Multidrug Efflux Systems in Helicobacter cinaedi
Helicobacter cinaedi causes infections, such as bacteremia, diarrhea and cellulitis in mainly immunocompromised patients. This pathogen is often problematic to analyze, and insufficient information is available, because it grows slowly and poorly in subculture under a microaerobic atmosphere. The fi...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2012-11-01
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| Series: | Antibiotics |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2079-6382/1/1/29 |
| _version_ | 1818971717166432256 |
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| author | Yoshiaki Kawamura Junko Tomida Yuji Morita |
| author_facet | Yoshiaki Kawamura Junko Tomida Yuji Morita |
| author_sort | Yoshiaki Kawamura |
| collection | DOAJ |
| description | Helicobacter cinaedi causes infections, such as bacteremia, diarrhea and cellulitis in mainly immunocompromised patients. This pathogen is often problematic to analyze, and insufficient information is available, because it grows slowly and poorly in subculture under a microaerobic atmosphere. The first-choice therapy to eradicate H. cinaedi is antimicrobial chemotherapy; however, its use is linked to the development of resistance. Although we need to understand the antimicrobial resistance mechanisms of H. cinaedi, unfortunately, sufficient genetic tools for H. cinaedi have not yet been developed. In July 2012, the complete sequence of H. cinaedi strain PAGU 611, isolated from a case of human bacteremia, was announced. This strain possesses multidrug efflux systems, intrinsic antimicrobial resistance mechanisms and typical mutations in gyrA and the 23S rRNA gene, which are involved in acquired resistance to fluoroquinolones and macrolides, respectively. Here, we compare the organization and properties of the efflux systems of H. cinaedi with the multidrug efflux systems identified in other bacteria. |
| first_indexed | 2024-12-20T14:56:48Z |
| format | Article |
| id | doaj.art-d740ce99f44349c09b53cf58dd32c732 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-12-20T14:56:48Z |
| publishDate | 2012-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-d740ce99f44349c09b53cf58dd32c7322022-12-21T19:36:48ZengMDPI AGAntibiotics2079-63822012-11-0111294310.3390/antibiotics1010029Multidrug Efflux Systems in Helicobacter cinaediYoshiaki KawamuraJunko TomidaYuji MoritaHelicobacter cinaedi causes infections, such as bacteremia, diarrhea and cellulitis in mainly immunocompromised patients. This pathogen is often problematic to analyze, and insufficient information is available, because it grows slowly and poorly in subculture under a microaerobic atmosphere. The first-choice therapy to eradicate H. cinaedi is antimicrobial chemotherapy; however, its use is linked to the development of resistance. Although we need to understand the antimicrobial resistance mechanisms of H. cinaedi, unfortunately, sufficient genetic tools for H. cinaedi have not yet been developed. In July 2012, the complete sequence of H. cinaedi strain PAGU 611, isolated from a case of human bacteremia, was announced. This strain possesses multidrug efflux systems, intrinsic antimicrobial resistance mechanisms and typical mutations in gyrA and the 23S rRNA gene, which are involved in acquired resistance to fluoroquinolones and macrolides, respectively. Here, we compare the organization and properties of the efflux systems of H. cinaedi with the multidrug efflux systems identified in other bacteria.http://www.mdpi.com/2079-6382/1/1/29Helicobacter cinaedieffluxantimicrobial resistance |
| spellingShingle | Yoshiaki Kawamura Junko Tomida Yuji Morita Multidrug Efflux Systems in Helicobacter cinaedi Antibiotics Helicobacter cinaedi efflux antimicrobial resistance |
| title | Multidrug Efflux Systems in Helicobacter cinaedi |
| title_full | Multidrug Efflux Systems in Helicobacter cinaedi |
| title_fullStr | Multidrug Efflux Systems in Helicobacter cinaedi |
| title_full_unstemmed | Multidrug Efflux Systems in Helicobacter cinaedi |
| title_short | Multidrug Efflux Systems in Helicobacter cinaedi |
| title_sort | multidrug efflux systems in helicobacter cinaedi |
| topic | Helicobacter cinaedi efflux antimicrobial resistance |
| url | http://www.mdpi.com/2079-6382/1/1/29 |
| work_keys_str_mv | AT yoshiakikawamura multidrugeffluxsystemsinhelicobactercinaedi AT junkotomida multidrugeffluxsystemsinhelicobactercinaedi AT yujimorita multidrugeffluxsystemsinhelicobactercinaedi |