Early depressive symptoms and disability accrual in Multiple Sclerosis: a UK MS Register study
Abstract Understanding the associations and potential drivers of long-term disability in Multiple Sclerosis (MS) is of clinical and prognostic value. Previous data have suggested a link between depression and disability accrual in MS. We aimed to determine whether depression in early MS predicts sub...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-05-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-34545-6 |
| _version_ | 1797818020918198272 |
|---|---|
| author | Benjamin M. Jacobs Cyrus Daruwalla Mollie O. McKeon Raghda Al-Najjar Andrea Simcock-Davies Katherine Tuite-Dalton J. William L. Brown Ruth Dobson Jeff Rodgers Rod Middleton |
| author_facet | Benjamin M. Jacobs Cyrus Daruwalla Mollie O. McKeon Raghda Al-Najjar Andrea Simcock-Davies Katherine Tuite-Dalton J. William L. Brown Ruth Dobson Jeff Rodgers Rod Middleton |
| author_sort | Benjamin M. Jacobs |
| collection | DOAJ |
| description | Abstract Understanding the associations and potential drivers of long-term disability in Multiple Sclerosis (MS) is of clinical and prognostic value. Previous data have suggested a link between depression and disability accrual in MS. We aimed to determine whether depression in early MS predicts subsequent accrual of disability. Using data from the UK MS Register, we identified individuals with and without symptoms of depression and anxiety close to disease onset. We used Cox proportional hazards regression to evaluate whether early depressive or anxiety symptoms predict subsequent physical disability worsening, measured using the Expanded Disability Status Scale (EDSS). We analysed data from 862 people with MS of whom 134 (15.5%) reached an EDSS of ≥ 6.0. Early depressive symptoms were associated with an increased risk of reaching an EDSS of 6.0 (HR 2.42, 95% CI 1.49–3.95, p < 0.001), however this effect dissipated when adjusting for baseline EDSS (HR 1.40, 95% CI 0.84–2.32, p = 0.2). These data suggest that early depressive symptoms in MS are associated with subsequent disability accrual, but are likely the result of disability rather than its cause. |
| first_indexed | 2024-03-13T09:03:05Z |
| format | Article |
| id | doaj.art-d72350bc2bba4056a62e8cab9c02ceb1 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-13T09:03:05Z |
| publishDate | 2023-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-d72350bc2bba4056a62e8cab9c02ceb12023-05-28T11:15:44ZengNature PortfolioScientific Reports2045-23222023-05-011311610.1038/s41598-023-34545-6Early depressive symptoms and disability accrual in Multiple Sclerosis: a UK MS Register studyBenjamin M. Jacobs0Cyrus Daruwalla1Mollie O. McKeon2Raghda Al-Najjar3Andrea Simcock-Davies4Katherine Tuite-Dalton5J. William L. Brown6Ruth Dobson7Jeff Rodgers8Rod Middleton9Preventive Neurology Unit, Wolfson Institute of Population Health, Queen Mary University of LondonDepartment of Clinical Neurosciences, University of CambridgeDepartment of Clinical Neurosciences, University of CambridgeDepartment of Clinical Neurosciences, University of CambridgePopulation Data Science, Swansea University Medical SchoolPopulation Data Science, Swansea University Medical SchoolDepartment of Clinical Neurosciences, University of CambridgePreventive Neurology Unit, Wolfson Institute of Population Health, Queen Mary University of LondonPopulation Data Science, Swansea University Medical SchoolPopulation Data Science, Swansea University Medical SchoolAbstract Understanding the associations and potential drivers of long-term disability in Multiple Sclerosis (MS) is of clinical and prognostic value. Previous data have suggested a link between depression and disability accrual in MS. We aimed to determine whether depression in early MS predicts subsequent accrual of disability. Using data from the UK MS Register, we identified individuals with and without symptoms of depression and anxiety close to disease onset. We used Cox proportional hazards regression to evaluate whether early depressive or anxiety symptoms predict subsequent physical disability worsening, measured using the Expanded Disability Status Scale (EDSS). We analysed data from 862 people with MS of whom 134 (15.5%) reached an EDSS of ≥ 6.0. Early depressive symptoms were associated with an increased risk of reaching an EDSS of 6.0 (HR 2.42, 95% CI 1.49–3.95, p < 0.001), however this effect dissipated when adjusting for baseline EDSS (HR 1.40, 95% CI 0.84–2.32, p = 0.2). These data suggest that early depressive symptoms in MS are associated with subsequent disability accrual, but are likely the result of disability rather than its cause.https://doi.org/10.1038/s41598-023-34545-6 |
| spellingShingle | Benjamin M. Jacobs Cyrus Daruwalla Mollie O. McKeon Raghda Al-Najjar Andrea Simcock-Davies Katherine Tuite-Dalton J. William L. Brown Ruth Dobson Jeff Rodgers Rod Middleton Early depressive symptoms and disability accrual in Multiple Sclerosis: a UK MS Register study Scientific Reports |
| title | Early depressive symptoms and disability accrual in Multiple Sclerosis: a UK MS Register study |
| title_full | Early depressive symptoms and disability accrual in Multiple Sclerosis: a UK MS Register study |
| title_fullStr | Early depressive symptoms and disability accrual in Multiple Sclerosis: a UK MS Register study |
| title_full_unstemmed | Early depressive symptoms and disability accrual in Multiple Sclerosis: a UK MS Register study |
| title_short | Early depressive symptoms and disability accrual in Multiple Sclerosis: a UK MS Register study |
| title_sort | early depressive symptoms and disability accrual in multiple sclerosis a uk ms register study |
| url | https://doi.org/10.1038/s41598-023-34545-6 |
| work_keys_str_mv | AT benjaminmjacobs earlydepressivesymptomsanddisabilityaccrualinmultiplesclerosisaukmsregisterstudy AT cyrusdaruwalla earlydepressivesymptomsanddisabilityaccrualinmultiplesclerosisaukmsregisterstudy AT mollieomckeon earlydepressivesymptomsanddisabilityaccrualinmultiplesclerosisaukmsregisterstudy AT raghdaalnajjar earlydepressivesymptomsanddisabilityaccrualinmultiplesclerosisaukmsregisterstudy AT andreasimcockdavies earlydepressivesymptomsanddisabilityaccrualinmultiplesclerosisaukmsregisterstudy AT katherinetuitedalton earlydepressivesymptomsanddisabilityaccrualinmultiplesclerosisaukmsregisterstudy AT jwilliamlbrown earlydepressivesymptomsanddisabilityaccrualinmultiplesclerosisaukmsregisterstudy AT ruthdobson earlydepressivesymptomsanddisabilityaccrualinmultiplesclerosisaukmsregisterstudy AT jeffrodgers earlydepressivesymptomsanddisabilityaccrualinmultiplesclerosisaukmsregisterstudy AT rodmiddleton earlydepressivesymptomsanddisabilityaccrualinmultiplesclerosisaukmsregisterstudy |