherogenic index of plasma Cardiovascular risk Dyslipidemia National diabetes survey of Pakistan |
| url | http://www.sciencedirect.com/science/article/pii/S2213398422002457 |
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