Hemolytic Activity, Cytotoxicity, and Antimicrobial Effects of Silver Nanoparticles Conjugated with Lincomycin or Cefazolin
The overuse of antibiotics has led to the emergence of resistant bacteria. A good alternative is silver nanoparticles, which have antibacterial activity against Gram-negative and Gram-positive bacteria, including multidrug-resistant strains. Their combination with already known antibiotics has a syn...
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MDPI AG
2022-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/22/13709 |
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| author | Dmitriy Korolev Michael Shumilo Galina Shulmeyster Alexander Krutikov Alexey Golovkin Alexander Mishanin Anna Spiridonova Olga Kulagina Michael Galagudza |
| author_facet | Dmitriy Korolev Michael Shumilo Galina Shulmeyster Alexander Krutikov Alexey Golovkin Alexander Mishanin Anna Spiridonova Olga Kulagina Michael Galagudza |
| author_sort | Dmitriy Korolev |
| collection | DOAJ |
| description | The overuse of antibiotics has led to the emergence of resistant bacteria. A good alternative is silver nanoparticles, which have antibacterial activity against Gram-negative and Gram-positive bacteria, including multidrug-resistant strains. Their combination with already known antibiotics has a synergistic effect. In this work, we studied the synthesis of conjugates of silver nanoparticles with two antibiotics, lincomycin and cefazolin. Albumin and glutathione were used as spacer shells with functional groups. The physicochemical properties of the obtained conjugates, their cytotoxicity and synergism of antimicrobial activity were studied. The 50% antimicrobial activity of the obtained samples was shown, which allows them to be recommended for use as topical drug preparations. |
| first_indexed | 2024-03-09T18:19:03Z |
| format | Article |
| id | doaj.art-d738fdd20f0a400aaa74f36a286f5044 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T18:19:03Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-d738fdd20f0a400aaa74f36a286f50442023-11-24T08:32:33ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-11-0123221370910.3390/ijms232213709Hemolytic Activity, Cytotoxicity, and Antimicrobial Effects of Silver Nanoparticles Conjugated with Lincomycin or CefazolinDmitriy Korolev0Michael Shumilo1Galina Shulmeyster2Alexander Krutikov3Alexey Golovkin4Alexander Mishanin5Anna Spiridonova6Olga Kulagina7Michael Galagudza8Institute of Experimental Medicine, Almazov National Research Centre, 197341 Saint-Petersburg, RussiaInstitute of Experimental Medicine, Almazov National Research Centre, 197341 Saint-Petersburg, RussiaInstitute of Experimental Medicine, Almazov National Research Centre, 197341 Saint-Petersburg, RussiaLaboratory of Infiltrative Heart Disease, Almazov National Research Centre, 197341 Saint-Petersburg, RussiaInstitution of Molecular Biology and Genetics, Almazov National Research Centre, 197341 Saint-Petersburg, RussiaInstitution of Molecular Biology and Genetics, Almazov National Research Centre, 197341 Saint-Petersburg, RussiaDepartment of Clinical Microbiology, Pavlov First Saint-Petersburg State Medical University, 197022 Saint-Petersburg, RussiaDepartment of Clinical Microbiology, Pavlov First Saint-Petersburg State Medical University, 197022 Saint-Petersburg, RussiaInstitute of Experimental Medicine, Almazov National Research Centre, 197341 Saint-Petersburg, RussiaThe overuse of antibiotics has led to the emergence of resistant bacteria. A good alternative is silver nanoparticles, which have antibacterial activity against Gram-negative and Gram-positive bacteria, including multidrug-resistant strains. Their combination with already known antibiotics has a synergistic effect. In this work, we studied the synthesis of conjugates of silver nanoparticles with two antibiotics, lincomycin and cefazolin. Albumin and glutathione were used as spacer shells with functional groups. The physicochemical properties of the obtained conjugates, their cytotoxicity and synergism of antimicrobial activity were studied. The 50% antimicrobial activity of the obtained samples was shown, which allows them to be recommended for use as topical drug preparations.https://www.mdpi.com/1422-0067/23/22/13709silver nanoparticleschemical synthesishemolysiscytotoxicityantimicrobial activityantibiotic |
| spellingShingle | Dmitriy Korolev Michael Shumilo Galina Shulmeyster Alexander Krutikov Alexey Golovkin Alexander Mishanin Anna Spiridonova Olga Kulagina Michael Galagudza Hemolytic Activity, Cytotoxicity, and Antimicrobial Effects of Silver Nanoparticles Conjugated with Lincomycin or Cefazolin International Journal of Molecular Sciences silver nanoparticles chemical synthesis hemolysis cytotoxicity antimicrobial activity antibiotic |
| title | Hemolytic Activity, Cytotoxicity, and Antimicrobial Effects of Silver Nanoparticles Conjugated with Lincomycin or Cefazolin |
| title_full | Hemolytic Activity, Cytotoxicity, and Antimicrobial Effects of Silver Nanoparticles Conjugated with Lincomycin or Cefazolin |
| title_fullStr | Hemolytic Activity, Cytotoxicity, and Antimicrobial Effects of Silver Nanoparticles Conjugated with Lincomycin or Cefazolin |
| title_full_unstemmed | Hemolytic Activity, Cytotoxicity, and Antimicrobial Effects of Silver Nanoparticles Conjugated with Lincomycin or Cefazolin |
| title_short | Hemolytic Activity, Cytotoxicity, and Antimicrobial Effects of Silver Nanoparticles Conjugated with Lincomycin or Cefazolin |
| title_sort | hemolytic activity cytotoxicity and antimicrobial effects of silver nanoparticles conjugated with lincomycin or cefazolin |
| topic | silver nanoparticles chemical synthesis hemolysis cytotoxicity antimicrobial activity antibiotic |
| url | https://www.mdpi.com/1422-0067/23/22/13709 |
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