<i>Piper</i> Species: A Comprehensive Review on Their Phytochemistry, Biological Activities and Applications
<i>Piper</i> species are aromatic plants used as spices in the kitchen, but their secondary metabolites have also shown biological effects on human health. These plants are rich in essential oils, which can be found in their fruits, seeds, leaves, branches, roots and stems. Some <i>...
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2019-04-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/24/7/1364 |
| _version_ | 1818335987125714944 |
|---|---|
| author | Bahare Salehi Zainul Amiruddin Zakaria Rabin Gyawali Salam A. Ibrahim Jovana Rajkovic Zabta Khan Shinwari Tariq Khan Javad Sharifi-Rad Adem Ozleyen Elif Turkdonmez Marco Valussi Tugba Boyunegmez Tumer Lianet Monzote Fidalgo Miquel Martorell William N. Setzer |
| author_facet | Bahare Salehi Zainul Amiruddin Zakaria Rabin Gyawali Salam A. Ibrahim Jovana Rajkovic Zabta Khan Shinwari Tariq Khan Javad Sharifi-Rad Adem Ozleyen Elif Turkdonmez Marco Valussi Tugba Boyunegmez Tumer Lianet Monzote Fidalgo Miquel Martorell William N. Setzer |
| author_sort | Bahare Salehi |
| collection | DOAJ |
| description | <i>Piper</i> species are aromatic plants used as spices in the kitchen, but their secondary metabolites have also shown biological effects on human health. These plants are rich in essential oils, which can be found in their fruits, seeds, leaves, branches, roots and stems. Some <i>Piper</i> species have simple chemical profiles, while others, such as <i>Piper nigrum</i>, <i>Piper betle</i>, and <i>Piper auritum</i>, contain very diverse suites of secondary metabolites. In traditional medicine, <i>Piper</i> species have been used worldwide to treat several diseases such as urological problems, skin, liver and stomach ailments, for wound healing, and as antipyretic and anti-inflammatory agents. In addition, <i>Piper</i> species could be used as natural antioxidants and antimicrobial agents in food preservation. The phytochemicals and essential oils of <i>Piper</i> species have shown strong antioxidant activity, in comparison with synthetic antioxidants, and demonstrated antibacterial and antifungal activities against human pathogens. Moreover, <i>Piper</i> species possess therapeutic and preventive potential against several chronic disorders. Among the functional properties of <i>Piper</i> plants/extracts/active components the antiproliferative, anti-inflammatory, and neuropharmacological activities of the extracts and extract-derived bioactive constituents are thought to be key effects for the protection against chronic conditions, based on preclinical in vitro and in vivo studies, besides clinical studies. Habitats and cultivation of <i>Piper</i> species are also covered in this review. In this current work, available literature of chemical constituents of the essential oils <i>Piper</i> plants, their use in traditional medicine, their applications as a food preservative, their antiparasitic activities and other important biological activities are reviewed. |
| first_indexed | 2024-12-13T14:32:09Z |
| format | Article |
| id | doaj.art-d73ad06085124f2ba6532e50dea77203 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-13T14:32:09Z |
| publishDate | 2019-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-d73ad06085124f2ba6532e50dea772032022-12-21T23:41:49ZengMDPI AGMolecules1420-30492019-04-01247136410.3390/molecules24071364molecules24071364<i>Piper</i> Species: A Comprehensive Review on Their Phytochemistry, Biological Activities and ApplicationsBahare Salehi0Zainul Amiruddin Zakaria1Rabin Gyawali2Salam A. Ibrahim3Jovana Rajkovic4Zabta Khan Shinwari5Tariq Khan6Javad Sharifi-Rad7Adem Ozleyen8Elif Turkdonmez9Marco Valussi10Tugba Boyunegmez Tumer11Lianet Monzote Fidalgo12Miquel Martorell13William N. Setzer14Student Research Committee, School of Medicine, Bam University of Medical Sciences, Bam 44340847, IranDepartment of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, MalaysiaDepartment of Food and Nutritional Sciences, North Carolina A&T State University, Greensboro, NC 27411, USADepartment of Food and Nutritional Sciences, North Carolina A&T State University, Greensboro, NC 27411, USAInstitute of Pharmacology, Clinical Pharmacology and Toxicology, Medical Faculty, University of Belgrade, 11129 Belgrade, SerbiaDepartment of Biotechnology, Quaid-i-Azam University, Islamabad 45320, PakistanDepartment of Biotechnology, Quaid-i-Azam University, Islamabad 45320, PakistanFood Safety Research Center (salt), Semnan University of Medical Sciences, Semnan 35198-99951, IranGraduate Program of Biomolecular Sciences, Institute of Natural and Applied Sciences, Canakkale Onsekiz Mart University, 17020 Canakkale, TurkeyGraduate Program of Biomolecular Sciences, Institute of Natural and Applied Sciences, Canakkale Onsekiz Mart University, 17020 Canakkale, TurkeyEuropean Herbal and Traditional Medicine Practitioners Association (EHTPA), 25 Lincoln Close, Tewkesbury GL20 5TY, UKDepartment of Molecular Biology and Genetics, Faculty of Arts and Science, Canakkale Onsekiz Mart University, 17020 Canakkale, TurkeyParasitology Department, Institute of Tropical Medicine “Pedro Kouri”, Havana 10400, CubaDepartment of Nutrition and Dietetics, Faculty of Pharmacy, University of Concepcion, 4070386 Concepcion, VIII-Bio Bio Region, ChileDepartment of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA<i>Piper</i> species are aromatic plants used as spices in the kitchen, but their secondary metabolites have also shown biological effects on human health. These plants are rich in essential oils, which can be found in their fruits, seeds, leaves, branches, roots and stems. Some <i>Piper</i> species have simple chemical profiles, while others, such as <i>Piper nigrum</i>, <i>Piper betle</i>, and <i>Piper auritum</i>, contain very diverse suites of secondary metabolites. In traditional medicine, <i>Piper</i> species have been used worldwide to treat several diseases such as urological problems, skin, liver and stomach ailments, for wound healing, and as antipyretic and anti-inflammatory agents. In addition, <i>Piper</i> species could be used as natural antioxidants and antimicrobial agents in food preservation. The phytochemicals and essential oils of <i>Piper</i> species have shown strong antioxidant activity, in comparison with synthetic antioxidants, and demonstrated antibacterial and antifungal activities against human pathogens. Moreover, <i>Piper</i> species possess therapeutic and preventive potential against several chronic disorders. Among the functional properties of <i>Piper</i> plants/extracts/active components the antiproliferative, anti-inflammatory, and neuropharmacological activities of the extracts and extract-derived bioactive constituents are thought to be key effects for the protection against chronic conditions, based on preclinical in vitro and in vivo studies, besides clinical studies. Habitats and cultivation of <i>Piper</i> species are also covered in this review. In this current work, available literature of chemical constituents of the essential oils <i>Piper</i> plants, their use in traditional medicine, their applications as a food preservative, their antiparasitic activities and other important biological activities are reviewed.https://www.mdpi.com/1420-3049/24/7/1364pepperessential oilantimicrobialtraditional medicineanticanceranti-inflammatory |
| spellingShingle | Bahare Salehi Zainul Amiruddin Zakaria Rabin Gyawali Salam A. Ibrahim Jovana Rajkovic Zabta Khan Shinwari Tariq Khan Javad Sharifi-Rad Adem Ozleyen Elif Turkdonmez Marco Valussi Tugba Boyunegmez Tumer Lianet Monzote Fidalgo Miquel Martorell William N. Setzer <i>Piper</i> Species: A Comprehensive Review on Their Phytochemistry, Biological Activities and Applications Molecules pepper essential oil antimicrobial traditional medicine anticancer anti-inflammatory |
| title | <i>Piper</i> Species: A Comprehensive Review on Their Phytochemistry, Biological Activities and Applications |
| title_full | <i>Piper</i> Species: A Comprehensive Review on Their Phytochemistry, Biological Activities and Applications |
| title_fullStr | <i>Piper</i> Species: A Comprehensive Review on Their Phytochemistry, Biological Activities and Applications |
| title_full_unstemmed | <i>Piper</i> Species: A Comprehensive Review on Their Phytochemistry, Biological Activities and Applications |
| title_short | <i>Piper</i> Species: A Comprehensive Review on Their Phytochemistry, Biological Activities and Applications |
| title_sort | i piper i species a comprehensive review on their phytochemistry biological activities and applications |
| topic | pepper essential oil antimicrobial traditional medicine anticancer anti-inflammatory |
| url | https://www.mdpi.com/1420-3049/24/7/1364 |
| work_keys_str_mv | AT baharesalehi ipiperispeciesacomprehensivereviewontheirphytochemistrybiologicalactivitiesandapplications AT zainulamiruddinzakaria ipiperispeciesacomprehensivereviewontheirphytochemistrybiologicalactivitiesandapplications AT rabingyawali ipiperispeciesacomprehensivereviewontheirphytochemistrybiologicalactivitiesandapplications AT salamaibrahim ipiperispeciesacomprehensivereviewontheirphytochemistrybiologicalactivitiesandapplications AT jovanarajkovic ipiperispeciesacomprehensivereviewontheirphytochemistrybiologicalactivitiesandapplications AT zabtakhanshinwari ipiperispeciesacomprehensivereviewontheirphytochemistrybiologicalactivitiesandapplications AT tariqkhan ipiperispeciesacomprehensivereviewontheirphytochemistrybiologicalactivitiesandapplications AT javadsharifirad ipiperispeciesacomprehensivereviewontheirphytochemistrybiologicalactivitiesandapplications AT ademozleyen ipiperispeciesacomprehensivereviewontheirphytochemistrybiologicalactivitiesandapplications AT elifturkdonmez ipiperispeciesacomprehensivereviewontheirphytochemistrybiologicalactivitiesandapplications AT marcovalussi ipiperispeciesacomprehensivereviewontheirphytochemistrybiologicalactivitiesandapplications AT tugbaboyunegmeztumer ipiperispeciesacomprehensivereviewontheirphytochemistrybiologicalactivitiesandapplications AT lianetmonzotefidalgo ipiperispeciesacomprehensivereviewontheirphytochemistrybiologicalactivitiesandapplications AT miquelmartorell ipiperispeciesacomprehensivereviewontheirphytochemistrybiologicalactivitiesandapplications AT williamnsetzer ipiperispeciesacomprehensivereviewontheirphytochemistrybiologicalactivitiesandapplications |