Plasma concentrations of tris(1-chloro-2-propyl) phosphate and a metabolite bis(2-chloroisopropyl) 1-carboxyethyl phosphate in Sprague-Dawley rats and B6C3F1/N mice from a chronic study of tris(chloropropyl) phosphate via feed
Tris(chloropropyl) phosphate (TCPP) is an organophosphorus flame retardant and plasticizer used in manufacturing and multiple consumer products. Commercial TCPP is a ubiquitous environmental contaminant and TCPP or its metabolites have been detected in human plasma and urine. In response to the demo...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Toxicology Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214750022000555 |
| _version_ | 1811178666221109248 |
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| author | Bradley Collins Desmond Slade Kristin Aillon Matthew Stout Laura Betz Suramya Waidyanatha Kristen Ryan |
| author_facet | Bradley Collins Desmond Slade Kristin Aillon Matthew Stout Laura Betz Suramya Waidyanatha Kristen Ryan |
| author_sort | Bradley Collins |
| collection | DOAJ |
| description | Tris(chloropropyl) phosphate (TCPP) is an organophosphorus flame retardant and plasticizer used in manufacturing and multiple consumer products. Commercial TCPP is a ubiquitous environmental contaminant and TCPP or its metabolites have been detected in human plasma and urine. In response to the demonstrated widespread human exposure and lack of toxicity data, the Division of the National Toxicology Program is investigating the chronic toxicity of TCPP following perinatal exposure in HSD:Sprague Dawley®SD® (HSD) rats (up to 20,000 ppm) and adult exposure in B6C3F1/N mice (females, up to 10,000 ppm; males up to 5000 ppm) to TCPP via feed. Systemic exposure and bioaccumulation were assessed by measuring plasma concentrations of tris(1-chloro-2-propyl)phosphate (TCIPP), the most abundant TCPP isomer. TCIPP concentrations in TCPP-exposed rats and mice ranged from 3.43 to 1180 ng/mL and increased with exposure concentration at all time points. No sex differences were observed in rats, but male mice had higher TCIPP concentrations than females. TCIPP did not bioaccumulate in rats or mice over the course of the study. Low TCIPP concentrations were seen in some control rats and mice that were attributed to background TCPP present during sample collection, preparation and/or analysis. Bis(2-chloroisopropyl) 1-carboxyethyl phosphate (BCPCP), a TCPP metabolite, was quantified in plasma from control and selected exposed animals. Results showed increases in BCPCP concentration that were proportional to exposure concentration in rats and mice at concentrations much higher than TCIPP, indicating that BCPCP might be a more suitable biomarker of TCPP exposure. |
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| language | English |
| last_indexed | 2024-04-11T06:23:24Z |
| publishDate | 2022-01-01 |
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| series | Toxicology Reports |
| spelling | doaj.art-d723729e049a4c0784349184ae7af2e22022-12-22T04:40:30ZengElsevierToxicology Reports2214-75002022-01-019690698Plasma concentrations of tris(1-chloro-2-propyl) phosphate and a metabolite bis(2-chloroisopropyl) 1-carboxyethyl phosphate in Sprague-Dawley rats and B6C3F1/N mice from a chronic study of tris(chloropropyl) phosphate via feedBradley Collins0Desmond Slade1Kristin Aillon2Matthew Stout3Laura Betz4Suramya Waidyanatha5Kristen Ryan6National Institute of Environmental Health Sciences, Division of the National Toxicology Program, RTP, NC 27709-2233, USA; Correspondence to: National Institute of Environmental Health Sciences, 111 T.W. Alexander Drive, MD K2–07, Research Triangle Park, NC 27709, USA.MRIGlobal, Kansas City, MO 64110-2299, USAMRIGlobal, Kansas City, MO 64110-2299, USANational Institute of Environmental Health Sciences, Division of the National Toxicology Program, RTP, NC 27709-2233, USASocial and Scientific Systems, Inc., Durham, NC 27703, USANational Institute of Environmental Health Sciences, Division of the National Toxicology Program, RTP, NC 27709-2233, USANational Institute of Environmental Health Sciences, Division of the National Toxicology Program, RTP, NC 27709-2233, USATris(chloropropyl) phosphate (TCPP) is an organophosphorus flame retardant and plasticizer used in manufacturing and multiple consumer products. Commercial TCPP is a ubiquitous environmental contaminant and TCPP or its metabolites have been detected in human plasma and urine. In response to the demonstrated widespread human exposure and lack of toxicity data, the Division of the National Toxicology Program is investigating the chronic toxicity of TCPP following perinatal exposure in HSD:Sprague Dawley®SD® (HSD) rats (up to 20,000 ppm) and adult exposure in B6C3F1/N mice (females, up to 10,000 ppm; males up to 5000 ppm) to TCPP via feed. Systemic exposure and bioaccumulation were assessed by measuring plasma concentrations of tris(1-chloro-2-propyl)phosphate (TCIPP), the most abundant TCPP isomer. TCIPP concentrations in TCPP-exposed rats and mice ranged from 3.43 to 1180 ng/mL and increased with exposure concentration at all time points. No sex differences were observed in rats, but male mice had higher TCIPP concentrations than females. TCIPP did not bioaccumulate in rats or mice over the course of the study. Low TCIPP concentrations were seen in some control rats and mice that were attributed to background TCPP present during sample collection, preparation and/or analysis. Bis(2-chloroisopropyl) 1-carboxyethyl phosphate (BCPCP), a TCPP metabolite, was quantified in plasma from control and selected exposed animals. Results showed increases in BCPCP concentration that were proportional to exposure concentration in rats and mice at concentrations much higher than TCIPP, indicating that BCPCP might be a more suitable biomarker of TCPP exposure.http://www.sciencedirect.com/science/article/pii/S2214750022000555Tris(chloropropyl)phosphateTris(1-chloro-2-propyl)phosphateTCIPPBis(2-chloroisopropyl) 1-carboxyethyl phosphateSprague-Dawley ratB6C3F1/N mouse |
| spellingShingle | Bradley Collins Desmond Slade Kristin Aillon Matthew Stout Laura Betz Suramya Waidyanatha Kristen Ryan Plasma concentrations of tris(1-chloro-2-propyl) phosphate and a metabolite bis(2-chloroisopropyl) 1-carboxyethyl phosphate in Sprague-Dawley rats and B6C3F1/N mice from a chronic study of tris(chloropropyl) phosphate via feed Toxicology Reports Tris(chloropropyl)phosphate Tris(1-chloro-2-propyl)phosphate TCIPP Bis(2-chloroisopropyl) 1-carboxyethyl phosphate Sprague-Dawley rat B6C3F1/N mouse |
| title | Plasma concentrations of tris(1-chloro-2-propyl) phosphate and a metabolite bis(2-chloroisopropyl) 1-carboxyethyl phosphate in Sprague-Dawley rats and B6C3F1/N mice from a chronic study of tris(chloropropyl) phosphate via feed |
| title_full | Plasma concentrations of tris(1-chloro-2-propyl) phosphate and a metabolite bis(2-chloroisopropyl) 1-carboxyethyl phosphate in Sprague-Dawley rats and B6C3F1/N mice from a chronic study of tris(chloropropyl) phosphate via feed |
| title_fullStr | Plasma concentrations of tris(1-chloro-2-propyl) phosphate and a metabolite bis(2-chloroisopropyl) 1-carboxyethyl phosphate in Sprague-Dawley rats and B6C3F1/N mice from a chronic study of tris(chloropropyl) phosphate via feed |
| title_full_unstemmed | Plasma concentrations of tris(1-chloro-2-propyl) phosphate and a metabolite bis(2-chloroisopropyl) 1-carboxyethyl phosphate in Sprague-Dawley rats and B6C3F1/N mice from a chronic study of tris(chloropropyl) phosphate via feed |
| title_short | Plasma concentrations of tris(1-chloro-2-propyl) phosphate and a metabolite bis(2-chloroisopropyl) 1-carboxyethyl phosphate in Sprague-Dawley rats and B6C3F1/N mice from a chronic study of tris(chloropropyl) phosphate via feed |
| title_sort | plasma concentrations of tris 1 chloro 2 propyl phosphate and a metabolite bis 2 chloroisopropyl 1 carboxyethyl phosphate in sprague dawley rats and b6c3f1 n mice from a chronic study of tris chloropropyl phosphate via feed |
| topic | Tris(chloropropyl)phosphate Tris(1-chloro-2-propyl)phosphate TCIPP Bis(2-chloroisopropyl) 1-carboxyethyl phosphate Sprague-Dawley rat B6C3F1/N mouse |
| url | http://www.sciencedirect.com/science/article/pii/S2214750022000555 |
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