HBV Core Protein Enhances Cytokine Production
Hepatitis B virus (HBV) infection, a cause of hepatocellular carcinoma (HCC), remains a serious global health concern. HCC development and human hepatocarcinogenesis are associated with hepatic inflammation caused by host interferons and cytokines. This article focused on the association between th...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2015-09-01
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| Series: | Diseases |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2079-9721/3/3/213 |
| _version_ | 1811202905917620224 |
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| author | Tatsuo Kanda Shuang Wu Reina Sasaki Masato Nakamura Yuki Haga Xia Jiang Shingo Nakamoto Osamu Yokosuka |
| author_facet | Tatsuo Kanda Shuang Wu Reina Sasaki Masato Nakamura Yuki Haga Xia Jiang Shingo Nakamoto Osamu Yokosuka |
| author_sort | Tatsuo Kanda |
| collection | DOAJ |
| description | Hepatitis B virus (HBV) infection, a cause of hepatocellular carcinoma (HCC), remains a serious global health concern. HCC development and human hepatocarcinogenesis are associated with hepatic inflammation caused by host interferons and cytokines. This article focused on the association between the HBV core protein, which is one of the HBV-encoding proteins, and cytokine production. The HBV core protein induced the production of interferons and cytokines in human hepatoma cells and in a mouse model. These factors may be responsible for persistent HBV infection and hepatocarcinogenesis. Inhibitors of programmed death (PD)-1 and HBV core and therapeutic vaccines including HBV core might be useful for the treatment of patients with chronic HBV infection. Inhibitors of HBV core, which is important for hepatic inflammation, could be helpful in preventing the progression of liver diseases in HBV-infected patients. |
| first_indexed | 2024-04-12T02:46:56Z |
| format | Article |
| id | doaj.art-d73c119409fe42baa2005ec6b25b7277 |
| institution | Directory Open Access Journal |
| issn | 2079-9721 |
| language | English |
| last_indexed | 2024-04-12T02:46:56Z |
| publishDate | 2015-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diseases |
| spelling | doaj.art-d73c119409fe42baa2005ec6b25b72772022-12-22T03:51:10ZengMDPI AGDiseases2079-97212015-09-013321322010.3390/diseases3030213diseases3030213HBV Core Protein Enhances Cytokine ProductionTatsuo Kanda0Shuang Wu1Reina Sasaki2Masato Nakamura3Yuki Haga4Xia Jiang5Shingo Nakamoto6Osamu Yokosuka7Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, JapanDepartment of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, JapanDepartment of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, JapanDepartment of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, JapanDepartment of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, JapanDepartment of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, JapanDepartment of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, JapanDepartment of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, JapanHepatitis B virus (HBV) infection, a cause of hepatocellular carcinoma (HCC), remains a serious global health concern. HCC development and human hepatocarcinogenesis are associated with hepatic inflammation caused by host interferons and cytokines. This article focused on the association between the HBV core protein, which is one of the HBV-encoding proteins, and cytokine production. The HBV core protein induced the production of interferons and cytokines in human hepatoma cells and in a mouse model. These factors may be responsible for persistent HBV infection and hepatocarcinogenesis. Inhibitors of programmed death (PD)-1 and HBV core and therapeutic vaccines including HBV core might be useful for the treatment of patients with chronic HBV infection. Inhibitors of HBV core, which is important for hepatic inflammation, could be helpful in preventing the progression of liver diseases in HBV-infected patients.http://www.mdpi.com/2079-9721/3/3/213HBVcorecytokineinterferon |
| spellingShingle | Tatsuo Kanda Shuang Wu Reina Sasaki Masato Nakamura Yuki Haga Xia Jiang Shingo Nakamoto Osamu Yokosuka HBV Core Protein Enhances Cytokine Production Diseases HBV core cytokine interferon |
| title | HBV Core Protein Enhances Cytokine Production |
| title_full | HBV Core Protein Enhances Cytokine Production |
| title_fullStr | HBV Core Protein Enhances Cytokine Production |
| title_full_unstemmed | HBV Core Protein Enhances Cytokine Production |
| title_short | HBV Core Protein Enhances Cytokine Production |
| title_sort | hbv core protein enhances cytokine production |
| topic | HBV core cytokine interferon |
| url | http://www.mdpi.com/2079-9721/3/3/213 |
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