EVALUATION OF ROLE OF HER2 EXPRESSION BY IHC IN PREMALIGNANT AND MALIGNANT LESIONS OF THE UTERINE CERVIX – AN INSTITUTIONAL BASED PROSPECTIVE STUDY.
Background: The most frequent malignancy in Indian women is uterine cervix cancer. According to the clinical stage of the tumour and the surgical findings, surgery is the primary mode of treatment, coupled with radiation and chemotherapy. Despite the use of cisplatin-based combination treatment,...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Student's Journal of Health Research
2023-06-01
|
| Series: | Student's Journal of Health Research Africa |
| Subjects: | |
| Online Access: | https://sjhresearchafrica.org/index.php/public-html/article/view/491 |
| _version_ | 1797791339991007232 |
|---|---|
| author | Mitali Dash Anushuya Dash Bandana Mishra Saroj Ranjan Mohanty Manoj Kumar Patro Sunita Rani Senapati |
| author_facet | Mitali Dash Anushuya Dash Bandana Mishra Saroj Ranjan Mohanty Manoj Kumar Patro Sunita Rani Senapati |
| author_sort | Mitali Dash |
| collection | DOAJ |
| description |
Background:
The most frequent malignancy in Indian women is uterine cervix cancer. According to the clinical stage of the tumour and the surgical findings, surgery is the primary mode of treatment, coupled with radiation and chemotherapy. Despite the use of cisplatin-based combination treatment, patients with advanced or recurring illness have a poor prognosis. In order to replace or supplement the present therapy for these patients, it is becoming more and more important to identify novel therapeutic targets. The goal of the current investigation was to determine whether Her-2/neu expression was present.
Methods:
In this investigation, 81 cervical specimens were used. These cases included squamous cell carcinoma and adenocarcinoma diagnoses. BioGenex monoclonal mouse anti-human HER-2/neu Receptor IgG1 antibody was used for HER-2/neu immunostaining.
Results:
Malignant lesions showed higher expression of HER-2/neu compared to premalignant lesions. Additionally, there was a correlation between staining intensity and lymph node metastasis, clinical stage, and malignant tumour grade.
Conclusion:
Oncoprotein HER-2/neu overexpression has been linked to aggressive biological behaviour, a poor prognosis, and the propensity for metastatic spread.
|
| first_indexed | 2024-03-13T02:17:24Z |
| format | Article |
| id | doaj.art-d735d963bbba4d069795d1de2b28de0d |
| institution | Directory Open Access Journal |
| issn | 2709-9997 |
| language | English |
| last_indexed | 2024-03-13T02:17:24Z |
| publishDate | 2023-06-01 |
| publisher | Student's Journal of Health Research |
| record_format | Article |
| series | Student's Journal of Health Research Africa |
| spelling | doaj.art-d735d963bbba4d069795d1de2b28de0d2023-06-30T11:43:18ZengStudent's Journal of Health ResearchStudent's Journal of Health Research Africa2709-99972023-06-014610.51168/sjhrafrica.v4i6.491EVALUATION OF ROLE OF HER2 EXPRESSION BY IHC IN PREMALIGNANT AND MALIGNANT LESIONS OF THE UTERINE CERVIX – AN INSTITUTIONAL BASED PROSPECTIVE STUDY.Mitali Dash0Anushuya Dash1Bandana Mishra2 Saroj Ranjan Mohanty3Manoj Kumar Patro4Sunita Rani Senapati5Department of Pathology, MKCG Medical College and Hospital, Brahmapur, Odisha.BB MCH, BalangirFM MCH, Baleshwar.MKCG MCH Brahmapur.Department of Pathology, MKCG Medical College and Hospital, Brahmapur, Odisha.MKCG MCH Brahmapur. Background: The most frequent malignancy in Indian women is uterine cervix cancer. According to the clinical stage of the tumour and the surgical findings, surgery is the primary mode of treatment, coupled with radiation and chemotherapy. Despite the use of cisplatin-based combination treatment, patients with advanced or recurring illness have a poor prognosis. In order to replace or supplement the present therapy for these patients, it is becoming more and more important to identify novel therapeutic targets. The goal of the current investigation was to determine whether Her-2/neu expression was present. Methods: In this investigation, 81 cervical specimens were used. These cases included squamous cell carcinoma and adenocarcinoma diagnoses. BioGenex monoclonal mouse anti-human HER-2/neu Receptor IgG1 antibody was used for HER-2/neu immunostaining. Results: Malignant lesions showed higher expression of HER-2/neu compared to premalignant lesions. Additionally, there was a correlation between staining intensity and lymph node metastasis, clinical stage, and malignant tumour grade. Conclusion: Oncoprotein HER-2/neu overexpression has been linked to aggressive biological behaviour, a poor prognosis, and the propensity for metastatic spread. https://sjhresearchafrica.org/index.php/public-html/article/view/491Cervical carcinomaImmunohistochemistryOncoproteinOverexpression |
| spellingShingle | Mitali Dash Anushuya Dash Bandana Mishra Saroj Ranjan Mohanty Manoj Kumar Patro Sunita Rani Senapati EVALUATION OF ROLE OF HER2 EXPRESSION BY IHC IN PREMALIGNANT AND MALIGNANT LESIONS OF THE UTERINE CERVIX – AN INSTITUTIONAL BASED PROSPECTIVE STUDY. Student's Journal of Health Research Africa Cervical carcinoma Immunohistochemistry Oncoprotein Overexpression |
| title | EVALUATION OF ROLE OF HER2 EXPRESSION BY IHC IN PREMALIGNANT AND MALIGNANT LESIONS OF THE UTERINE CERVIX – AN INSTITUTIONAL BASED PROSPECTIVE STUDY. |
| title_full | EVALUATION OF ROLE OF HER2 EXPRESSION BY IHC IN PREMALIGNANT AND MALIGNANT LESIONS OF THE UTERINE CERVIX – AN INSTITUTIONAL BASED PROSPECTIVE STUDY. |
| title_fullStr | EVALUATION OF ROLE OF HER2 EXPRESSION BY IHC IN PREMALIGNANT AND MALIGNANT LESIONS OF THE UTERINE CERVIX – AN INSTITUTIONAL BASED PROSPECTIVE STUDY. |
| title_full_unstemmed | EVALUATION OF ROLE OF HER2 EXPRESSION BY IHC IN PREMALIGNANT AND MALIGNANT LESIONS OF THE UTERINE CERVIX – AN INSTITUTIONAL BASED PROSPECTIVE STUDY. |
| title_short | EVALUATION OF ROLE OF HER2 EXPRESSION BY IHC IN PREMALIGNANT AND MALIGNANT LESIONS OF THE UTERINE CERVIX – AN INSTITUTIONAL BASED PROSPECTIVE STUDY. |
| title_sort | evaluation of role of her2 expression by ihc in premalignant and malignant lesions of the uterine cervix an institutional based prospective study |
| topic | Cervical carcinoma Immunohistochemistry Oncoprotein Overexpression |
| url | https://sjhresearchafrica.org/index.php/public-html/article/view/491 |
| work_keys_str_mv | AT mitalidash evaluationofroleofher2expressionbyihcinpremalignantandmalignantlesionsoftheuterinecervixaninstitutionalbasedprospectivestudy AT anushuyadash evaluationofroleofher2expressionbyihcinpremalignantandmalignantlesionsoftheuterinecervixaninstitutionalbasedprospectivestudy AT bandanamishra evaluationofroleofher2expressionbyihcinpremalignantandmalignantlesionsoftheuterinecervixaninstitutionalbasedprospectivestudy AT sarojranjanmohanty evaluationofroleofher2expressionbyihcinpremalignantandmalignantlesionsoftheuterinecervixaninstitutionalbasedprospectivestudy AT manojkumarpatro evaluationofroleofher2expressionbyihcinpremalignantandmalignantlesionsoftheuterinecervixaninstitutionalbasedprospectivestudy AT sunitaranisenapati evaluationofroleofher2expressionbyihcinpremalignantandmalignantlesionsoftheuterinecervixaninstitutionalbasedprospectivestudy |