Carcinosarcoma of Breast with Hormone Receptor and Her2/neu Positivity
Carcinosarcoma is an extremely rare tumor of the breast comprising of two distinct cell lines i.e. the epithelial and mesenchymal. It is a highly aggressive tumor with a poor prognosis compared to other breast cancers with a reported incidence of less than 1% of all the breast cancers. A 35 year...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Pvt. Ltd.
2016-01-01
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| Series: | National Journal of Laboratory Medicine |
| Subjects: | |
| Online Access: | http://www.njlm.net/articles/PDF/2092/7-13279_F(AK)_PF1(VSUAK)_PFA(AK)_PF2(PVSU).pdf |
| Summary: | Carcinosarcoma is an extremely rare tumor of the breast
comprising of two distinct cell lines i.e. the epithelial and
mesenchymal. It is a highly aggressive tumor with a poor
prognosis compared to other breast cancers with a reported
incidence of less than 1% of all the breast cancers. A 35 year
old female presented to surgical outpatient with a fungating
mass in the right breast where cytological analysis from the
affected areas revealed spindle cells of malignant potential.
A modified radical mastectomy was performed and following
histopathological examination of the excised tissue, a final
diagnosis of carcinosarcoma of breast was concluded.
Immunological staining done showed a negative staining for
PR and positive staining for ER, Her-2/neu and CK receptors,
as against the conventional triple negative staining pattern.
Along with a rare staining pattern of this rare tumor reported in
literature, this case merits presentation owing to its diagnostic
and therapeutic challenges. |
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| ISSN: | 2277-8551 2455-6882 |