Preparation and properties of poly(hydroxyethyl methacrylate) glycerol gel as biomimetic cartilage replacement material
According to the material research that human articular cartilage is expected to be repaired after injury, a new artificial cartilage-like material was prepared by thermal polymerization in this experiment. Under water bath insulation and initiator conditions, hydroxyethyl methacrylate(CH<sub>...
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| Format: | Article |
| Language: | zho |
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Journal of Materials Engineering
2019-07-01
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| Series: | Cailiao gongcheng |
| Subjects: | |
| Online Access: | http://jme.biam.ac.cn/CN/Y2019/V47/I7/71 |
| _version_ | 1797965012088651776 |
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| author | WANG Dan TAO De-hua HUANG Xiu-ling HUA Zi-kai |
| author_facet | WANG Dan TAO De-hua HUANG Xiu-ling HUA Zi-kai |
| author_sort | WANG Dan |
| collection | DOAJ |
| description | According to the material research that human articular cartilage is expected to be repaired after injury, a new artificial cartilage-like material was prepared by thermal polymerization in this experiment. Under water bath insulation and initiator conditions, hydroxyethyl methacrylate(CH<sub>2</sub> CCH<sub>3</sub>COOCH<sub>2</sub>CH<sub>2</sub>OH,HEMA) and medical glycerol(C<sub>3</sub>H<sub>8</sub>O<sub>3</sub>) were polymerized into a new gel. And the surface morphology was compared with that of porcine cartilage, and the mechanical properties such as compressive strength and elasticity were tested. By analyzing and characterizing with FTIR spectra, the host of gel is still PHEMA, and glycerol exists in gel phase. The hardness of gel decreases with the increase of glycerol ratio, while the surface roughness of gel increases. When the mass ratio of HEMA to glycerol is 1:1-1:3, the hardness of the gel is close to that of pig cartilage, and the surface is smooth under the conditions of 1:1 and 1:2. Gels of four mass ratios have good compressive strength and elasticity. When the mass ratio is 1:1, the compressive properties and comprehensive properties are the best. The experimental results indicate that PHEMA and glycerol gel polymers have good mechanical properties as artificial cartilage materials, they may provide further investigation for clinical trials. |
| first_indexed | 2024-04-11T01:52:28Z |
| format | Article |
| id | doaj.art-d736270911d44d4984c277cab321309e |
| institution | Directory Open Access Journal |
| issn | 1001-4381 1001-4381 |
| language | zho |
| last_indexed | 2024-04-11T01:52:28Z |
| publishDate | 2019-07-01 |
| publisher | Journal of Materials Engineering |
| record_format | Article |
| series | Cailiao gongcheng |
| spelling | doaj.art-d736270911d44d4984c277cab321309e2023-01-03T06:08:14ZzhoJournal of Materials EngineeringCailiao gongcheng1001-43811001-43812019-07-01477717510.11868/j.issn.1001-4381.2019.000101201907000101Preparation and properties of poly(hydroxyethyl methacrylate) glycerol gel as biomimetic cartilage replacement materialWANG Dan0TAO De-hua1HUANG Xiu-ling2HUA Zi-kai3School of Mechatronic Engineering and Automation, Shanghai University, Shanghai 200072, ChinaSchool of Mechatronic Engineering and Automation, Shanghai University, Shanghai 200072, ChinaSchool of Mechatronic Engineering and Automation, Shanghai University, Shanghai 200072, ChinaSchool of Mechatronic Engineering and Automation, Shanghai University, Shanghai 200072, ChinaAccording to the material research that human articular cartilage is expected to be repaired after injury, a new artificial cartilage-like material was prepared by thermal polymerization in this experiment. Under water bath insulation and initiator conditions, hydroxyethyl methacrylate(CH<sub>2</sub> CCH<sub>3</sub>COOCH<sub>2</sub>CH<sub>2</sub>OH,HEMA) and medical glycerol(C<sub>3</sub>H<sub>8</sub>O<sub>3</sub>) were polymerized into a new gel. And the surface morphology was compared with that of porcine cartilage, and the mechanical properties such as compressive strength and elasticity were tested. By analyzing and characterizing with FTIR spectra, the host of gel is still PHEMA, and glycerol exists in gel phase. The hardness of gel decreases with the increase of glycerol ratio, while the surface roughness of gel increases. When the mass ratio of HEMA to glycerol is 1:1-1:3, the hardness of the gel is close to that of pig cartilage, and the surface is smooth under the conditions of 1:1 and 1:2. Gels of four mass ratios have good compressive strength and elasticity. When the mass ratio is 1:1, the compressive properties and comprehensive properties are the best. The experimental results indicate that PHEMA and glycerol gel polymers have good mechanical properties as artificial cartilage materials, they may provide further investigation for clinical trials.http://jme.biam.ac.cn/CN/Y2019/V47/I7/71poly(hydroxyethyl methacrylate)glycerolgelartificial cartilagemechanical property |
| spellingShingle | WANG Dan TAO De-hua HUANG Xiu-ling HUA Zi-kai Preparation and properties of poly(hydroxyethyl methacrylate) glycerol gel as biomimetic cartilage replacement material Cailiao gongcheng poly(hydroxyethyl methacrylate) glycerol gel artificial cartilage mechanical property |
| title | Preparation and properties of poly(hydroxyethyl methacrylate) glycerol gel as biomimetic cartilage replacement material |
| title_full | Preparation and properties of poly(hydroxyethyl methacrylate) glycerol gel as biomimetic cartilage replacement material |
| title_fullStr | Preparation and properties of poly(hydroxyethyl methacrylate) glycerol gel as biomimetic cartilage replacement material |
| title_full_unstemmed | Preparation and properties of poly(hydroxyethyl methacrylate) glycerol gel as biomimetic cartilage replacement material |
| title_short | Preparation and properties of poly(hydroxyethyl methacrylate) glycerol gel as biomimetic cartilage replacement material |
| title_sort | preparation and properties of poly hydroxyethyl methacrylate glycerol gel as biomimetic cartilage replacement material |
| topic | poly(hydroxyethyl methacrylate) glycerol gel artificial cartilage mechanical property |
| url | http://jme.biam.ac.cn/CN/Y2019/V47/I7/71 |
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