Dynamic loading leads to increased metabolic activity and spatial redistribution of viable cell density in nucleus pulposus tissue

Dynamic loading leads to increased metabolic activity and spatial redistribution of viable cell density in nucleus pulposus tissue

Abstract Background Nucleus pulposus (NP) cell density is orchestrated by an interplay between nutrient supply and metabolite accumulation. Physiological loading is essential for tissue homeostasis. However, dynamic loading is also believed to increase metabolic activity and could thereby interfere...

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Bibliographic Details
Main Authors: Elias Salzer, Vivian H. M. Mouser, Jurgen A. Bulsink, Marianna A. Tryfonidou, Keita Ito
Format: Article
Language:English
Published: Wiley 2023-03-01
Series:JOR Spine
Subjects:
ex vivo
glucose
intervertebral disc
mechanobiology
metabolism
nutrition
Online Access:https://doi.org/10.1002/jsp2.1240

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