Yeast as a system for modeling mitochondrial disease mechanisms and discovering therapies

Yeast as a system for modeling mitochondrial disease mechanisms and discovering therapies

Mitochondrial diseases are severe and largely untreatable. Owing to the many essential processes carried out by mitochondria and the complex cellular systems that support these processes, these diseases are diverse, pleiotropic, and challenging to study. Much of our current understanding of mitochon...

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Bibliographic Details
Main Authors: Jean-Paul Lasserre, Alain Dautant, Raeka S. Aiyar, Roza Kucharczyk, Annie Glatigny, Déborah Tribouillard-Tanvier, Joanna Rytka, Marc Blondel, Natalia Skoczen, Pascal Reynier, Laras Pitayu, Agnès Rötig, Agnès Delahodde, Lars M. Steinmetz, Geneviève Dujardin, Vincent Procaccio, Jean-Paul di Rago
Format: Article
Language:English
Published: The Company of Biologists 2015-06-01
Series:Disease Models & Mechanisms
Subjects:
OXPHOS
Drug screening
Genetic suppressors
Mitochondrial disease
Yeast
Online Access:http://dmm.biologists.org/content/8/6/509

Internet

http://dmm.biologists.org/content/8/6/509

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