Suppression of TREX1 deficiency-induced cellular senescence and interferonopathies by inhibition of DNA damage response
Summary: TREX1 encodes a major DNA exonuclease and mutations of this gene are associated with type I interferonopathies in human. Mice with Trex1 deletion or mutation have shortened life spans accompanied by a senescence-associated secretory phenotype. However, the contribution of cellular senescenc...
Main Authors: | Hekang Du, Nanyang Xiao, Sitong Zhang, Xueyuan Zhou, Yangfan Zhang, Zengzeng Lu, Yuqian Fu, Miaohui Huang, Shan Xu, Qi Chen |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2023-07-01
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Series: | iScience |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004223011677 |
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