Advancements in Hydrogel Application for Ischemic Stroke Therapy
Ischemic stroke is a major cause of death and disability worldwide. There is almost no effective treatment for this disease. Therefore, developing effective treatment for ischemic stroke is urgently needed. Efficient delivery of therapeutic drugs to ischemic sites remained a great challenge for impr...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Gels |
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| Online Access: | https://www.mdpi.com/2310-2861/8/12/777 |
| _version_ | 1827639015393722368 |
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| author | Ying Bai Bing Han Yi Zhang Yuan Zhang Yang Cai Ling Shen Yanpeng Jia |
| author_facet | Ying Bai Bing Han Yi Zhang Yuan Zhang Yang Cai Ling Shen Yanpeng Jia |
| author_sort | Ying Bai |
| collection | DOAJ |
| description | Ischemic stroke is a major cause of death and disability worldwide. There is almost no effective treatment for this disease. Therefore, developing effective treatment for ischemic stroke is urgently needed. Efficient delivery of therapeutic drugs to ischemic sites remained a great challenge for improved treatment of strokes. In recent years, hydrogel-based strategies have been widely investigated for new and improved therapies. They have the advantage of delivering therapeutics in a controlled manner to the poststroke sites, aiming to enhance the intrinsic repair and regeneration. In this review, we discuss the pathophysiology of stroke and the development of injectable hydrogels in the application of both stroke treatment and neural tissue engineering. We also discuss the prospect and the challenges of hydrogels in the treatment of ischemic strokes. |
| first_indexed | 2024-03-09T16:32:45Z |
| format | Article |
| id | doaj.art-d7412b720d5e4c9cbe1d57122b5d7671 |
| institution | Directory Open Access Journal |
| issn | 2310-2861 |
| language | English |
| last_indexed | 2024-03-09T16:32:45Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj.art-d7412b720d5e4c9cbe1d57122b5d76712023-11-24T15:00:51ZengMDPI AGGels2310-28612022-11-0181277710.3390/gels8120777Advancements in Hydrogel Application for Ischemic Stroke TherapyYing Bai0Bing Han1Yi Zhang2Yuan Zhang3Yang Cai4Ling Shen5Yanpeng Jia6Department of Pharmacology, School of Medicine, Southeast University, Nanjing 210009, ChinaDepartment of Pharmacology, School of Medicine, Southeast University, Nanjing 210009, ChinaDepartment of Pharmacology, School of Medicine, Southeast University, Nanjing 210009, ChinaDepartment of Pharmacology, School of Medicine, Southeast University, Nanjing 210009, ChinaDepartment of Pharmacology, School of Medicine, Southeast University, Nanjing 210009, ChinaDepartment of Pharmacology, School of Medicine, Southeast University, Nanjing 210009, ChinaDepartment of Pharmacology, School of Medicine, Southeast University, Nanjing 210009, ChinaIschemic stroke is a major cause of death and disability worldwide. There is almost no effective treatment for this disease. Therefore, developing effective treatment for ischemic stroke is urgently needed. Efficient delivery of therapeutic drugs to ischemic sites remained a great challenge for improved treatment of strokes. In recent years, hydrogel-based strategies have been widely investigated for new and improved therapies. They have the advantage of delivering therapeutics in a controlled manner to the poststroke sites, aiming to enhance the intrinsic repair and regeneration. In this review, we discuss the pathophysiology of stroke and the development of injectable hydrogels in the application of both stroke treatment and neural tissue engineering. We also discuss the prospect and the challenges of hydrogels in the treatment of ischemic strokes.https://www.mdpi.com/2310-2861/8/12/777ischemic strokehydrogelbiomaterialsdrug deliveryregeneration |
| spellingShingle | Ying Bai Bing Han Yi Zhang Yuan Zhang Yang Cai Ling Shen Yanpeng Jia Advancements in Hydrogel Application for Ischemic Stroke Therapy Gels ischemic stroke hydrogel biomaterials drug delivery regeneration |
| title | Advancements in Hydrogel Application for Ischemic Stroke Therapy |
| title_full | Advancements in Hydrogel Application for Ischemic Stroke Therapy |
| title_fullStr | Advancements in Hydrogel Application for Ischemic Stroke Therapy |
| title_full_unstemmed | Advancements in Hydrogel Application for Ischemic Stroke Therapy |
| title_short | Advancements in Hydrogel Application for Ischemic Stroke Therapy |
| title_sort | advancements in hydrogel application for ischemic stroke therapy |
| topic | ischemic stroke hydrogel biomaterials drug delivery regeneration |
| url | https://www.mdpi.com/2310-2861/8/12/777 |
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