Persistence of protective anti-HBs antibody levels and anamnestic response to HBV booster vaccination: A cross-sectional study among healthcare students 20 years following the universal immunization campaign in Italy
Vaccination against Hepatitis B Virus (HBV) became mandatory in Italy for all newborns and 12 years-old individuals in the 1991. The immunogenicity of HBV vaccine and the effectiveness of the universal immunization strategy have been widely demonstrated. However the need to assess the antibody conce...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2017-02-01
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| Series: | Human Vaccines & Immunotherapeutics |
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| Online Access: | http://dx.doi.org/10.1080/21645515.2017.1264788 |
| _version_ | 1797674578336546816 |
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| author | Guglielmo Dini Alessandra Toletone Ilaria Barberis Nicoletta Debarbieri Emanuela Massa Chiara Paganino Francesca Bersi Alfredo Montecucco Cristiano Alicino Paolo Durando |
| author_facet | Guglielmo Dini Alessandra Toletone Ilaria Barberis Nicoletta Debarbieri Emanuela Massa Chiara Paganino Francesca Bersi Alfredo Montecucco Cristiano Alicino Paolo Durando |
| author_sort | Guglielmo Dini |
| collection | DOAJ |
| description | Vaccination against Hepatitis B Virus (HBV) became mandatory in Italy for all newborns and 12 years-old individuals in the 1991. The immunogenicity of HBV vaccine and the effectiveness of the universal immunization strategy have been widely demonstrated. However the need to assess the antibody concentrations above the well known serological correlate of protection for HBV infection (≥10 mIU/mL), established in individuals immunized with a 3 doses vaccination course, is still recommended in subjects exposed to occupational risks in different settings, particularly the healthcare services. This practice has to be performed during the preventive medical examination, before the worker's exposure to biological hazards, as a fundamental part of Occupational Health Surveillance Programs in several Countries, including Italy: the goal is to assure individual protection, also providing booster doses when needed, after many years following the primary vaccination. During the 2011–2013 period, an observational study was performed in Healthcare students (HCSs) trained at a regional university acute-care hospital in North-Western Italy, properly immunized against HBV during infancy or adolescence, in order to evaluate the persistence of seroprotection and to assess the anamnestic response to booster vaccination. Data from 717 subjects undergoing HbsAg Ab and HBc Ab testing during the preventive medical examination, and receiving a booster dose of HBV vaccine when resulting with a non-protective titer (<10 mIU/mL), were collected and analyzed. Most of the HCSs (74.6%) included in the survey, mean age 24.8 y ( ± 4.6 SD), had received the primary vaccination course during the first year of life (3–5–11 months). Globally, 507 (70.7%) HCSs showed protective antibody titres, and an anamnestic response was observed in more than 95% subjects receiving the booster dose. Our study demonstrated the long-term persistence of protection of HBV vaccine, more than 20 y following the primary immunization, in HCSs who are exposed to occupational health risk. The anamnestic response observed in non-seroprotected subjects who received the booster further confirms the capability of the HBV vaccine to create a strong immunological memory. |
| first_indexed | 2024-03-11T22:01:06Z |
| format | Article |
| id | doaj.art-d7238809e34c4c80a59010000c44c30e |
| institution | Directory Open Access Journal |
| issn | 2164-5515 2164-554X |
| language | English |
| last_indexed | 2024-03-11T22:01:06Z |
| publishDate | 2017-02-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj.art-d7238809e34c4c80a59010000c44c30e2023-09-25T11:02:54ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2017-02-0113244044410.1080/21645515.2017.12647881264788Persistence of protective anti-HBs antibody levels and anamnestic response to HBV booster vaccination: A cross-sectional study among healthcare students 20 years following the universal immunization campaign in ItalyGuglielmo Dini0Alessandra Toletone1Ilaria Barberis2Nicoletta Debarbieri3Emanuela Massa4Chiara Paganino5Francesca Bersi6Alfredo Montecucco7Cristiano Alicino8Paolo Durando9Postgraduate School in Occupational Medicine, University of Genoa and Occupational Medicine Unit, I.R.C.C.S. University Hospital San Martino - IST National Institute for Cancer ResearchPostgraduate School in Occupational Medicine, University of Genoa and Occupational Medicine Unit, I.R.C.C.S. University Hospital San Martino - IST National Institute for Cancer ResearchUniversity of GenoaPostgraduate School in Occupational Medicine, University of Genoa and Occupational Medicine Unit, I.R.C.C.S. University Hospital San Martino - IST National Institute for Cancer ResearchPostgraduate School in Occupational Medicine, University of Genoa and Occupational Medicine Unit, I.R.C.C.S. University Hospital San Martino - IST National Institute for Cancer ResearchUniversity of GenoaPostgraduate School in Occupational Medicine, University of Genoa and Occupational Medicine Unit, I.R.C.C.S. University Hospital San Martino - IST National Institute for Cancer ResearchPostgraduate School in Occupational Medicine, University of Genoa and Occupational Medicine Unit, I.R.C.C.S. University Hospital San Martino - IST National Institute for Cancer ResearchUniversity of GenoaPostgraduate School in Occupational Medicine, University of Genoa and Occupational Medicine Unit, I.R.C.C.S. University Hospital San Martino - IST National Institute for Cancer ResearchVaccination against Hepatitis B Virus (HBV) became mandatory in Italy for all newborns and 12 years-old individuals in the 1991. The immunogenicity of HBV vaccine and the effectiveness of the universal immunization strategy have been widely demonstrated. However the need to assess the antibody concentrations above the well known serological correlate of protection for HBV infection (≥10 mIU/mL), established in individuals immunized with a 3 doses vaccination course, is still recommended in subjects exposed to occupational risks in different settings, particularly the healthcare services. This practice has to be performed during the preventive medical examination, before the worker's exposure to biological hazards, as a fundamental part of Occupational Health Surveillance Programs in several Countries, including Italy: the goal is to assure individual protection, also providing booster doses when needed, after many years following the primary vaccination. During the 2011–2013 period, an observational study was performed in Healthcare students (HCSs) trained at a regional university acute-care hospital in North-Western Italy, properly immunized against HBV during infancy or adolescence, in order to evaluate the persistence of seroprotection and to assess the anamnestic response to booster vaccination. Data from 717 subjects undergoing HbsAg Ab and HBc Ab testing during the preventive medical examination, and receiving a booster dose of HBV vaccine when resulting with a non-protective titer (<10 mIU/mL), were collected and analyzed. Most of the HCSs (74.6%) included in the survey, mean age 24.8 y ( ± 4.6 SD), had received the primary vaccination course during the first year of life (3–5–11 months). Globally, 507 (70.7%) HCSs showed protective antibody titres, and an anamnestic response was observed in more than 95% subjects receiving the booster dose. Our study demonstrated the long-term persistence of protection of HBV vaccine, more than 20 y following the primary immunization, in HCSs who are exposed to occupational health risk. The anamnestic response observed in non-seroprotected subjects who received the booster further confirms the capability of the HBV vaccine to create a strong immunological memory.http://dx.doi.org/10.1080/21645515.2017.1264788anamnestic responsehepatitis b virus (hbv)occupational health surveillance programspersistence of protectionvaccine |
| spellingShingle | Guglielmo Dini Alessandra Toletone Ilaria Barberis Nicoletta Debarbieri Emanuela Massa Chiara Paganino Francesca Bersi Alfredo Montecucco Cristiano Alicino Paolo Durando Persistence of protective anti-HBs antibody levels and anamnestic response to HBV booster vaccination: A cross-sectional study among healthcare students 20 years following the universal immunization campaign in Italy Human Vaccines & Immunotherapeutics anamnestic response hepatitis b virus (hbv) occupational health surveillance programs persistence of protection vaccine |
| title | Persistence of protective anti-HBs antibody levels and anamnestic response to HBV booster vaccination: A cross-sectional study among healthcare students 20 years following the universal immunization campaign in Italy |
| title_full | Persistence of protective anti-HBs antibody levels and anamnestic response to HBV booster vaccination: A cross-sectional study among healthcare students 20 years following the universal immunization campaign in Italy |
| title_fullStr | Persistence of protective anti-HBs antibody levels and anamnestic response to HBV booster vaccination: A cross-sectional study among healthcare students 20 years following the universal immunization campaign in Italy |
| title_full_unstemmed | Persistence of protective anti-HBs antibody levels and anamnestic response to HBV booster vaccination: A cross-sectional study among healthcare students 20 years following the universal immunization campaign in Italy |
| title_short | Persistence of protective anti-HBs antibody levels and anamnestic response to HBV booster vaccination: A cross-sectional study among healthcare students 20 years following the universal immunization campaign in Italy |
| title_sort | persistence of protective anti hbs antibody levels and anamnestic response to hbv booster vaccination a cross sectional study among healthcare students 20 years following the universal immunization campaign in italy |
| topic | anamnestic response hepatitis b virus (hbv) occupational health surveillance programs persistence of protection vaccine |
| url | http://dx.doi.org/10.1080/21645515.2017.1264788 |
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