Antioxidant and Anti-Inflammatory Effects of Oral Supplementation with a Highly-Concentrated Docosahexaenoic Acid (DHA) Triglyceride in Patients with Keratoconus: A Randomized Controlled Preliminary Study
A prospective, randomized, single-center preliminary study was performed in patients with keratoconus stages I–III (Amsler–Krumeich), who received a high rich docosahexaenoic acid (DHA) (1000 mg/day) supplement for 3 months versus untreated patients. One eye per patient was evaluated. Thirty-four pa...
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MDPI AG
2023-03-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/5/1300 |
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| author | Cristina Peris-Martínez José Vicente Piá-Ludeña María José Rog-Revert Ester Fernández-López Joan Carles Domingo |
| author_facet | Cristina Peris-Martínez José Vicente Piá-Ludeña María José Rog-Revert Ester Fernández-López Joan Carles Domingo |
| author_sort | Cristina Peris-Martínez |
| collection | DOAJ |
| description | A prospective, randomized, single-center preliminary study was performed in patients with keratoconus stages I–III (Amsler–Krumeich), who received a high rich docosahexaenoic acid (DHA) (1000 mg/day) supplement for 3 months versus untreated patients. One eye per patient was evaluated. Thirty-four patients were recruited (75% men, mean age 31 years), with 15 randomized to the control group and 19 to the DHA-treated group. Corneal topography variables and plasma biomarkers of oxidative stress and inflammatory status were evaluated. A panel of fatty acids in blood samples was also assessed. There were significant between-group differences in the astigmatism axis, asphericity coefficient, and intraocular pressure in favor of the DHA group. Additionally, between-group significant differences in total antioxidant capacity (TAC), malondialdehyde (MDA), free glutathione (GSH) and GSH/GSSG ratio, as well as reduced values of inflammatory markers, including interleukin (IL)-4, IL-6, and vascular endothelial growth factor (VEGF-A) were found. These preliminary findings support the usefulness of the antioxidant and anti-inflammatory effects of DHA supplementation for targeting underlying pathophysiological mechanisms of keratoconus. Prolonged duration of DHA supplementation may be needed to detect more noticeable clinical changes in corneal topography. |
| first_indexed | 2024-03-11T07:15:00Z |
| format | Article |
| id | doaj.art-d7246568a80b4766b5e505b97202bafe |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-11T07:15:00Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-d7246568a80b4766b5e505b97202bafe2023-11-17T08:22:23ZengMDPI AGNutrients2072-66432023-03-01155130010.3390/nu15051300Antioxidant and Anti-Inflammatory Effects of Oral Supplementation with a Highly-Concentrated Docosahexaenoic Acid (DHA) Triglyceride in Patients with Keratoconus: A Randomized Controlled Preliminary StudyCristina Peris-Martínez0José Vicente Piá-Ludeña1María José Rog-Revert2Ester Fernández-López3Joan Carles Domingo4Unit of Cornea and Anterior Eye Diseases, FISABIO Medical Ophthalmology (FOM), C/Pío Baroja 12, E-46015 Valencia, SpainUnit of Cornea and Anterior Eye Diseases, FISABIO Medical Ophthalmology (FOM), C/Pío Baroja 12, E-46015 Valencia, SpainUnit of Cornea and Anterior Eye Diseases, FISABIO Medical Ophthalmology (FOM), C/Pío Baroja 12, E-46015 Valencia, SpainUnit of Cornea and Anterior Eye Diseases, FISABIO Medical Ophthalmology (FOM), C/Pío Baroja 12, E-46015 Valencia, SpainDepartment of Biochemistry and Molecular Biomedicine, Faculty of Biology, University of Barcelona, Avinguda Diagonal 643, E-08028 Barcelona, SpainA prospective, randomized, single-center preliminary study was performed in patients with keratoconus stages I–III (Amsler–Krumeich), who received a high rich docosahexaenoic acid (DHA) (1000 mg/day) supplement for 3 months versus untreated patients. One eye per patient was evaluated. Thirty-four patients were recruited (75% men, mean age 31 years), with 15 randomized to the control group and 19 to the DHA-treated group. Corneal topography variables and plasma biomarkers of oxidative stress and inflammatory status were evaluated. A panel of fatty acids in blood samples was also assessed. There were significant between-group differences in the astigmatism axis, asphericity coefficient, and intraocular pressure in favor of the DHA group. Additionally, between-group significant differences in total antioxidant capacity (TAC), malondialdehyde (MDA), free glutathione (GSH) and GSH/GSSG ratio, as well as reduced values of inflammatory markers, including interleukin (IL)-4, IL-6, and vascular endothelial growth factor (VEGF-A) were found. These preliminary findings support the usefulness of the antioxidant and anti-inflammatory effects of DHA supplementation for targeting underlying pathophysiological mechanisms of keratoconus. Prolonged duration of DHA supplementation may be needed to detect more noticeable clinical changes in corneal topography.https://www.mdpi.com/2072-6643/15/5/1300keratoconusdocosahexaenoic acidoxidative stressomega-3 fatty acidsanti-inflammatory |
| spellingShingle | Cristina Peris-Martínez José Vicente Piá-Ludeña María José Rog-Revert Ester Fernández-López Joan Carles Domingo Antioxidant and Anti-Inflammatory Effects of Oral Supplementation with a Highly-Concentrated Docosahexaenoic Acid (DHA) Triglyceride in Patients with Keratoconus: A Randomized Controlled Preliminary Study Nutrients keratoconus docosahexaenoic acid oxidative stress omega-3 fatty acids anti-inflammatory |
| title | Antioxidant and Anti-Inflammatory Effects of Oral Supplementation with a Highly-Concentrated Docosahexaenoic Acid (DHA) Triglyceride in Patients with Keratoconus: A Randomized Controlled Preliminary Study |
| title_full | Antioxidant and Anti-Inflammatory Effects of Oral Supplementation with a Highly-Concentrated Docosahexaenoic Acid (DHA) Triglyceride in Patients with Keratoconus: A Randomized Controlled Preliminary Study |
| title_fullStr | Antioxidant and Anti-Inflammatory Effects of Oral Supplementation with a Highly-Concentrated Docosahexaenoic Acid (DHA) Triglyceride in Patients with Keratoconus: A Randomized Controlled Preliminary Study |
| title_full_unstemmed | Antioxidant and Anti-Inflammatory Effects of Oral Supplementation with a Highly-Concentrated Docosahexaenoic Acid (DHA) Triglyceride in Patients with Keratoconus: A Randomized Controlled Preliminary Study |
| title_short | Antioxidant and Anti-Inflammatory Effects of Oral Supplementation with a Highly-Concentrated Docosahexaenoic Acid (DHA) Triglyceride in Patients with Keratoconus: A Randomized Controlled Preliminary Study |
| title_sort | antioxidant and anti inflammatory effects of oral supplementation with a highly concentrated docosahexaenoic acid dha triglyceride in patients with keratoconus a randomized controlled preliminary study |
| topic | keratoconus docosahexaenoic acid oxidative stress omega-3 fatty acids anti-inflammatory |
| url | https://www.mdpi.com/2072-6643/15/5/1300 |
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