Nanomedicine for Diagnosis and Treatment of Atherosclerosis
Abstract With the changing disease spectrum, atherosclerosis has become increasingly prevalent worldwide and the associated diseases have emerged as the leading cause of death. Due to their fascinating physical, chemical, and biological characteristics, nanomaterials are regarded as a promising tool...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-12-01
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| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.202304294 |
| _version_ | 1797373775372615680 |
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| author | Jingyun Cheng Hui Huang Yu Chen Rong Wu |
| author_facet | Jingyun Cheng Hui Huang Yu Chen Rong Wu |
| author_sort | Jingyun Cheng |
| collection | DOAJ |
| description | Abstract With the changing disease spectrum, atherosclerosis has become increasingly prevalent worldwide and the associated diseases have emerged as the leading cause of death. Due to their fascinating physical, chemical, and biological characteristics, nanomaterials are regarded as a promising tool to tackle enormous challenges in medicine. The emerging discipline of nanomedicine has filled a huge application gap in the atherosclerotic field, ushering a new generation of diagnosis and treatment strategies. Herein, based on the essential pathogenic contributors of atherogenesis, as well as the distinct composition/structural characteristics, synthesis strategies, and surface design of nanoplatforms, the three major application branches (nanodiagnosis, nanotherapy, and nanotheranostic) of nanomedicine in atherosclerosis are elaborated. Then, state‐of‐art studies containing a sequence of representative and significant achievements are summarized in detail with an emphasis on the intrinsic interaction/relationship between nanomedicines and atherosclerosis. Particularly, attention is paid to the biosafety of nanomedicines, which aims to pave the way for future clinical translation of this burgeoning field. Finally, this comprehensive review is concluded by proposing unresolved key scientific issues and sharing the vision and expectation for the future, fully elucidating the closed loop from atherogenesis to the application paradigm of nanomedicines for advancing the early achievement of clinical applications. |
| first_indexed | 2024-03-08T18:55:18Z |
| format | Article |
| id | doaj.art-d724c1eb2eb5496da617df31447ef33b |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-03-08T18:55:18Z |
| publishDate | 2023-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-d724c1eb2eb5496da617df31447ef33b2023-12-28T14:55:39ZengWileyAdvanced Science2198-38442023-12-011036n/an/a10.1002/advs.202304294Nanomedicine for Diagnosis and Treatment of AtherosclerosisJingyun Cheng0Hui Huang1Yu Chen2Rong Wu3Department of Ultrasound Shanghai General Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200080 P. R. ChinaMaterdicine Lab School of Life Sciences Shanghai University Shanghai 200444 P. R. ChinaMaterdicine Lab School of Life Sciences Shanghai University Shanghai 200444 P. R. ChinaDepartment of Ultrasound Shanghai General Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200080 P. R. ChinaAbstract With the changing disease spectrum, atherosclerosis has become increasingly prevalent worldwide and the associated diseases have emerged as the leading cause of death. Due to their fascinating physical, chemical, and biological characteristics, nanomaterials are regarded as a promising tool to tackle enormous challenges in medicine. The emerging discipline of nanomedicine has filled a huge application gap in the atherosclerotic field, ushering a new generation of diagnosis and treatment strategies. Herein, based on the essential pathogenic contributors of atherogenesis, as well as the distinct composition/structural characteristics, synthesis strategies, and surface design of nanoplatforms, the three major application branches (nanodiagnosis, nanotherapy, and nanotheranostic) of nanomedicine in atherosclerosis are elaborated. Then, state‐of‐art studies containing a sequence of representative and significant achievements are summarized in detail with an emphasis on the intrinsic interaction/relationship between nanomedicines and atherosclerosis. Particularly, attention is paid to the biosafety of nanomedicines, which aims to pave the way for future clinical translation of this burgeoning field. Finally, this comprehensive review is concluded by proposing unresolved key scientific issues and sharing the vision and expectation for the future, fully elucidating the closed loop from atherogenesis to the application paradigm of nanomedicines for advancing the early achievement of clinical applications.https://doi.org/10.1002/advs.202304294atherosclerosisbiomaterialsdiagnosisnanomedicinetheranostictherapy |
| spellingShingle | Jingyun Cheng Hui Huang Yu Chen Rong Wu Nanomedicine for Diagnosis and Treatment of Atherosclerosis Advanced Science atherosclerosis biomaterials diagnosis nanomedicine theranostic therapy |
| title | Nanomedicine for Diagnosis and Treatment of Atherosclerosis |
| title_full | Nanomedicine for Diagnosis and Treatment of Atherosclerosis |
| title_fullStr | Nanomedicine for Diagnosis and Treatment of Atherosclerosis |
| title_full_unstemmed | Nanomedicine for Diagnosis and Treatment of Atherosclerosis |
| title_short | Nanomedicine for Diagnosis and Treatment of Atherosclerosis |
| title_sort | nanomedicine for diagnosis and treatment of atherosclerosis |
| topic | atherosclerosis biomaterials diagnosis nanomedicine theranostic therapy |
| url | https://doi.org/10.1002/advs.202304294 |
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