Hepatic Lipid Catabolism via PPARα-Lysosomal Crosstalk
Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors which belong to the nuclear hormone receptor superfamily. They regulate key aspects of energy metabolism within cells. Recently, PPARα has been implicated in the regulation of autophagy-lysosomal function,...
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| Format: | Article |
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MDPI AG
2020-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/7/2391 |
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| author | Rohit A. Sinha Sangam Rajak Brijesh K. Singh Paul M. Yen |
| author_facet | Rohit A. Sinha Sangam Rajak Brijesh K. Singh Paul M. Yen |
| author_sort | Rohit A. Sinha |
| collection | DOAJ |
| description | Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors which belong to the nuclear hormone receptor superfamily. They regulate key aspects of energy metabolism within cells. Recently, PPARα has been implicated in the regulation of autophagy-lysosomal function, which plays a key role in cellular energy metabolism. PPARα transcriptionally upregulates several genes involved in the autophagy-lysosomal degradative pathway that participates in lipolysis of triglycerides within the hepatocytes. Interestingly, a reciprocal regulation of PPARα nuclear action by autophagy-lysosomal activity also exists with implications in lipid metabolism. This review succinctly discusses the unique relationship between PPARα nuclear action and lysosomal activity and explores its impact on hepatic lipid homeostasis under pathological conditions such as non-alcoholic fatty liver disease (NAFLD). |
| first_indexed | 2024-03-09T06:18:12Z |
| format | Article |
| id | doaj.art-d733bccc43644092b922d7e34b3df78a |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T06:18:12Z |
| publishDate | 2020-03-01 |
| publisher | MDPI AG |
| record_format | Article |
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| spelling | doaj.art-d733bccc43644092b922d7e34b3df78a2023-12-03T11:50:51ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-03-01217239110.3390/ijms21072391Hepatic Lipid Catabolism via PPARα-Lysosomal CrosstalkRohit A. Sinha0Sangam Rajak1Brijesh K. Singh2Paul M. Yen3Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, IndiaDepartment of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, IndiaProgram of Cardiovascular and Metabolic Disorders, Duke-NUS Medical School, 8 College Road, Singapore 169587, SingaporeProgram of Cardiovascular and Metabolic Disorders, Duke-NUS Medical School, 8 College Road, Singapore 169587, SingaporePeroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors which belong to the nuclear hormone receptor superfamily. They regulate key aspects of energy metabolism within cells. Recently, PPARα has been implicated in the regulation of autophagy-lysosomal function, which plays a key role in cellular energy metabolism. PPARα transcriptionally upregulates several genes involved in the autophagy-lysosomal degradative pathway that participates in lipolysis of triglycerides within the hepatocytes. Interestingly, a reciprocal regulation of PPARα nuclear action by autophagy-lysosomal activity also exists with implications in lipid metabolism. This review succinctly discusses the unique relationship between PPARα nuclear action and lysosomal activity and explores its impact on hepatic lipid homeostasis under pathological conditions such as non-alcoholic fatty liver disease (NAFLD).https://www.mdpi.com/1422-0067/21/7/2391PPARslysosomesNCoR1PGC1αlipophagyperoxisomes |
| spellingShingle | Rohit A. Sinha Sangam Rajak Brijesh K. Singh Paul M. Yen Hepatic Lipid Catabolism via PPARα-Lysosomal Crosstalk International Journal of Molecular Sciences PPARs lysosomes NCoR1 PGC1α lipophagy peroxisomes |
| title | Hepatic Lipid Catabolism via PPARα-Lysosomal Crosstalk |
| title_full | Hepatic Lipid Catabolism via PPARα-Lysosomal Crosstalk |
| title_fullStr | Hepatic Lipid Catabolism via PPARα-Lysosomal Crosstalk |
| title_full_unstemmed | Hepatic Lipid Catabolism via PPARα-Lysosomal Crosstalk |
| title_short | Hepatic Lipid Catabolism via PPARα-Lysosomal Crosstalk |
| title_sort | hepatic lipid catabolism via pparα lysosomal crosstalk |
| topic | PPARs lysosomes NCoR1 PGC1α lipophagy peroxisomes |
| url | https://www.mdpi.com/1422-0067/21/7/2391 |
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