The Role of Adenine Nucleotide Translocase in the Mitochondrial Permeability Transition
The mitochondrial permeability transition, a Ca<sup>2+</sup>-induced significant increase in permeability of the inner mitochondrial membrane, plays an important role in various pathologies. The mitochondrial permeability transition is caused by induction of the permeability transition p...
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| Format: | Article |
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MDPI AG
2020-12-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/9/12/2686 |
| _version_ | 1827700077772144640 |
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| author | Nickolay Brustovetsky |
| author_facet | Nickolay Brustovetsky |
| author_sort | Nickolay Brustovetsky |
| collection | DOAJ |
| description | The mitochondrial permeability transition, a Ca<sup>2+</sup>-induced significant increase in permeability of the inner mitochondrial membrane, plays an important role in various pathologies. The mitochondrial permeability transition is caused by induction of the permeability transition pore (PTP). Despite significant effort, the molecular composition of the PTP is not completely clear and remains an area of hot debate. The Ca<sup>2+</sup>-modified adenine nucleotide translocase (ANT) and F<sub>0</sub>F<sub>1</sub> ATP synthase are the major contenders for the role of pore in the PTP. This paper briefly overviews experimental results focusing on the role of ANT in the mitochondrial permeability transition and proposes that multiple molecular entities might be responsible for the conductance pathway of the PTP. Consequently, the term PTP cannot be applied to a single specific protein such as ANT or a protein complex such as F<sub>0</sub>F<sub>1</sub> ATP synthase, but rather should comprise a variety of potential contributors to increased permeability of the inner mitochondrial membrane. |
| first_indexed | 2024-03-10T14:04:21Z |
| format | Article |
| id | doaj.art-d72ac74db7204657a45c7c3deb017bbe |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T14:04:21Z |
| publishDate | 2020-12-01 |
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| record_format | Article |
| series | Cells |
| spelling | doaj.art-d72ac74db7204657a45c7c3deb017bbe2023-11-21T00:50:04ZengMDPI AGCells2073-44092020-12-01912268610.3390/cells9122686The Role of Adenine Nucleotide Translocase in the Mitochondrial Permeability TransitionNickolay Brustovetsky0Department of Pharmacology and Toxicology, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USAThe mitochondrial permeability transition, a Ca<sup>2+</sup>-induced significant increase in permeability of the inner mitochondrial membrane, plays an important role in various pathologies. The mitochondrial permeability transition is caused by induction of the permeability transition pore (PTP). Despite significant effort, the molecular composition of the PTP is not completely clear and remains an area of hot debate. The Ca<sup>2+</sup>-modified adenine nucleotide translocase (ANT) and F<sub>0</sub>F<sub>1</sub> ATP synthase are the major contenders for the role of pore in the PTP. This paper briefly overviews experimental results focusing on the role of ANT in the mitochondrial permeability transition and proposes that multiple molecular entities might be responsible for the conductance pathway of the PTP. Consequently, the term PTP cannot be applied to a single specific protein such as ANT or a protein complex such as F<sub>0</sub>F<sub>1</sub> ATP synthase, but rather should comprise a variety of potential contributors to increased permeability of the inner mitochondrial membrane.https://www.mdpi.com/2073-4409/9/12/2686calciumpermeability transition poreadenine nucleotide translocasecyclophilin DF<sub>0</sub>F<sub>1</sub>-ATP synthase |
| spellingShingle | Nickolay Brustovetsky The Role of Adenine Nucleotide Translocase in the Mitochondrial Permeability Transition Cells calcium permeability transition pore adenine nucleotide translocase cyclophilin D F<sub>0</sub>F<sub>1</sub>-ATP synthase |
| title | The Role of Adenine Nucleotide Translocase in the Mitochondrial Permeability Transition |
| title_full | The Role of Adenine Nucleotide Translocase in the Mitochondrial Permeability Transition |
| title_fullStr | The Role of Adenine Nucleotide Translocase in the Mitochondrial Permeability Transition |
| title_full_unstemmed | The Role of Adenine Nucleotide Translocase in the Mitochondrial Permeability Transition |
| title_short | The Role of Adenine Nucleotide Translocase in the Mitochondrial Permeability Transition |
| title_sort | role of adenine nucleotide translocase in the mitochondrial permeability transition |
| topic | calcium permeability transition pore adenine nucleotide translocase cyclophilin D F<sub>0</sub>F<sub>1</sub>-ATP synthase |
| url | https://www.mdpi.com/2073-4409/9/12/2686 |
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