Pain as a risk factor of depression and anxiety symptoms with multiple myeloma during maintenance therapy
ObjectiveTo investigate the prevalence of depression or anxiety in patient with multiple myeloma (MM) in China during maintenance treatment and its associated influencing factors.MethodsPatients with MM (n = 160) received maintenance therapy, and control subjects (without MM, n = 160) matched on age...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-11-01
|
| Series: | Frontiers in Psychology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyg.2022.1015497/full |
| _version_ | 1811321170513887232 |
|---|---|
| author | Hui Shi Honglin Ren Ying Tian Zhe Chen Cuiping Xu Lu Lu Xiaoyu Ma Xiaoyan Li Wenming Chen Tong Guo Cuizhen Fan Wen Gao |
| author_facet | Hui Shi Honglin Ren Ying Tian Zhe Chen Cuiping Xu Lu Lu Xiaoyu Ma Xiaoyan Li Wenming Chen Tong Guo Cuizhen Fan Wen Gao |
| author_sort | Hui Shi |
| collection | DOAJ |
| description | ObjectiveTo investigate the prevalence of depression or anxiety in patient with multiple myeloma (MM) in China during maintenance treatment and its associated influencing factors.MethodsPatients with MM (n = 160) received maintenance therapy, and control subjects (without MM, n = 160) matched on age, sex, and BMI were recruited. Patients completed questionnaires, including the Patient Health Questionnaire-9 (PHQ-9), the Generalized Anxiety Disorder 7-item Scale (GAD-7), and the Verbal Pain Rating Scale (VPRS). Data on the Clinical characteristics, biochemical indicators of de novo MM were from the database of the Hematology Department of Beijing Chao-yang Hospital. Multiple linear regression model analysis was used to compare the differences in PHQ-9 and GAD-7 scale scores between the control group and the case group after correction for relevant variables. Multiple logistic regression models were subsequently used to analyze the correlation between the presence or absence of anxiety and depression and clinical indicators in the MM groups.ResultsDepression symptoms was present in 33.33% and anxiety symptoms in 24.68% of first-episode MM in the maintenance phase of treatment, and depression symptoms in the index-corrected MM group was significantly different from that in the control group (t = 2.54, P < 0.05). Analyses of multiple logistic regressions: biochemical indicators and clinical typing were not significantly associated with anxiety and depression. Compared to the pain rating 1, the risk of depressive mood was greater in the case group with the pain rating 2 (OR = 2.38) and the pain rating ≥ 3 (OR = 4.32). The risk of anxiety was greater in the case group with the pain rating ≥ 3 than the pain rating 1 (OR = 2.89).ConclusionDespite being in clinical remission, depressive mood problems in patients with MM remain prominent. Clinicians should enhance mood assessment and management in patients with concomitant pain. |
| first_indexed | 2024-04-13T13:13:24Z |
| format | Article |
| id | doaj.art-d72d70dd9d844337bb177d52e97a9ba0 |
| institution | Directory Open Access Journal |
| issn | 1664-1078 |
| language | English |
| last_indexed | 2024-04-13T13:13:24Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychology |
| spelling | doaj.art-d72d70dd9d844337bb177d52e97a9ba02022-12-22T02:45:33ZengFrontiers Media S.A.Frontiers in Psychology1664-10782022-11-011310.3389/fpsyg.2022.10154971015497Pain as a risk factor of depression and anxiety symptoms with multiple myeloma during maintenance therapyHui Shi0Honglin Ren1Ying Tian2Zhe Chen3Cuiping Xu4Lu Lu5Xiaoyu Ma6Xiaoyan Li7Wenming Chen8Tong Guo9Cuizhen Fan10Wen Gao11Department of Clinical Psychology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, ChinaDepartment of General Education, Wuhan Vocational College of Software and Engineering, Wuhan, ChinaDepartment of Hematology, Myeloma Research Center of Beijing, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, ChinaDepartment of Endocrinology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, ChinaDepartment of Respiratory and Critical Care Medicine, Beijing Bo-Ai Hospital, China Rehabilitation Research Center, Beijing, ChinaDepartment of Cardiology, Beijing Huai-Rou Hospital, Beijing, ChinaClinical Laboratory, Tai-Yang-Gong Community Health Service Center, Beijing, ChinaDepartment of Hematology, Bayannaoer Hospital, Inner Mongolia, ChinaDepartment of Hematology, Myeloma Research Center of Beijing, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, ChinaThe National Clinical Research Center for Mental Disorders and Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Beijing, China0Department of Oncology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, ChinaDepartment of Hematology, Myeloma Research Center of Beijing, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, ChinaObjectiveTo investigate the prevalence of depression or anxiety in patient with multiple myeloma (MM) in China during maintenance treatment and its associated influencing factors.MethodsPatients with MM (n = 160) received maintenance therapy, and control subjects (without MM, n = 160) matched on age, sex, and BMI were recruited. Patients completed questionnaires, including the Patient Health Questionnaire-9 (PHQ-9), the Generalized Anxiety Disorder 7-item Scale (GAD-7), and the Verbal Pain Rating Scale (VPRS). Data on the Clinical characteristics, biochemical indicators of de novo MM were from the database of the Hematology Department of Beijing Chao-yang Hospital. Multiple linear regression model analysis was used to compare the differences in PHQ-9 and GAD-7 scale scores between the control group and the case group after correction for relevant variables. Multiple logistic regression models were subsequently used to analyze the correlation between the presence or absence of anxiety and depression and clinical indicators in the MM groups.ResultsDepression symptoms was present in 33.33% and anxiety symptoms in 24.68% of first-episode MM in the maintenance phase of treatment, and depression symptoms in the index-corrected MM group was significantly different from that in the control group (t = 2.54, P < 0.05). Analyses of multiple logistic regressions: biochemical indicators and clinical typing were not significantly associated with anxiety and depression. Compared to the pain rating 1, the risk of depressive mood was greater in the case group with the pain rating 2 (OR = 2.38) and the pain rating ≥ 3 (OR = 4.32). The risk of anxiety was greater in the case group with the pain rating ≥ 3 than the pain rating 1 (OR = 2.89).ConclusionDespite being in clinical remission, depressive mood problems in patients with MM remain prominent. Clinicians should enhance mood assessment and management in patients with concomitant pain.https://www.frontiersin.org/articles/10.3389/fpsyg.2022.1015497/fullmyelomadepressionanxiety disordersmood disorderscancer pain |
| spellingShingle | Hui Shi Honglin Ren Ying Tian Zhe Chen Cuiping Xu Lu Lu Xiaoyu Ma Xiaoyan Li Wenming Chen Tong Guo Cuizhen Fan Wen Gao Pain as a risk factor of depression and anxiety symptoms with multiple myeloma during maintenance therapy Frontiers in Psychology myeloma depression anxiety disorders mood disorders cancer pain |
| title | Pain as a risk factor of depression and anxiety symptoms with multiple myeloma during maintenance therapy |
| title_full | Pain as a risk factor of depression and anxiety symptoms with multiple myeloma during maintenance therapy |
| title_fullStr | Pain as a risk factor of depression and anxiety symptoms with multiple myeloma during maintenance therapy |
| title_full_unstemmed | Pain as a risk factor of depression and anxiety symptoms with multiple myeloma during maintenance therapy |
| title_short | Pain as a risk factor of depression and anxiety symptoms with multiple myeloma during maintenance therapy |
| title_sort | pain as a risk factor of depression and anxiety symptoms with multiple myeloma during maintenance therapy |
| topic | myeloma depression anxiety disorders mood disorders cancer pain |
| url | https://www.frontiersin.org/articles/10.3389/fpsyg.2022.1015497/full |
| work_keys_str_mv | AT huishi painasariskfactorofdepressionandanxietysymptomswithmultiplemyelomaduringmaintenancetherapy AT honglinren painasariskfactorofdepressionandanxietysymptomswithmultiplemyelomaduringmaintenancetherapy AT yingtian painasariskfactorofdepressionandanxietysymptomswithmultiplemyelomaduringmaintenancetherapy AT zhechen painasariskfactorofdepressionandanxietysymptomswithmultiplemyelomaduringmaintenancetherapy AT cuipingxu painasariskfactorofdepressionandanxietysymptomswithmultiplemyelomaduringmaintenancetherapy AT lulu painasariskfactorofdepressionandanxietysymptomswithmultiplemyelomaduringmaintenancetherapy AT xiaoyuma painasariskfactorofdepressionandanxietysymptomswithmultiplemyelomaduringmaintenancetherapy AT xiaoyanli painasariskfactorofdepressionandanxietysymptomswithmultiplemyelomaduringmaintenancetherapy AT wenmingchen painasariskfactorofdepressionandanxietysymptomswithmultiplemyelomaduringmaintenancetherapy AT tongguo painasariskfactorofdepressionandanxietysymptomswithmultiplemyelomaduringmaintenancetherapy AT cuizhenfan painasariskfactorofdepressionandanxietysymptomswithmultiplemyelomaduringmaintenancetherapy AT wengao painasariskfactorofdepressionandanxietysymptomswithmultiplemyelomaduringmaintenancetherapy |