Carcinosarcoma of Breast with Hormone Receptor and Her2/neu Positivity
Carcinosarcoma is an extremely rare tumor of the breast comprising of two distinct cell lines i.e. the epithelial and mesenchymal. It is a highly aggressive tumor with a poor prognosis compared to other breast cancers with a reported incidence of less than 1% of all the breast cancers. A 35 year...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Pvt. Ltd.
2016-01-01
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| Series: | National Journal of Laboratory Medicine |
| Subjects: | |
| Online Access: | http://www.njlm.net/articles/PDF/2092/7-13279_F(AK)_PF1(VSUAK)_PFA(AK)_PF2(PVSU).pdf |
| _version_ | 1811248041019047936 |
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| author | Deepti Agarwal Vijay Malik Ruchi Agarwa M.K. Garg Shilpa Garg |
| author_facet | Deepti Agarwal Vijay Malik Ruchi Agarwa M.K. Garg Shilpa Garg |
| author_sort | Deepti Agarwal |
| collection | DOAJ |
| description | Carcinosarcoma is an extremely rare tumor of the breast
comprising of two distinct cell lines i.e. the epithelial and
mesenchymal. It is a highly aggressive tumor with a poor
prognosis compared to other breast cancers with a reported
incidence of less than 1% of all the breast cancers. A 35 year
old female presented to surgical outpatient with a fungating
mass in the right breast where cytological analysis from the
affected areas revealed spindle cells of malignant potential.
A modified radical mastectomy was performed and following
histopathological examination of the excised tissue, a final
diagnosis of carcinosarcoma of breast was concluded.
Immunological staining done showed a negative staining for
PR and positive staining for ER, Her-2/neu and CK receptors,
as against the conventional triple negative staining pattern.
Along with a rare staining pattern of this rare tumor reported in
literature, this case merits presentation owing to its diagnostic
and therapeutic challenges. |
| first_indexed | 2024-04-12T15:20:01Z |
| format | Article |
| id | doaj.art-d735a8962fdb47ccb3cd9eb5b162ed2c |
| institution | Directory Open Access Journal |
| issn | 2277-8551 2455-6882 |
| language | English |
| last_indexed | 2024-04-12T15:20:01Z |
| publishDate | 2016-01-01 |
| publisher | JCDR Research and Publications Pvt. Ltd. |
| record_format | Article |
| series | National Journal of Laboratory Medicine |
| spelling | doaj.art-d735a8962fdb47ccb3cd9eb5b162ed2c2022-12-22T03:27:30ZengJCDR Research and Publications Pvt. Ltd.National Journal of Laboratory Medicine2277-85512455-68822016-01-0151262910.7860/NJLM/2016/13279:2092Carcinosarcoma of Breast with Hormone Receptor and Her2/neu PositivityDeepti Agarwal 0Vijay Malik1Ruchi Agarwa2M.K. Garg3 Shilpa Garg4Associate Professor, Department of Pathology, BPS Govt. Medical College for Women, Khanpur Kalan, Sonipat, Haryana, India.Assistant Professor, Department of Surgery, BPS Govt. Medical College for Women, Khanpur Kalan, Sonipat, Haryana, India.Assistant Professor, Department of Pathology, BPS Govt. Medical College for Women, Khanpur Kalan, Sonipat, Haryana, India.Professor and Head of Department, Department of Surgery, BPS Govt. Medical College for Women, Khanpur Kalan, Sonipat, Haryana, India.Assistant Professor, Department of Pathology, Pt. BD Sharma PGIMS Rohtak, Haryana, India.Carcinosarcoma is an extremely rare tumor of the breast comprising of two distinct cell lines i.e. the epithelial and mesenchymal. It is a highly aggressive tumor with a poor prognosis compared to other breast cancers with a reported incidence of less than 1% of all the breast cancers. A 35 year old female presented to surgical outpatient with a fungating mass in the right breast where cytological analysis from the affected areas revealed spindle cells of malignant potential. A modified radical mastectomy was performed and following histopathological examination of the excised tissue, a final diagnosis of carcinosarcoma of breast was concluded. Immunological staining done showed a negative staining for PR and positive staining for ER, Her-2/neu and CK receptors, as against the conventional triple negative staining pattern. Along with a rare staining pattern of this rare tumor reported in literature, this case merits presentation owing to its diagnostic and therapeutic challenges.http://www.njlm.net/articles/PDF/2092/7-13279_F(AK)_PF1(VSUAK)_PFA(AK)_PF2(PVSU).pdfanti-cytokeratinmetaplastic breast carcinomas (mbc)vimentin |
| spellingShingle | Deepti Agarwal Vijay Malik Ruchi Agarwa M.K. Garg Shilpa Garg Carcinosarcoma of Breast with Hormone Receptor and Her2/neu Positivity National Journal of Laboratory Medicine anti-cytokeratin metaplastic breast carcinomas (mbc) vimentin |
| title | Carcinosarcoma of Breast with Hormone Receptor and Her2/neu Positivity |
| title_full | Carcinosarcoma of Breast with Hormone Receptor and Her2/neu Positivity |
| title_fullStr | Carcinosarcoma of Breast with Hormone Receptor and Her2/neu Positivity |
| title_full_unstemmed | Carcinosarcoma of Breast with Hormone Receptor and Her2/neu Positivity |
| title_short | Carcinosarcoma of Breast with Hormone Receptor and Her2/neu Positivity |
| title_sort | carcinosarcoma of breast with hormone receptor and her2 neu positivity |
| topic | anti-cytokeratin metaplastic breast carcinomas (mbc) vimentin |
| url | http://www.njlm.net/articles/PDF/2092/7-13279_F(AK)_PF1(VSUAK)_PFA(AK)_PF2(PVSU).pdf |
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