Apoptotic Cell-Derived Extracellular Vesicles: More Than Just Debris
The many functions of extracellular vesicles (EVs) like exosomes and microvesicles released from healthy cells have been well characterized, particularly in relation to their roles in immune modulation. Apoptotic bodies, a major class of EV released as a product of apoptotic cell disassembly, and ot...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-06-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2018.01486/full |
| _version_ | 1818412867567747072 |
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| author | Sarah Caruso Ivan K. H. Poon |
| author_facet | Sarah Caruso Ivan K. H. Poon |
| author_sort | Sarah Caruso |
| collection | DOAJ |
| description | The many functions of extracellular vesicles (EVs) like exosomes and microvesicles released from healthy cells have been well characterized, particularly in relation to their roles in immune modulation. Apoptotic bodies, a major class of EV released as a product of apoptotic cell disassembly, and other types of EVs released from dying cells are also becoming recognized as key players in this emerging field. There is now increasing evidence to suggest that EVs produced during apoptosis have important immune regulatory roles, a concept relevant across different disease settings including autoimmunity, cancer, and infection. Therefore, this review focuses on how the formation of EVs during apoptosis could be a key mechanism of immune modulation by dying cells. |
| first_indexed | 2024-12-14T10:54:08Z |
| format | Article |
| id | doaj.art-d7243078503047fbb228287243c21952 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-14T10:54:08Z |
| publishDate | 2018-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-d7243078503047fbb228287243c219522022-12-21T23:05:03ZengFrontiers Media S.A.Frontiers in Immunology1664-32242018-06-01910.3389/fimmu.2018.01486368751Apoptotic Cell-Derived Extracellular Vesicles: More Than Just DebrisSarah CarusoIvan K. H. PoonThe many functions of extracellular vesicles (EVs) like exosomes and microvesicles released from healthy cells have been well characterized, particularly in relation to their roles in immune modulation. Apoptotic bodies, a major class of EV released as a product of apoptotic cell disassembly, and other types of EVs released from dying cells are also becoming recognized as key players in this emerging field. There is now increasing evidence to suggest that EVs produced during apoptosis have important immune regulatory roles, a concept relevant across different disease settings including autoimmunity, cancer, and infection. Therefore, this review focuses on how the formation of EVs during apoptosis could be a key mechanism of immune modulation by dying cells.https://www.frontiersin.org/article/10.3389/fimmu.2018.01486/fullapoptotic bodiesapoptotic microvesiclesextracellular vesiclesimmunomodulationapoptosis |
| spellingShingle | Sarah Caruso Ivan K. H. Poon Apoptotic Cell-Derived Extracellular Vesicles: More Than Just Debris Frontiers in Immunology apoptotic bodies apoptotic microvesicles extracellular vesicles immunomodulation apoptosis |
| title | Apoptotic Cell-Derived Extracellular Vesicles: More Than Just Debris |
| title_full | Apoptotic Cell-Derived Extracellular Vesicles: More Than Just Debris |
| title_fullStr | Apoptotic Cell-Derived Extracellular Vesicles: More Than Just Debris |
| title_full_unstemmed | Apoptotic Cell-Derived Extracellular Vesicles: More Than Just Debris |
| title_short | Apoptotic Cell-Derived Extracellular Vesicles: More Than Just Debris |
| title_sort | apoptotic cell derived extracellular vesicles more than just debris |
| topic | apoptotic bodies apoptotic microvesicles extracellular vesicles immunomodulation apoptosis |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2018.01486/full |
| work_keys_str_mv | AT sarahcaruso apoptoticcellderivedextracellularvesiclesmorethanjustdebris AT ivankhpoon apoptoticcellderivedextracellularvesiclesmorethanjustdebris |