The impact of phyto- and endo-cannabinoids on central nervous system diseases：A review
Background and aim: Cannabis sativa L. is a medicinal plant with a long history. Phyto-cannabinoids are a class of compounds from C. sativa L. with varieties of structures. Endocannabinoids exist in the human body. This article provides an overview of natural cannabinoids (phyto-cannabinoids and end...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Journal of Traditional and Complementary Medicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2225411022000761 |
| _version_ | 1797955450850770944 |
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| author | Shan-Shan Zhang Niu-Niu Zhang Tian-Tian Guo Lee-Yan Sheen Chi-Tang Ho Nai-Sheng Bai |
| author_facet | Shan-Shan Zhang Niu-Niu Zhang Tian-Tian Guo Lee-Yan Sheen Chi-Tang Ho Nai-Sheng Bai |
| author_sort | Shan-Shan Zhang |
| collection | DOAJ |
| description | Background and aim: Cannabis sativa L. is a medicinal plant with a long history. Phyto-cannabinoids are a class of compounds from C. sativa L. with varieties of structures. Endocannabinoids exist in the human body. This article provides an overview of natural cannabinoids (phyto-cannabinoids and endocannabinoids) with an emphasis on their pharmacology activities. Experimental procedure: The keywords “Cannabis sativa L″, “cannabinoids”, and “central nervous system (CNS) diseases” were used for searching and collecting pieces of literature from PubMed, ScienceDirect, Web of Science, and Google Scholar. The data were extracted and analyzed to explore the effects of cannabinoids on CNS diseases. Result and conclusion: In this paper, schematic diagrams are used to intuitively show the phyto-cannabinoids skeletons’ mutual conversion and pharmacological activities, with special emphasis on their relevant pharmacological activities on central nervous system (CNS) diseases. It was found that the endocannabinoid system and microglia play a crucial role in the treatment of CNS diseases. In the past few years, pharmacological studies focused on Δ9-THC, CBD, and the endocannabinoids system. It is expected to encourage new studies on a more deep exploration of other types of cannabinoids and the mechanism of their pharmacological activities in the future. |
| first_indexed | 2024-04-10T23:33:21Z |
| format | Article |
| id | doaj.art-d738f6645d424ab5af29b80a6b6abeaa |
| institution | Directory Open Access Journal |
| issn | 2225-4110 |
| language | English |
| last_indexed | 2024-04-10T23:33:21Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Traditional and Complementary Medicine |
| spelling | doaj.art-d738f6645d424ab5af29b80a6b6abeaa2023-01-12T04:19:16ZengElsevierJournal of Traditional and Complementary Medicine2225-41102023-01-011313038The impact of phyto- and endo-cannabinoids on central nervous system diseases：A reviewShan-Shan Zhang0Niu-Niu Zhang1Tian-Tian Guo2Lee-Yan Sheen3Chi-Tang Ho4Nai-Sheng Bai5College of Chemical Engineering, Department of Pharmaceutical Engineering, Northwest University, 229 Taibai North Road, Xi'an, Shaanxi, 710069, China; College of Food Science and Technology, Northwest University, 229 Taibai North Road, Xi'an, Shaanxi, 710069, ChinaCollege of Food Science and Technology, Northwest University, 229 Taibai North Road, Xi'an, Shaanxi, 710069, ChinaCollege of Food Science and Technology, Northwest University, 229 Taibai North Road, Xi'an, Shaanxi, 710069, ChinaInstitute of Food Science and Technology, National Taiwan University, Taipei, TaiwanDepartment of Food Science, Rutgers University, 65 Dudley Road, New Brunswick, NJ, 08901, USA; Corresponding author.College of Food Science and Technology, Northwest University, 229 Taibai North Road, Xi'an, Shaanxi, 710069, China; Corresponding author.Background and aim: Cannabis sativa L. is a medicinal plant with a long history. Phyto-cannabinoids are a class of compounds from C. sativa L. with varieties of structures. Endocannabinoids exist in the human body. This article provides an overview of natural cannabinoids (phyto-cannabinoids and endocannabinoids) with an emphasis on their pharmacology activities. Experimental procedure: The keywords “Cannabis sativa L″, “cannabinoids”, and “central nervous system (CNS) diseases” were used for searching and collecting pieces of literature from PubMed, ScienceDirect, Web of Science, and Google Scholar. The data were extracted and analyzed to explore the effects of cannabinoids on CNS diseases. Result and conclusion: In this paper, schematic diagrams are used to intuitively show the phyto-cannabinoids skeletons’ mutual conversion and pharmacological activities, with special emphasis on their relevant pharmacological activities on central nervous system (CNS) diseases. It was found that the endocannabinoid system and microglia play a crucial role in the treatment of CNS diseases. In the past few years, pharmacological studies focused on Δ9-THC, CBD, and the endocannabinoids system. It is expected to encourage new studies on a more deep exploration of other types of cannabinoids and the mechanism of their pharmacological activities in the future.http://www.sciencedirect.com/science/article/pii/S2225411022000761CannabinoidsChemical structuresEndocannabinoid systemCNS diseases |
| spellingShingle | Shan-Shan Zhang Niu-Niu Zhang Tian-Tian Guo Lee-Yan Sheen Chi-Tang Ho Nai-Sheng Bai The impact of phyto- and endo-cannabinoids on central nervous system diseases：A review Journal of Traditional and Complementary Medicine Cannabinoids Chemical structures Endocannabinoid system CNS diseases |
| title | The impact of phyto- and endo-cannabinoids on central nervous system diseases：A review |
| title_full | The impact of phyto- and endo-cannabinoids on central nervous system diseases：A review |
| title_fullStr | The impact of phyto- and endo-cannabinoids on central nervous system diseases：A review |
| title_full_unstemmed | The impact of phyto- and endo-cannabinoids on central nervous system diseases：A review |
| title_short | The impact of phyto- and endo-cannabinoids on central nervous system diseases：A review |
| title_sort | impact of phyto and endo cannabinoids on central nervous system diseases a review |
| topic | Cannabinoids Chemical structures Endocannabinoid system CNS diseases |
| url | http://www.sciencedirect.com/science/article/pii/S2225411022000761 |
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