Altered spontaneous brain activity patterns in dysthyroid optic neuropathy: a resting-state fMRI study

This research investigates the characteristics of spontaneous brain activity in dysthyroid optic neuropathy patients using the regional homogeneity technique. Sixteen patients with dysthyroid optic neuropathy and 16 thyroid-associated ophthalmopathy patients without dysthyroid optic neuropathy were...

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Main Authors: Yi-Ping Jiang, Yan-Chang Yang, Li-Ying Tang, Qian-Min Ge, Wen-Qing Shi, Ting Su, Hui-Ye Shu, Yi-Cong Pan, Rong-Bin Liang, Qiu-Yu Li, Yi Shao
Format: Article
Language:English
Published: IMR Press 2021-06-01
Series:Journal of Integrative Neuroscience
Subjects:
Online Access:https://jin.imrpress.com/fileup/1757-448X/PDF/1625014733739-1652602723.pdf
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author Yi-Ping Jiang
Yan-Chang Yang
Li-Ying Tang
Qian-Min Ge
Wen-Qing Shi
Ting Su
Hui-Ye Shu
Yi-Cong Pan
Rong-Bin Liang
Qiu-Yu Li
Yi Shao
author_facet Yi-Ping Jiang
Yan-Chang Yang
Li-Ying Tang
Qian-Min Ge
Wen-Qing Shi
Ting Su
Hui-Ye Shu
Yi-Cong Pan
Rong-Bin Liang
Qiu-Yu Li
Yi Shao
author_sort Yi-Ping Jiang
collection DOAJ
description This research investigates the characteristics of spontaneous brain activity in dysthyroid optic neuropathy patients using the regional homogeneity technique. Sixteen patients with dysthyroid optic neuropathy and 16 thyroid-associated ophthalmopathy patients without dysthyroid optic neuropathy were recruited, matched for weight, height, age, sex, and educational level. All participants underwent resting-state functional nuclear resonance imaging, and the characteristics of spontaneous brain activity were evaluated using the regional homogeneity technique. Each participant in the dysthyroid optic neuropathy group also completed the Hospital Anxiety and Depression scale. Receiver operating characteristic curves were used to compare brain activity between the two groups. Pearson correlation analysis evaluated the relationship between regional homogeneity and clinical manifestations in dysthyroid optic neuropathy patients. In addition, we analyzed the correlation between Hospital Anxiety and Depression scale and regional homogeneity. We found that the regional homogeneity values at the corpus callosum/cingulate gyrus and parietal lobe/middle frontal gyrus significantly decreased in dysthyroid optic neuropathy patients. Regional homogeneity values at the corpus callosum/cingulate gyrus and parietal lobe/middle frontal gyrus were negatively correlated with Hospital Anxiety and Depression scale and disease duration. It was found that the regional homogeneity signal values were significantly lower than in thyroid-associated ophthalmopathy without in dysthyroid optic neuropathy, which may indicate a risk of regional brain dysfunction in dysthyroid optic neuropathy. The results show that regional homogeneity has the potential for early diagnosis and prevent dysthyroid optic neuropathy. In addition, the findings suggest possible mechanisms of dysthyroid optic neuropathy optic nerve injury. They may provide a valuable basis for further research on the pathological mechanisms of dysthyroid optic neuropathy.
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spelling doaj.art-d73d1ea10c9e454595e899a4849f1f732022-12-22T02:25:31ZengIMR PressJournal of Integrative Neuroscience1757-448X2021-06-0120237538310.31083/j.jin20020371625014733739-1652602723Altered spontaneous brain activity patterns in dysthyroid optic neuropathy: a resting-state fMRI studyYi-Ping Jiang0Yan-Chang Yang1Li-Ying Tang2Qian-Min Ge3Wen-Qing Shi4Ting Su5Hui-Ye Shu6Yi-Cong Pan7Rong-Bin Liang8Qiu-Yu Li9Yi Shao10Department of Ophthalmology, The First Affiliated Hospital of Gannan Medical University, 341000 Ganzhou, Jiangxi Province, ChinaDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang University, 330006 Nanchang, Jiangxi Province, ChinaDepartment of Ophthalmology, Eye Institute of Xiamen University, School of Medicine, Xiamen University, Zhongshan Hospital, Xiamen University, 361102 Xiamen, Fujian Province, ChinaDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang University, 330006 Nanchang, Jiangxi Province, ChinaDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang University, 330006 Nanchang, Jiangxi Province, ChinaDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang University, 330006 Nanchang, Jiangxi Province, ChinaDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang University, 330006 Nanchang, Jiangxi Province, ChinaDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang University, 330006 Nanchang, Jiangxi Province, ChinaDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang University, 330006 Nanchang, Jiangxi Province, ChinaDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang University, 330006 Nanchang, Jiangxi Province, ChinaDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang University, 330006 Nanchang, Jiangxi Province, ChinaThis research investigates the characteristics of spontaneous brain activity in dysthyroid optic neuropathy patients using the regional homogeneity technique. Sixteen patients with dysthyroid optic neuropathy and 16 thyroid-associated ophthalmopathy patients without dysthyroid optic neuropathy were recruited, matched for weight, height, age, sex, and educational level. All participants underwent resting-state functional nuclear resonance imaging, and the characteristics of spontaneous brain activity were evaluated using the regional homogeneity technique. Each participant in the dysthyroid optic neuropathy group also completed the Hospital Anxiety and Depression scale. Receiver operating characteristic curves were used to compare brain activity between the two groups. Pearson correlation analysis evaluated the relationship between regional homogeneity and clinical manifestations in dysthyroid optic neuropathy patients. In addition, we analyzed the correlation between Hospital Anxiety and Depression scale and regional homogeneity. We found that the regional homogeneity values at the corpus callosum/cingulate gyrus and parietal lobe/middle frontal gyrus significantly decreased in dysthyroid optic neuropathy patients. Regional homogeneity values at the corpus callosum/cingulate gyrus and parietal lobe/middle frontal gyrus were negatively correlated with Hospital Anxiety and Depression scale and disease duration. It was found that the regional homogeneity signal values were significantly lower than in thyroid-associated ophthalmopathy without in dysthyroid optic neuropathy, which may indicate a risk of regional brain dysfunction in dysthyroid optic neuropathy. The results show that regional homogeneity has the potential for early diagnosis and prevent dysthyroid optic neuropathy. In addition, the findings suggest possible mechanisms of dysthyroid optic neuropathy optic nerve injury. They may provide a valuable basis for further research on the pathological mechanisms of dysthyroid optic neuropathy.https://jin.imrpress.com/fileup/1757-448X/PDF/1625014733739-1652602723.pdfdysthyroid optic neuropathyregional homogeneitythyroid-associated ophthalmopathyresting-state fmrihospital anxiety and depression
spellingShingle Yi-Ping Jiang
Yan-Chang Yang
Li-Ying Tang
Qian-Min Ge
Wen-Qing Shi
Ting Su
Hui-Ye Shu
Yi-Cong Pan
Rong-Bin Liang
Qiu-Yu Li
Yi Shao
Altered spontaneous brain activity patterns in dysthyroid optic neuropathy: a resting-state fMRI study
Journal of Integrative Neuroscience
dysthyroid optic neuropathy
regional homogeneity
thyroid-associated ophthalmopathy
resting-state fmri
hospital anxiety and depression
title Altered spontaneous brain activity patterns in dysthyroid optic neuropathy: a resting-state fMRI study
title_full Altered spontaneous brain activity patterns in dysthyroid optic neuropathy: a resting-state fMRI study
title_fullStr Altered spontaneous brain activity patterns in dysthyroid optic neuropathy: a resting-state fMRI study
title_full_unstemmed Altered spontaneous brain activity patterns in dysthyroid optic neuropathy: a resting-state fMRI study
title_short Altered spontaneous brain activity patterns in dysthyroid optic neuropathy: a resting-state fMRI study
title_sort altered spontaneous brain activity patterns in dysthyroid optic neuropathy a resting state fmri study
topic dysthyroid optic neuropathy
regional homogeneity
thyroid-associated ophthalmopathy
resting-state fmri
hospital anxiety and depression
url https://jin.imrpress.com/fileup/1757-448X/PDF/1625014733739-1652602723.pdf
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