Molecular basis of signalling specificity of insulin and IGF receptors: neglected corners and new advances
Insulin and IGF receptors utilise common PI3K/Akt and Ras/ERK signalling pathways to mediate a broad spectrum of ‘metabolic’ and ‘mitogenic’ responses. Specificity of insulin and IGF action in vivo must in part reflect expression of receptors and responsive pathways in different tissues but it is wi...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2012-02-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fendo.2012.00034/full |