Chitosan–Hyaluronic Acid Nanoparticles for Active Targeting in Cancer Therapy
Cancer is the most common cause of death worldwide; therefore, there is a need to discover novel treatment modalities to combat it. One of the cancer treatments is nanoparticle technology. Currently, nanoparticles have been modified to have desirable pharmacological effects by using chemical ligands...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/14/16/3410 |
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| author | Lisa Efriani Puluhulawa I Made Joni Khaled M. Elamin Ahmed Fouad Abdelwahab Mohammed Muchtaridi Muchtaridi Nasrul Wathoni |
| author_facet | Lisa Efriani Puluhulawa I Made Joni Khaled M. Elamin Ahmed Fouad Abdelwahab Mohammed Muchtaridi Muchtaridi Nasrul Wathoni |
| author_sort | Lisa Efriani Puluhulawa |
| collection | DOAJ |
| description | Cancer is the most common cause of death worldwide; therefore, there is a need to discover novel treatment modalities to combat it. One of the cancer treatments is nanoparticle technology. Currently, nanoparticles have been modified to have desirable pharmacological effects by using chemical ligands that bind with their specific receptors on the surface of malignant cells. Chemical grafting of chitosan nanoparticles with hyaluronic acid as a targeted ligand can become an attractive alternative for active targeting. Hence, these nanoparticles can control drug release with pH- responsive stimuli, and high selectivity of hyaluronic acid to CD44 receptors makes these nanoparticles accumulate more inside cells that overexpress these receptors (cancer cells). In this context, we discuss the benefits and recent findings of developing and utilizing chitosan–hyaluronic acid nanoparticles against distinct forms of cancer malignancy. From here we know that chitosan–hyaluronic acid nanoparticles (CHA-Np) can produce a nanoparticle system with good characteristics, effectiveness, and a good active targeting on various types of cancer cells. Therefore, this system is a good candidate for targeted drug delivery for cancer therapy, anticipating that CHA-Np could be further developed for various cancer therapy applications. |
| first_indexed | 2024-03-09T03:56:00Z |
| format | Article |
| id | doaj.art-d740a6c8a6644e64b478132f50540681 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-09T03:56:00Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-d740a6c8a6644e64b478132f505406812023-12-03T14:20:42ZengMDPI AGPolymers2073-43602022-08-011416341010.3390/polym14163410Chitosan–Hyaluronic Acid Nanoparticles for Active Targeting in Cancer TherapyLisa Efriani Puluhulawa0I Made Joni1Khaled M. Elamin2Ahmed Fouad Abdelwahab Mohammed3Muchtaridi Muchtaridi4Nasrul Wathoni5Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang 45363, IndonesiaDepartment of Physics, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Sumedang 45363, IndonesiaGraduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 862-0973, JapanDepartment of pharmaceutics, Faculty of pharmacy, Minia University, Minia 61519, EgyptDepartement of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang 45363, IndonesiaDepartment of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang 45363, IndonesiaCancer is the most common cause of death worldwide; therefore, there is a need to discover novel treatment modalities to combat it. One of the cancer treatments is nanoparticle technology. Currently, nanoparticles have been modified to have desirable pharmacological effects by using chemical ligands that bind with their specific receptors on the surface of malignant cells. Chemical grafting of chitosan nanoparticles with hyaluronic acid as a targeted ligand can become an attractive alternative for active targeting. Hence, these nanoparticles can control drug release with pH- responsive stimuli, and high selectivity of hyaluronic acid to CD44 receptors makes these nanoparticles accumulate more inside cells that overexpress these receptors (cancer cells). In this context, we discuss the benefits and recent findings of developing and utilizing chitosan–hyaluronic acid nanoparticles against distinct forms of cancer malignancy. From here we know that chitosan–hyaluronic acid nanoparticles (CHA-Np) can produce a nanoparticle system with good characteristics, effectiveness, and a good active targeting on various types of cancer cells. Therefore, this system is a good candidate for targeted drug delivery for cancer therapy, anticipating that CHA-Np could be further developed for various cancer therapy applications.https://www.mdpi.com/2073-4360/14/16/3410cancerchitosanhyaluronic acidnanoparticletargeted delivery |
| spellingShingle | Lisa Efriani Puluhulawa I Made Joni Khaled M. Elamin Ahmed Fouad Abdelwahab Mohammed Muchtaridi Muchtaridi Nasrul Wathoni Chitosan–Hyaluronic Acid Nanoparticles for Active Targeting in Cancer Therapy Polymers cancer chitosan hyaluronic acid nanoparticle targeted delivery |
| title | Chitosan–Hyaluronic Acid Nanoparticles for Active Targeting in Cancer Therapy |
| title_full | Chitosan–Hyaluronic Acid Nanoparticles for Active Targeting in Cancer Therapy |
| title_fullStr | Chitosan–Hyaluronic Acid Nanoparticles for Active Targeting in Cancer Therapy |
| title_full_unstemmed | Chitosan–Hyaluronic Acid Nanoparticles for Active Targeting in Cancer Therapy |
| title_short | Chitosan–Hyaluronic Acid Nanoparticles for Active Targeting in Cancer Therapy |
| title_sort | chitosan hyaluronic acid nanoparticles for active targeting in cancer therapy |
| topic | cancer chitosan hyaluronic acid nanoparticle targeted delivery |
| url | https://www.mdpi.com/2073-4360/14/16/3410 |
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