Perineural Invasion Is a Significant Indicator of High Malignant Degree and Poor Prognosis in Esophageal Cancer: A Systematic Review and Meta-Analysis

BackgroundPerineural invasion (PNI) is a malignant metastatic mode of tumors and has been reported in many tumors including esophageal cancer (EC). However, the role of PNI in EC has been reported differently. This systematic review and meta-analysis aims to focus on the role of PNI in EC.MethodsEig...

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Main Authors: Liuyang Bai, Liangying Yan, Yaping Guo, Luyun He, Zhiyan Sun, Wenbo Cao, Jing Lu, Saijun Mo
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Oncology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.816270/full
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author Liuyang Bai
Liangying Yan
Yaping Guo
Yaping Guo
Yaping Guo
Luyun He
Luyun He
Luyun He
Zhiyan Sun
Wenbo Cao
Wenbo Cao
Wenbo Cao
Jing Lu
Jing Lu
Jing Lu
Saijun Mo
Saijun Mo
Saijun Mo
author_facet Liuyang Bai
Liangying Yan
Yaping Guo
Yaping Guo
Yaping Guo
Luyun He
Luyun He
Luyun He
Zhiyan Sun
Wenbo Cao
Wenbo Cao
Wenbo Cao
Jing Lu
Jing Lu
Jing Lu
Saijun Mo
Saijun Mo
Saijun Mo
author_sort Liuyang Bai
collection DOAJ
description BackgroundPerineural invasion (PNI) is a malignant metastatic mode of tumors and has been reported in many tumors including esophageal cancer (EC). However, the role of PNI in EC has been reported differently. This systematic review and meta-analysis aims to focus on the role of PNI in EC.MethodsEight databases of CNKI, VIP, Wanfang, Scopus, Wiley, ISI, PubMed, and EBSCO are used for literature search. The association of PNI with gender, pathological stages of T and N (pT and pN), lymphovascular invasion (LVI), lymph node metastasis, 5-year overall survival (OS), and 5-year disease-free survival (DFS) was examined in the meta-analysis by Revman5.0 Software. The pooled OR/HR and 95% CI were used to assess the risk and prognostic value.ResultsSixty-nine published studies were screened for analysis of PNI in EC. The incidence of PNI in esophageal squamous carcinoma (ESCC) and esophageal adenocarcinoma (EAC) was different, but not statistically significant (p > 0.05). The PNI-positive patients had a significantly higher risk of pT stage (OR = 3.85, 95% CI = 2.45–6.05, p < 0.00001), pN stage (OR = 1.86, 95% CI = 1.52–2.28, p < 0.00001), LVI (OR = 2.44, 95% CI = 1.55–3.85, p = 0.0001), and lymph node metastasis (OR = 2.87, 95% CI = 1.56–5.29, p = 0.0007). Furthermore, the cumulative analysis revealed a significant correlation between PNI and poor OS (HR = 1.37, 95% CI = 1.24–1.51, p < 0.0001), as well as poor DFS (HR = 1.55, 95% CI = 1.38–1.74, p < 0.0001).ConclusionPNI occurrence is significantly related to tumor stage, LVI, lymph node metastasis, OS, and DFS. These results indicate that PNI can serve as an indicator of high malignant degree and poor prognosis in EC.
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spelling doaj.art-d72674dce1f240f991095820ede118d12022-12-22T00:39:04ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-06-011210.3389/fonc.2022.816270816270Perineural Invasion Is a Significant Indicator of High Malignant Degree and Poor Prognosis in Esophageal Cancer: A Systematic Review and Meta-AnalysisLiuyang Bai0Liangying Yan1Yaping Guo2Yaping Guo3Yaping Guo4Luyun He5Luyun He6Luyun He7Zhiyan Sun8Wenbo Cao9Wenbo Cao10Wenbo Cao11Jing Lu12Jing Lu13Jing Lu14Saijun Mo15Saijun Mo16Saijun Mo17Department of Pathophysiology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, ChinaDepartment of Pathophysiology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, ChinaDepartment of Pathophysiology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, ChinaCollaborative Innovation Center of Henan Province for Cancer Chemoprevention, Zhengzhou, ChinaState Key Laboratory of Esophageal Cancer Prevention and Treatment, Zhengzhou, ChinaDepartment of Pathophysiology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, ChinaCollaborative Innovation Center of Henan Province for Cancer Chemoprevention, Zhengzhou, ChinaState Key Laboratory of Esophageal Cancer Prevention and Treatment, Zhengzhou, ChinaDepartment of Special Service, No. 988 Hospital of the Joint Service Support Force of People’s Liberation Army of China (PLA), Zhengzhou, ChinaDepartment of Pathophysiology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, ChinaCollaborative Innovation Center of Henan Province for Cancer Chemoprevention, Zhengzhou, ChinaState Key Laboratory of Esophageal Cancer Prevention and Treatment, Zhengzhou, ChinaDepartment of Pathophysiology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, ChinaCollaborative Innovation Center of Henan Province for Cancer Chemoprevention, Zhengzhou, ChinaState Key Laboratory of Esophageal Cancer Prevention and Treatment, Zhengzhou, ChinaDepartment of Pathophysiology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, ChinaCollaborative Innovation Center of Henan Province for Cancer Chemoprevention, Zhengzhou, ChinaState Key Laboratory of Esophageal Cancer Prevention and Treatment, Zhengzhou, ChinaBackgroundPerineural invasion (PNI) is a malignant metastatic mode of tumors and has been reported in many tumors including esophageal cancer (EC). However, the role of PNI in EC has been reported differently. This systematic review and meta-analysis aims to focus on the role of PNI in EC.MethodsEight databases of CNKI, VIP, Wanfang, Scopus, Wiley, ISI, PubMed, and EBSCO are used for literature search. The association of PNI with gender, pathological stages of T and N (pT and pN), lymphovascular invasion (LVI), lymph node metastasis, 5-year overall survival (OS), and 5-year disease-free survival (DFS) was examined in the meta-analysis by Revman5.0 Software. The pooled OR/HR and 95% CI were used to assess the risk and prognostic value.ResultsSixty-nine published studies were screened for analysis of PNI in EC. The incidence of PNI in esophageal squamous carcinoma (ESCC) and esophageal adenocarcinoma (EAC) was different, but not statistically significant (p > 0.05). The PNI-positive patients had a significantly higher risk of pT stage (OR = 3.85, 95% CI = 2.45–6.05, p < 0.00001), pN stage (OR = 1.86, 95% CI = 1.52–2.28, p < 0.00001), LVI (OR = 2.44, 95% CI = 1.55–3.85, p = 0.0001), and lymph node metastasis (OR = 2.87, 95% CI = 1.56–5.29, p = 0.0007). Furthermore, the cumulative analysis revealed a significant correlation between PNI and poor OS (HR = 1.37, 95% CI = 1.24–1.51, p < 0.0001), as well as poor DFS (HR = 1.55, 95% CI = 1.38–1.74, p < 0.0001).ConclusionPNI occurrence is significantly related to tumor stage, LVI, lymph node metastasis, OS, and DFS. These results indicate that PNI can serve as an indicator of high malignant degree and poor prognosis in EC.https://www.frontiersin.org/articles/10.3389/fonc.2022.816270/fullesophageal cancerperineural invasionlymphovascular invasionlymph node metastasisprognosis
spellingShingle Liuyang Bai
Liangying Yan
Yaping Guo
Yaping Guo
Yaping Guo
Luyun He
Luyun He
Luyun He
Zhiyan Sun
Wenbo Cao
Wenbo Cao
Wenbo Cao
Jing Lu
Jing Lu
Jing Lu
Saijun Mo
Saijun Mo
Saijun Mo
Perineural Invasion Is a Significant Indicator of High Malignant Degree and Poor Prognosis in Esophageal Cancer: A Systematic Review and Meta-Analysis
Frontiers in Oncology
esophageal cancer
perineural invasion
lymphovascular invasion
lymph node metastasis
prognosis
title Perineural Invasion Is a Significant Indicator of High Malignant Degree and Poor Prognosis in Esophageal Cancer: A Systematic Review and Meta-Analysis
title_full Perineural Invasion Is a Significant Indicator of High Malignant Degree and Poor Prognosis in Esophageal Cancer: A Systematic Review and Meta-Analysis
title_fullStr Perineural Invasion Is a Significant Indicator of High Malignant Degree and Poor Prognosis in Esophageal Cancer: A Systematic Review and Meta-Analysis
title_full_unstemmed Perineural Invasion Is a Significant Indicator of High Malignant Degree and Poor Prognosis in Esophageal Cancer: A Systematic Review and Meta-Analysis
title_short Perineural Invasion Is a Significant Indicator of High Malignant Degree and Poor Prognosis in Esophageal Cancer: A Systematic Review and Meta-Analysis
title_sort perineural invasion is a significant indicator of high malignant degree and poor prognosis in esophageal cancer a systematic review and meta analysis
topic esophageal cancer
perineural invasion
lymphovascular invasion
lymph node metastasis
prognosis
url https://www.frontiersin.org/articles/10.3389/fonc.2022.816270/full
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