Chemoprevention with the metabolism modifying drugs dichloroacetate and metformin in Trp53+/- mice

Chemoprevention with the metabolism modifying drugs dichloroacetate and metformin in Trp53+/- mice

Bibliographic Details
Main Authors:	Blackburn AC, Rooke M, Li Y, Dahlstrom JE, Board PG
Format:	Article
Language:	English
Published:	BMC 2012-04-01
Series:	Hereditary Cancer in Clinical Practice
Online Access:	http://www.hccpjournal.com/content/10/S2/A62

Similar Items

Targeting metabolism with arsenic trioxide and dichloroacetate in breast cancer cells
by: Sun Ramon C, et al.
Published: (2011-11-01)

Chemoprevention of Gastric Cancer: Metformin
by: Young-Il Kim, et al.
Published: (2017-12-01)

Metformin and Dichloroacetate Suppress Proliferation of Liver Cancer Cells by Inhibiting mTOR Complex 1
by: Tae Suk Kim, et al.
Published: (2021-09-01)

Dichloroacetate reverses sepsis-induced hepatic metabolic dysfunction
by: Rabina Mainali, et al.
Published: (2021-02-01)

Haploinsufficiency of Trp53 dramatically extends the lifespan of Sirt6-deficient mice
by: Shrestha Ghosh, et al.
Published: (2018-02-01)

Metformin And Dichloroacetate Combination Exert A Synergistic Effect On Cell Viability Of Oral Squamous Cell Carcinoma
by: Seniz INANC, et al.
Published: (2019-08-01)

Metabolic Response of Pancreatic Carcinoma Cells under Treatment with Dichloroacetate
by: Benedikt Feuerecker, et al.
Published: (2021-05-01)

Synonymous alterations of cancer-associated Trp53 CpG mutational hotspots cause fatal developmental jaw malocclusions but no tumors in knock-in mice.
by: Richard J Epstein, et al.
Published: (2023-01-01)

Synonymous alterations of cancer-associated Trp53 CpG mutational hotspots cause fatal developmental jaw malocclusions but no tumors in knock-in mice
by: Richard J. Epstein, et al.
Published: (2023-01-01)

Crystal structure of diisopropylaminium dichloroacetate
by: Wei Sun, et al.
Published: (2015-05-01)

p53 regulation by TRP2 is not pervasive in melanoma.
by: Roland Houben, et al.
Published: (2014-01-01)

Metformin and sodium dichloroacetate effects on proliferation, apoptosis, and metabolic activity tested alone and in combination in a canine prostate and a bladder cancer cell line.
by: Katharina Klose, et al.
Published: (2021-01-01)

The Protein Tyrosine Phosphatase Rptpζ Suppresses Osteosarcoma Development in Trp53-Heterozygous Mice.
by: Christina Baldauf, et al.
Published: (2015-01-01)

Mutational signatures in tumours induced by high and low energy radiation in Trp53 deficient mice
by: Yun Rose Li, et al.
Published: (2020-01-01)

Short-term carcinogenicity study of N-methyl-N-nitrosourea in FVB-Trp53 heterozygous mice.
by: Na-Won Kim, et al.
Published: (2023-01-01)

Optimization of dichloroacetic acid hydrogenation reactor
by: A. G. Loshchev, et al.
Published: (2008-08-01)

Differential Effects of Trp53 Alterations in Murine Colorectal Cancer
by: Alexander M. Betzler, et al.
Published: (2021-02-01)

Distinct oncogenic phenotypes in hematopoietic specific deletions of Trp53
by: Jayanth Kumar Palanichamy, et al.
Published: (2023-05-01)

Pyruvate Dehydrogenase Kinase Inhibition by Dichloroacetate in Melanoma Cells Unveils Metabolic Vulnerabilities
by: Jiske F. Tiersma, et al.
Published: (2022-03-01)

Targeting Glucose Metabolism of Cancer Cells with Dichloroacetate to Radiosensitize High-Grade Gliomas
by: Kristina M. Cook, et al.
Published: (2021-07-01)

Restricting tumor lactic acid metabolism using dichloroacetate improves T cell functions
by: Hosein Rostamian, et al.
Published: (2022-01-01)

Metabolic status differentiates Trp53inp2 function in pressure-overload induced heart failure
by: Jianfang Liu, et al.
Published: (2023-12-01)

Chemosensitivity to doxorubicin in primary cells derived from tumor of FVB/N-Trp53tm1Hw1 with TALEN-mediated Trp53 mutant gene
by: Woobin Yun, et al.
Published: (2023-10-01)

Mice with Trp53 and Rb1 deficiency in chondrocytes spontaneously develop chondrosarcoma via overactivation of YAP signaling
by: Yang Li, et al.
Published: (2022-06-01)

Igf2 pathway dependency of the Trp53 developmental and tumour phenotypes.
by: Haley, V, et al.
Published: (2012)

Mitaplatin, a Potent Fusion of Cisplatin and the Orphan Drug Dichloroacetate
by: Lippard, Stephen J., et al.
Published: (2011)

Dichloroacetate Radiosensitizes Hypoxic Breast Cancer Cells
by: Sven de Mey, et al.
Published: (2020-12-01)

Neuroprotective Effects and Therapeutic Potential of Dichloroacetate: Targeting Metabolic Disorders in Nervous System Diseases
by: Zhang Y, et al.
Published: (2023-12-01)

Dichloroacetate-induced metabolic reprogramming improves lifespan in a Drosophila model of surviving sepsis.
by: Veli Bakalov, et al.
Published: (2020-01-01)

Commentary on New Formaldehyde Studies in Trp53 Haploinsufficient Mice: Further Support for Nonlinear Risks From Inhaled Formaldehyde
by: Chad M. Thompson
Published: (2018-05-01)

RINT1 Loss Impairs Retinogenesis Through TRP53-Mediated Apoptosis
by: Anielle L. Gomes, et al.
Published: (2020-07-01)

Role of JNK in a Trp53-dependent mouse model of breast cancer.
by: Cristina Cellurale, et al.
Published: (2010-08-01)

Somatic Trp53 mutations differentially drive breast cancer and evolution of metastases
by: Yun Zhang, et al.
Published: (2018-09-01)

Brca2 and Trp53 deficiency cooperate in the progression of mouse prostate tumourigenesis.
by: Jeffrey C Francis, et al.
Published: (2010-06-01)

Dichloroacetate as a metabolic modulator of heart mitochondrial proteome under conditions of reduced oxygen utilization
by: Natalia Andelova, et al.
Published: (2022-09-01)

Dichloroacetate Stabilizes Mitochondrial Fusion Dynamics in Models of Neurodegeneration
by: Darren O’Hara, et al.
Published: (2019-09-01)

Modelling aggressive prostate cancers of young men in immune-competent mice, driven by isogenic Trp53 alterations and Pten loss
by: Javier Octavio Mejía-Hernández, et al.
Published: (2022-09-01)

Global Deletion of Trp53 Reverts Ovarian Tumor Phenotype of the Germ Cell–Deficient White Spotting Variant (Wv) Mice
by: Kathy Qi Cai, et al.
Published: (2015-01-01)

Role of TRP Channels in Metabolism-Related Diseases
by: Fengming Wu, et al.
Published: (2024-01-01)

Functional and dynamic state of inner mitochondrial membrane of sarcoma 37 in mice under administration of sodium dichloroacetate
by: S. V. Khyzhnyak, et al.
Published: (2014-12-01)