The role of BMP4 in adipose-derived stem cell differentiation: A minireview
Bone morphogenetic protein 4 (BMP4) is a member of the transforming growth factor beta (TGF-β) superfamily of cytokines responsible for stem cells’ commitment to differentiation, proliferation, and maturation. To date, various studies have utilized BMP4 as a chemical inducer for in vitro differentia...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2022.1045103/full |
| _version_ | 1797990472630665216 |
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| author | Abdul Malik Setiawan Abdul Malik Setiawan Taty Anna Kamarudin Norzana Abd Ghafar |
| author_facet | Abdul Malik Setiawan Abdul Malik Setiawan Taty Anna Kamarudin Norzana Abd Ghafar |
| author_sort | Abdul Malik Setiawan |
| collection | DOAJ |
| description | Bone morphogenetic protein 4 (BMP4) is a member of the transforming growth factor beta (TGF-β) superfamily of cytokines responsible for stem cells’ commitment to differentiation, proliferation, and maturation. To date, various studies have utilized BMP4 as a chemical inducer for in vitro differentiation of human mesenchymal stem cells (MSCs) based on its potential. BMP4 drives in vitro differentiation of ADSC via TGF-β signaling pathway by interactions with BMP receptors leading to the activation of smad-dependent and smad-independent pathways. The BMP4 signaling pathways are regulated by intracellular and extracellular BMP4 antagonists. Extracellular BMP4 antagonist prevents interaction between BMP4 ligand to its receptors, while intracellular BMP4 antagonist shutdowns the smad-dependent pathways through multiple mechanisms. BMP4 proved as one of the popular differentiation factors to induce ADSC differentiation into cell from mesodermal origin. However, addition of all-trans retinoic acid is also needed in trans-differentiation of ADSC into ectodermal lineage cells. Suggesting that both BMP4 and RA signaling pathways may be necessary to be activated for in vitro trans-differentiation of ADSC. |
| first_indexed | 2024-04-11T08:35:53Z |
| format | Article |
| id | doaj.art-d721d8614fc2406c9102222284809bd9 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-04-11T08:35:53Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-d721d8614fc2406c9102222284809bd92022-12-22T04:34:19ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2022-10-011010.3389/fcell.2022.10451031045103The role of BMP4 in adipose-derived stem cell differentiation: A minireviewAbdul Malik Setiawan0Abdul Malik Setiawan1Taty Anna Kamarudin2Norzana Abd Ghafar3Department of Anatomy, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, MalaysiaDepartment of Anatomy, Maulana Malik Ibrahim State Islamic University, Malang, IndonesiaDepartment of Anatomy, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, MalaysiaDepartment of Anatomy, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, MalaysiaBone morphogenetic protein 4 (BMP4) is a member of the transforming growth factor beta (TGF-β) superfamily of cytokines responsible for stem cells’ commitment to differentiation, proliferation, and maturation. To date, various studies have utilized BMP4 as a chemical inducer for in vitro differentiation of human mesenchymal stem cells (MSCs) based on its potential. BMP4 drives in vitro differentiation of ADSC via TGF-β signaling pathway by interactions with BMP receptors leading to the activation of smad-dependent and smad-independent pathways. The BMP4 signaling pathways are regulated by intracellular and extracellular BMP4 antagonists. Extracellular BMP4 antagonist prevents interaction between BMP4 ligand to its receptors, while intracellular BMP4 antagonist shutdowns the smad-dependent pathways through multiple mechanisms. BMP4 proved as one of the popular differentiation factors to induce ADSC differentiation into cell from mesodermal origin. However, addition of all-trans retinoic acid is also needed in trans-differentiation of ADSC into ectodermal lineage cells. Suggesting that both BMP4 and RA signaling pathways may be necessary to be activated for in vitro trans-differentiation of ADSC.https://www.frontiersin.org/articles/10.3389/fcell.2022.1045103/fullBMP4ADSClineagedifferentiationsignaling |
| spellingShingle | Abdul Malik Setiawan Abdul Malik Setiawan Taty Anna Kamarudin Norzana Abd Ghafar The role of BMP4 in adipose-derived stem cell differentiation: A minireview Frontiers in Cell and Developmental Biology BMP4 ADSC lineage differentiation signaling |
| title | The role of BMP4 in adipose-derived stem cell differentiation: A minireview |
| title_full | The role of BMP4 in adipose-derived stem cell differentiation: A minireview |
| title_fullStr | The role of BMP4 in adipose-derived stem cell differentiation: A minireview |
| title_full_unstemmed | The role of BMP4 in adipose-derived stem cell differentiation: A minireview |
| title_short | The role of BMP4 in adipose-derived stem cell differentiation: A minireview |
| title_sort | role of bmp4 in adipose derived stem cell differentiation a minireview |
| topic | BMP4 ADSC lineage differentiation signaling |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2022.1045103/full |
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