Puerarin alleviated oxidative stress and ferroptosis during renal fibrosis induced by ischemia/reperfusion injury via TLR4/Nox4 pathway in rats

Puerarin alleviated oxidative stress and ferroptosis during renal fibrosis induced by ischemia/reperfusion injury via TLR4/Nox4 pathway in rats

ABSTRACT Purpose: To investigate the role of puerarin on renal fibrosis and the underlying mechanism in renal ischemia and reperfusion (I/R) model. Methods: Rats were intraperitoneally injected with puerarin (50 or 100 mg/kg) per day for one week before renal I/R. The level of renal collagen depos...

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Bibliographic Details
Main Authors: Jun Jian, Dan Wang, Yufeng Xiong, Jingsong Wang, Qingyuan Zheng, Zhengyu Jiang, Jiacheng Zhong, Song Yang, Lei Wang
Format: Article
Language:English
Published: Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia 2023-08-01
Series:Acta Cirúrgica Brasileira
Subjects:
Chronic Kidney Disease
Ferroptosis
Reperfusion Injury
Oxidative Stress
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502023000100219&tlng=en

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