Three-dimensional culture of MSCs produces exosomes with improved yield and enhanced therapeutic efficacy for cisplatin-induced acute kidney injury

Three-dimensional culture of MSCs produces exosomes with improved yield and enhanced therapeutic efficacy for cisplatin-induced acute kidney injury

Abstract Background Exosomes derived from mesenchymal stem cells (MSC-exos) have been demonstrated with great potential in the treatment of multiple human diseases including acute kidney injury (AKI) by virtue of their intrinsic cargoes. However, there are major challenges of low yield and the lack...

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Bibliographic Details
Main Authors: Jingyuan Cao, Bin Wang, Taotao Tang, Linli Lv, Zhaoying Ding, Zuolin Li, Ruoyu Hu, Qing Wei, Anran Shen, Yuqi Fu, Bicheng Liu
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Stem Cell Research & Therapy
Subjects:
Exosomes
Mesenchymal stem cell
Three-dimensional culture
Acute kidney injury
Online Access:http://link.springer.com/article/10.1186/s13287-020-01719-2

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