Fat-Soluble Vitamers: Parent-Child Concordance and Population Epidemiology in the Longitudinal Study of Australian Children
Fat-soluble vitamers (FSV) are a class of diverse organic substances important in a wide range of biological processes, including immune function, vision, bone health, and coagulation. Profiling FSV in parents and children enables insights into gene-environment contributions to their circulating lev...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/23/4990 |
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| author | Githal Randunu Porawakara Arachchige Chris James Pook Beatrix Jones Margaret Coe Richard Saffery Melissa Wake Eric Bruce Thorstensen Justin Martin O’Sullivan on behalf of the Child CheckPoint Team |
| author_facet | Githal Randunu Porawakara Arachchige Chris James Pook Beatrix Jones Margaret Coe Richard Saffery Melissa Wake Eric Bruce Thorstensen Justin Martin O’Sullivan on behalf of the Child CheckPoint Team |
| author_sort | Githal Randunu Porawakara Arachchige |
| collection | DOAJ |
| description | Fat-soluble vitamers (FSV) are a class of diverse organic substances important in a wide range of biological processes, including immune function, vision, bone health, and coagulation. Profiling FSV in parents and children enables insights into gene-environment contributions to their circulating levels, but no studies have reported on the population epidemiology of FSV in these groups as of yet. In this study, we report distributions of FSV, their parent-child concordance and variation by key characteristics for 2490 children (aged 11–12 years) and adults (aged 28–71 years) in the Child Health CheckPoint of the Longitudinal Study of Australian Children. Ten A, D, E and K vitamers were quantified using a novel automated LC-MS/MS method. All three K vitamers (i.e., K1, MK-4, MK-7) and 1-α-25(OH)<sub>2</sub>D<sub>3</sub> were below the instrument detection limit and were removed from the present analysis. We observed a strong vitamer-specific parent-child concordance for the six quantifiable A, D and E FSVs. FSV concentrations all varied by age, BMI, and sex. We provide the first cross-sectional population values for multiple FSV. Future studies could examine relative genetic vs. environmental determinants of FSV, how FSV values change longitudinally, and how they contribute to future health and disease. |
| first_indexed | 2024-03-09T17:38:07Z |
| format | Article |
| id | doaj.art-d72a38a01f9541f582979b38e8ec1ab7 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T17:38:07Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-d72a38a01f9541f582979b38e8ec1ab72023-11-24T11:50:18ZengMDPI AGNutrients2072-66432022-11-011423499010.3390/nu14234990Fat-Soluble Vitamers: Parent-Child Concordance and Population Epidemiology in the Longitudinal Study of Australian ChildrenGithal Randunu Porawakara Arachchige0Chris James Pook1Beatrix Jones2Margaret Coe3Richard Saffery4Melissa Wake5Eric Bruce Thorstensen6Justin Martin O’Sullivan7on behalf of the Child CheckPoint TeamThe Liggins Institute, The University of Auckland, Auckland 1023, New ZealandThe Liggins Institute, The University of Auckland, Auckland 1023, New ZealandDepartment of Statistics, Faculty of Science, The University of Auckland, Auckland 1010, New ZealandThe Liggins Institute, The University of Auckland, Auckland 1023, New ZealandThe Murdoch Children’s Research Institute, Parkville, VIC 3052, AustraliaThe Liggins Institute, The University of Auckland, Auckland 1023, New ZealandThe Liggins Institute, The University of Auckland, Auckland 1023, New ZealandThe Liggins Institute, The University of Auckland, Auckland 1023, New ZealandFat-soluble vitamers (FSV) are a class of diverse organic substances important in a wide range of biological processes, including immune function, vision, bone health, and coagulation. Profiling FSV in parents and children enables insights into gene-environment contributions to their circulating levels, but no studies have reported on the population epidemiology of FSV in these groups as of yet. In this study, we report distributions of FSV, their parent-child concordance and variation by key characteristics for 2490 children (aged 11–12 years) and adults (aged 28–71 years) in the Child Health CheckPoint of the Longitudinal Study of Australian Children. Ten A, D, E and K vitamers were quantified using a novel automated LC-MS/MS method. All three K vitamers (i.e., K1, MK-4, MK-7) and 1-α-25(OH)<sub>2</sub>D<sub>3</sub> were below the instrument detection limit and were removed from the present analysis. We observed a strong vitamer-specific parent-child concordance for the six quantifiable A, D and E FSVs. FSV concentrations all varied by age, BMI, and sex. We provide the first cross-sectional population values for multiple FSV. Future studies could examine relative genetic vs. environmental determinants of FSV, how FSV values change longitudinally, and how they contribute to future health and disease.https://www.mdpi.com/2072-6643/14/23/4990Longitudinal Study of Australian Childrenparentfat-soluble vitamersliquid chromatographytandem mass spectrometry |
| spellingShingle | Githal Randunu Porawakara Arachchige Chris James Pook Beatrix Jones Margaret Coe Richard Saffery Melissa Wake Eric Bruce Thorstensen Justin Martin O’Sullivan on behalf of the Child CheckPoint Team Fat-Soluble Vitamers: Parent-Child Concordance and Population Epidemiology in the Longitudinal Study of Australian Children Nutrients Longitudinal Study of Australian Children parent fat-soluble vitamers liquid chromatography tandem mass spectrometry |
| title | Fat-Soluble Vitamers: Parent-Child Concordance and Population Epidemiology in the Longitudinal Study of Australian Children |
| title_full | Fat-Soluble Vitamers: Parent-Child Concordance and Population Epidemiology in the Longitudinal Study of Australian Children |
| title_fullStr | Fat-Soluble Vitamers: Parent-Child Concordance and Population Epidemiology in the Longitudinal Study of Australian Children |
| title_full_unstemmed | Fat-Soluble Vitamers: Parent-Child Concordance and Population Epidemiology in the Longitudinal Study of Australian Children |
| title_short | Fat-Soluble Vitamers: Parent-Child Concordance and Population Epidemiology in the Longitudinal Study of Australian Children |
| title_sort | fat soluble vitamers parent child concordance and population epidemiology in the longitudinal study of australian children |
| topic | Longitudinal Study of Australian Children parent fat-soluble vitamers liquid chromatography tandem mass spectrometry |
| url | https://www.mdpi.com/2072-6643/14/23/4990 |
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